Enhancing Skin Wound Healing in Diabetic Mice Using SIKVAV-Modified Chitosan Hydrogels
Diabetic foot ulcers (DFUs), a prevalent chronic disease caused by various factors, significantly impact patients’ quality of life due to prolonged healing times and increased infection risks. Current treatment modalities, including pharmacological, physical, and surgical interventions, often yield...
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MDPI AG
2024-11-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/29/22/5374 |
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| author | Xionglin Chen Xiaoming Cao Jie Zhang Chen Jiang Yitian Yu Hui Chen |
| author_facet | Xionglin Chen Xiaoming Cao Jie Zhang Chen Jiang Yitian Yu Hui Chen |
| author_sort | Xionglin Chen |
| collection | DOAJ |
| description | Diabetic foot ulcers (DFUs), a prevalent chronic disease caused by various factors, significantly impact patients’ quality of life due to prolonged healing times and increased infection risks. Current treatment modalities, including pharmacological, physical, and surgical interventions, often yield limited efficacy and adverse effects, highlighting the urgent need for novel therapeutic strategies. The objective of this research is to create SIKVAV-modified chitosan hydrogels with the intention of improving the process of skin wound healing in diabetic mice. We synthesized the hydrogels and established a diabetic mice model with skin wounding to evaluate its healing effects and underlying mechanisms. The results of our study indicate that the SIKVAV-modified chitosan hydrogels markedly enhance the wound healing process in diabetic mice. This effect may be attributed to several mechanisms, including differentiation of fibroblasts, proliferation of keratinocytes, the promotion of angiogenesis, stimulation of collagen synthesis, upregulation of growth factor expression, and possible involvement of the TGF-β1/Smad3 signaling pathway. This research not only provides a new biomaterial for the treatment of diabetic wounds but also elucidates the related molecular mechanisms involved in wound healing of DFUs, offering valuable insights for future clinical applications. |
| format | Article |
| id | doaj-art-2cc7ab7bc37e4ef1adc5c762eea26fed |
| institution | OA Journals |
| issn | 1420-3049 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj-art-2cc7ab7bc37e4ef1adc5c762eea26fed2025-08-20T02:05:06ZengMDPI AGMolecules1420-30492024-11-012922537410.3390/molecules29225374Enhancing Skin Wound Healing in Diabetic Mice Using SIKVAV-Modified Chitosan HydrogelsXionglin Chen0Xiaoming Cao1Jie Zhang2Chen Jiang3Yitian Yu4Hui Chen5Jiangxi Provincial Key Laboratory of Cell Precision Therapy, Department of Histology, Embryology and Medical Genetics, School of Basic Medical Sciences, Jiujiang University, Jiujiang 332000, ChinaDepartment of Anatomy, School of Basic Medical Sciences, Jiujiang University, Jiujiang 332000, ChinaJiangxi Provincial Key Laboratory of Cell Precision Therapy, Department of Histology, Embryology and Medical Genetics, School of Basic Medical Sciences, Jiujiang University, Jiujiang 332000, ChinaDepartment of Oral Medicine, Grade 2021, School of Basic Medical Sciences, Jiujiang University, Jiujiang 332000, ChinaDepartment of Clinical Medicine, Grade 2023, School of Basic Medicine, Jiujiang University, Jiujiang 332000, ChinaDepartment of Anatomy, School of Basic Medical Sciences, Jiujiang University, Jiujiang 332000, ChinaDiabetic foot ulcers (DFUs), a prevalent chronic disease caused by various factors, significantly impact patients’ quality of life due to prolonged healing times and increased infection risks. Current treatment modalities, including pharmacological, physical, and surgical interventions, often yield limited efficacy and adverse effects, highlighting the urgent need for novel therapeutic strategies. The objective of this research is to create SIKVAV-modified chitosan hydrogels with the intention of improving the process of skin wound healing in diabetic mice. We synthesized the hydrogels and established a diabetic mice model with skin wounding to evaluate its healing effects and underlying mechanisms. The results of our study indicate that the SIKVAV-modified chitosan hydrogels markedly enhance the wound healing process in diabetic mice. This effect may be attributed to several mechanisms, including differentiation of fibroblasts, proliferation of keratinocytes, the promotion of angiogenesis, stimulation of collagen synthesis, upregulation of growth factor expression, and possible involvement of the TGF-β1/Smad3 signaling pathway. This research not only provides a new biomaterial for the treatment of diabetic wounds but also elucidates the related molecular mechanisms involved in wound healing of DFUs, offering valuable insights for future clinical applications.https://www.mdpi.com/1420-3049/29/22/5374DFUsSIKVAVchitosan hydrogelsskin wound healingTGF-β1Smad3 |
| spellingShingle | Xionglin Chen Xiaoming Cao Jie Zhang Chen Jiang Yitian Yu Hui Chen Enhancing Skin Wound Healing in Diabetic Mice Using SIKVAV-Modified Chitosan Hydrogels Molecules DFUs SIKVAV chitosan hydrogels skin wound healing TGF-β1 Smad3 |
| title | Enhancing Skin Wound Healing in Diabetic Mice Using SIKVAV-Modified Chitosan Hydrogels |
| title_full | Enhancing Skin Wound Healing in Diabetic Mice Using SIKVAV-Modified Chitosan Hydrogels |
| title_fullStr | Enhancing Skin Wound Healing in Diabetic Mice Using SIKVAV-Modified Chitosan Hydrogels |
| title_full_unstemmed | Enhancing Skin Wound Healing in Diabetic Mice Using SIKVAV-Modified Chitosan Hydrogels |
| title_short | Enhancing Skin Wound Healing in Diabetic Mice Using SIKVAV-Modified Chitosan Hydrogels |
| title_sort | enhancing skin wound healing in diabetic mice using sikvav modified chitosan hydrogels |
| topic | DFUs SIKVAV chitosan hydrogels skin wound healing TGF-β1 Smad3 |
| url | https://www.mdpi.com/1420-3049/29/22/5374 |
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