Investigation of the Potential Roles of Thyroid Gland Hormones in the Pathogenesis of Thyroid Disorders
This study was designed to evaluate the roles of total Thyroxine T4, total T3, free Thyroxine FT4, free triiodothyronine FT3, and thyroid stimulating hormone TSH indicators in the pathogenesis of patients with thyroid diseases. Seventy patients with thyroid diseases and thirty healthy individuals (a...
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University of Kirkuk
2024-12-01
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| Series: | Kirkuk Journal of Science |
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| Online Access: | https://kujss.uokirkuk.edu.iq/article_185825_84c595637605d4ea187fc0ea321e3e15.pdf |
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| author | Enas Sobeih Mohammed .Alwan Arwa Hussein Ali Abd Almuna'am |
| author_facet | Enas Sobeih Mohammed .Alwan Arwa Hussein Ali Abd Almuna'am |
| author_sort | Enas Sobeih |
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| description | This study was designed to evaluate the roles of total Thyroxine T4, total T3, free Thyroxine FT4, free triiodothyronine FT3, and thyroid stimulating hormone TSH indicators in the pathogenesis of patients with thyroid diseases. Seventy patients with thyroid diseases and thirty healthy individuals (as a control group) were enrolled in this study from April to July 2024. An HSCL-5000MICRO Homogenous Chemiluminescence Immunoassay Analyzer was used to measure the markers. Most patients were females (82.9%) with age groups; 31-40 (32.9%) and 41-50 (40.0%) years Significantly increased (p<0.05) levels of total T4 in patients than controls, while levels of FT4 were significantly (p<0.05) decreased in patients than controls. In contrast, our research reveals no significant difference (p>0.05) between levels of T3, FT3, and TSH indicators and study groups. ROC curve results showed the FT4 scored the highest sensitivity and specificity (77% and 72%), followed by T4 (68% and 68%) and then TSH (57% and 60%) at cut off values (13.42, 88.28 and 2.67) respectively in screening patients with thyroid diseases with significant different (p<0.05). Our investigation mentions no significant differences (p>0.05) between levels of T4, T3, T4, FT3 and TSH in males versus females and within age groups of patients. It was also noted that there was no significant correlation among thyroid hormones. In conclusion, this study proved that FT4 was more critical for detecting thyroid disease due to its high sensitivity and specificity |
| format | Article |
| id | doaj-art-2cc54f789e6e42f680e1560219db7f0b |
| institution | Kabale University |
| issn | 3005-4788 3005-4796 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | University of Kirkuk |
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| series | Kirkuk Journal of Science |
| spelling | doaj-art-2cc54f789e6e42f680e1560219db7f0b2025-01-10T16:36:33ZengUniversity of KirkukKirkuk Journal of Science3005-47883005-47962024-12-01194293610.32894/kujss.2024.153274.1179185825Investigation of the Potential Roles of Thyroid Gland Hormones in the Pathogenesis of Thyroid DisordersEnas Sobeih0Mohammed .Alwan1Arwa Hussein2Ali Abd Almuna'am3College of Dentistry, Al- Iraqia University, Baghdad, Iraq.Iraqi Ministry of Education, Directorate General of Education DiyalaDepartment of Biology, College of Education for Pure Science ,University Diyala,IraqMOT/ medical city / Baghdad teaching hospitalThis study was designed to evaluate the roles of total Thyroxine T4, total T3, free Thyroxine FT4, free triiodothyronine FT3, and thyroid stimulating hormone TSH indicators in the pathogenesis of patients with thyroid diseases. Seventy patients with thyroid diseases and thirty healthy individuals (as a control group) were enrolled in this study from April to July 2024. An HSCL-5000MICRO Homogenous Chemiluminescence Immunoassay Analyzer was used to measure the markers. Most patients were females (82.9%) with age groups; 31-40 (32.9%) and 41-50 (40.0%) years Significantly increased (p<0.05) levels of total T4 in patients than controls, while levels of FT4 were significantly (p<0.05) decreased in patients than controls. In contrast, our research reveals no significant difference (p>0.05) between levels of T3, FT3, and TSH indicators and study groups. ROC curve results showed the FT4 scored the highest sensitivity and specificity (77% and 72%), followed by T4 (68% and 68%) and then TSH (57% and 60%) at cut off values (13.42, 88.28 and 2.67) respectively in screening patients with thyroid diseases with significant different (p<0.05). Our investigation mentions no significant differences (p>0.05) between levels of T4, T3, T4, FT3 and TSH in males versus females and within age groups of patients. It was also noted that there was no significant correlation among thyroid hormones. In conclusion, this study proved that FT4 was more critical for detecting thyroid disease due to its high sensitivity and specificityhttps://kujss.uokirkuk.edu.iq/article_185825_84c595637605d4ea187fc0ea321e3e15.pdfthyroid diseasest3t4and tsh hormones |
| spellingShingle | Enas Sobeih Mohammed .Alwan Arwa Hussein Ali Abd Almuna'am Investigation of the Potential Roles of Thyroid Gland Hormones in the Pathogenesis of Thyroid Disorders Kirkuk Journal of Science thyroid diseases t3 t4 and tsh hormones |
| title | Investigation of the Potential Roles of Thyroid Gland Hormones in the Pathogenesis of Thyroid Disorders |
| title_full | Investigation of the Potential Roles of Thyroid Gland Hormones in the Pathogenesis of Thyroid Disorders |
| title_fullStr | Investigation of the Potential Roles of Thyroid Gland Hormones in the Pathogenesis of Thyroid Disorders |
| title_full_unstemmed | Investigation of the Potential Roles of Thyroid Gland Hormones in the Pathogenesis of Thyroid Disorders |
| title_short | Investigation of the Potential Roles of Thyroid Gland Hormones in the Pathogenesis of Thyroid Disorders |
| title_sort | investigation of the potential roles of thyroid gland hormones in the pathogenesis of thyroid disorders |
| topic | thyroid diseases t3 t4 and tsh hormones |
| url | https://kujss.uokirkuk.edu.iq/article_185825_84c595637605d4ea187fc0ea321e3e15.pdf |
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