Extracellular thiol isomerase ERp5 regulates integrin αIIbβ3 activation by inhibition of fibrinogen binding

Extracellular thiol isomerase ERp5 regulates integrin αIIbβ3 activation by inhibition of fibrinogen binding

Recent studies have shown that anti-ERp5 antibodies inhibit platelet activation and thrombus formation; Moreover, ERp5-deficient platelets exhibit enhanced platelet reactivity via regulation of endoplasmic reticulum (ER) stress. In this study, we used a new ERp5-knockout mouse model as well as recom...

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Bibliographic Details
Main Authors: Kaifei Sun, Yaqiong Zhang, Aizhen Yang, Yuxin Zhang, Zhenzhen Zhao, Xiaofeng Yan, Yi Lu, Yue Han, Depei Wu, Freda Passam, Jingyu Zhang, Yi Wu
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Platelets
Subjects:
ERp5
integrin αIIbβ3
platelets
redox regulation
thrombosis
Online Access:https://www.tandfonline.com/doi/10.1080/09537104.2025.2455743
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