Nickel-Catalyzed Three-Component 1,2-Carboacylation of Alkenes
Ketones, prevalent in many biologically significant molecules, require the development of novel methods to synthesize these structures, which is a critical endeavor in organic synthesis. Transition metal catalysis has proven to be an effective method for synthesizing ketones. However, the scope of t...
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| Language: | English |
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MDPI AG
2024-09-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/29/18/4295 |
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| author | Shengzhou Jin Lanfen Wang Yinggang Jia Wenbo Ma Dingyi Wang |
| author_facet | Shengzhou Jin Lanfen Wang Yinggang Jia Wenbo Ma Dingyi Wang |
| author_sort | Shengzhou Jin |
| collection | DOAJ |
| description | Ketones, prevalent in many biologically significant molecules, require the development of novel methods to synthesize these structures, which is a critical endeavor in organic synthesis. Transition metal catalysis has proven to be an effective method for synthesizing ketones. However, the scope of these substrates remains relatively limited, particularly due to their incompatibility with sensitive functional groups. Herein, we report a Ni-catalyzed three-component 1,2-carboacylation of alkenes, which activates secondary/tertiary alkyl bromides. This method offers significant advantages: simplicity of operation, ready availability of substrates, and broad substrate applicability. A series of experimental studies have helped clarify the key mechanistic pathways involved in this cascade reaction. |
| format | Article |
| id | doaj-art-2ccbdedee15e4a808209e5d42e7a1562 |
| institution | OA Journals |
| issn | 1420-3049 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj-art-2ccbdedee15e4a808209e5d42e7a15622025-08-20T01:55:42ZengMDPI AGMolecules1420-30492024-09-012918429510.3390/molecules29184295Nickel-Catalyzed Three-Component 1,2-Carboacylation of AlkenesShengzhou Jin0Lanfen Wang1Yinggang Jia2Wenbo Ma3Dingyi Wang4Hubei Key Laboratory of Pollutant Analysis & Reuse Technology, College of Chemistry and Chemical Engineering, Hubei Normal University, Huangshi 435002, ChinaCollege of Sciences, Northeastern University, Shenyang 110004, ChinaCollege of Sciences, Northeastern University, Shenyang 110004, ChinaAntibiotics Research and Re-Evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, National Base for International Science and Technology Cooperation of Chengdu University, Chengdu University, Chengdu 610106, ChinaCollege of Sciences, Northeastern University, Shenyang 110004, ChinaKetones, prevalent in many biologically significant molecules, require the development of novel methods to synthesize these structures, which is a critical endeavor in organic synthesis. Transition metal catalysis has proven to be an effective method for synthesizing ketones. However, the scope of these substrates remains relatively limited, particularly due to their incompatibility with sensitive functional groups. Herein, we report a Ni-catalyzed three-component 1,2-carboacylation of alkenes, which activates secondary/tertiary alkyl bromides. This method offers significant advantages: simplicity of operation, ready availability of substrates, and broad substrate applicability. A series of experimental studies have helped clarify the key mechanistic pathways involved in this cascade reaction.https://www.mdpi.com/1420-3049/29/18/4295nickel-catalyzedcarboacylationalkenesacyl chloridesalkyl bromides |
| spellingShingle | Shengzhou Jin Lanfen Wang Yinggang Jia Wenbo Ma Dingyi Wang Nickel-Catalyzed Three-Component 1,2-Carboacylation of Alkenes Molecules nickel-catalyzed carboacylation alkenes acyl chlorides alkyl bromides |
| title | Nickel-Catalyzed Three-Component 1,2-Carboacylation of Alkenes |
| title_full | Nickel-Catalyzed Three-Component 1,2-Carboacylation of Alkenes |
| title_fullStr | Nickel-Catalyzed Three-Component 1,2-Carboacylation of Alkenes |
| title_full_unstemmed | Nickel-Catalyzed Three-Component 1,2-Carboacylation of Alkenes |
| title_short | Nickel-Catalyzed Three-Component 1,2-Carboacylation of Alkenes |
| title_sort | nickel catalyzed three component 1 2 carboacylation of alkenes |
| topic | nickel-catalyzed carboacylation alkenes acyl chlorides alkyl bromides |
| url | https://www.mdpi.com/1420-3049/29/18/4295 |
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