Age-associated differences in mucosal and systemic host responses to SARS-CoV-2 infection

Age-associated differences in mucosal and systemic host responses to SARS-CoV-2 infection

Abstract Age is among the strongest risk factors for severe outcomes from SARS-CoV-2 infection. Here we describe upper respiratory tract (URT) and peripheral blood transcriptomes of 202 participants (age range of 1 week to 83 years), including 137 non-hospitalized individuals with mild SARS-CoV-2 in...

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Main Authors: Jillian H. Hurst, Aditya A. Mohan, Trisha Dalapati, Ian A. George, Jhoanna N. Aquino, Debra J. Lugo, Trevor S. Pfeiffer, Javier Rodriguez, Alexandre T. Rotta, Nicholas A. Turner, Thomas W. Burke, Micah T. McClain, Ricardo Henao, C. Todd DeMarco, Raul Louzao, Thomas N. Denny, Kyle M. Walsh, Zhaohui Xu, Asuncion Mejias, Octavio Ramilo, Christopher W. Woods, Matthew S. Kelly
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-57655-3
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