Novel CCL3-HMGB1 signaling axis regulating osteocyte RANKL expression in multiple myeloma

Novel CCL3-HMGB1 signaling axis regulating osteocyte RANKL expression in multiple myeloma

Multiple myeloma (MM) is a clonal plasma cell proliferative malignancy characterized by a debilitating bone disease. Osteolytic destruction, a hallmark of MM, is driven by increased osteoclast number and exacerbated bone resorption, primarily fueled by the excessive production of RANKL, the master...

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Main Authors: Aric Anloague, Hayley M. Sabol, Japneet Kaur, Sharmin Khan, Cody Ashby, Carolina Schinke, C. Lowry Barnes, Farah Alturkmani, Elena Ambrogini, Michael Tveden Gundesen, Thomas Lund, Anne Kristine Amstrup, Thomas Levin Andersen, Marta Diaz-delCastillo, G. David Roodman, Teresita Bellido, Jesus Delgado-Calle
Format: Article
Language:English
Published: Ferrata Storti Foundation 2024-11-01
Series:Haematologica
Online Access:https://haematologica.org/article/view/11852
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