Intratumor HIF-1α modulates production of a cachectic ligand to cause host wasting

Intratumor HIF-1α modulates production of a cachectic ligand to cause host wasting

Tumor-host interactions play critical roles in cancer-associated cachexia. Previous studies have identified several cachectic proteins secreted by tumors that impair metabolic homeostasis in multiple organs, leading to host wasting. The molecular mechanisms by which malignant tumors regulate the pro...

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Main Authors: Gen Xiao, Yingge Li, Yanhui Hu, Kai Tan, Mengyang Wang, Kerui Zhu, Mingkui San, Qian Cheng, Dilinigeer Tayier, Tingting Hu, Peixuan Dang, Jiaying Li, Chen Cheng, Norbert Perrimon, Zhiyong Yang, Wei Song
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Cell Insight
Online Access:http://www.sciencedirect.com/science/article/pii/S2772892725000215
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