Cerebrovascular-mediated dynamic alterations in neurovascular coupling: a key pathological mechanism of depression
Abstract Neurovascular coupling (NVC) is a vital regulatory mechanism that synchronizes neural activity with vascular responses to support brain function. Although the precise mechanisms of NVC remain incompletely elucidated, its dysfunction is increasingly implicated in the pathogenesis of various...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-07-01
|
| Series: | Cell & Bioscience |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13578-025-01444-4 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849331952999464960 |
|---|---|
| author | Xiaoyun Yang Jiaxin Wang Jiahao Zhang Mengjie Zhang Anran Hao Feng Guo Xueying Huang Jinlan Yan Yuanjia Zheng Yucen Xia Taiyi Wang Meng Zhang Ning Weng Yongjun Chen Lin Yao |
| author_facet | Xiaoyun Yang Jiaxin Wang Jiahao Zhang Mengjie Zhang Anran Hao Feng Guo Xueying Huang Jinlan Yan Yuanjia Zheng Yucen Xia Taiyi Wang Meng Zhang Ning Weng Yongjun Chen Lin Yao |
| author_sort | Xiaoyun Yang |
| collection | DOAJ |
| description | Abstract Neurovascular coupling (NVC) is a vital regulatory mechanism that synchronizes neural activity with vascular responses to support brain function. Although the precise mechanisms of NVC remain incompletely elucidated, its dysfunction is increasingly implicated in the pathogenesis of various neurological disorders. This review synthesizes recent advancements in understanding the vascular cascade, emphasizing key dynamic regulators of NVC, including mechanical forces and diffusible signals mediated by blood flow. We explore the intricate bidirectional interactions between the vasculature and neurons, highlighting their interdependent roles in neurovascular regulation. Using major depressive disorder (MDD) as a case study, we further discuss emerging evidence linking vascular dysfunction and impaired NVC to MDD pathophysiology. These insights position NVC as a promising therapeutic target for emotional disorders, underscoring the pivotal roles of hemodynamic signaling in neurovascular regulation. |
| format | Article |
| id | doaj-art-2cc441eb78c74a5fba9551540a1a8d3a |
| institution | Kabale University |
| issn | 2045-3701 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell & Bioscience |
| spelling | doaj-art-2cc441eb78c74a5fba9551540a1a8d3a2025-08-20T03:46:21ZengBMCCell & Bioscience2045-37012025-07-0115111310.1186/s13578-025-01444-4Cerebrovascular-mediated dynamic alterations in neurovascular coupling: a key pathological mechanism of depressionXiaoyun Yang0Jiaxin Wang1Jiahao Zhang2Mengjie Zhang3Anran Hao4Feng Guo5Xueying Huang6Jinlan Yan7Yuanjia Zheng8Yucen Xia9Taiyi Wang10Meng Zhang11Ning Weng12Yongjun Chen13Lin Yao14Institute of Acupuncture and Moxibustion, Shandong University of Traditional Chinese MedicineInstitute of Acupuncture and Moxibustion, Shandong University of Traditional Chinese MedicineInstitute of Acupuncture and Moxibustion, Shandong University of Traditional Chinese MedicineInstitute of Acupuncture and Moxibustion, Shandong University of Traditional Chinese MedicineInstitute of Acupuncture and Moxibustion, Shandong University of Traditional Chinese MedicineInstitute of Acupuncture and Moxibustion, Shandong University of Traditional Chinese MedicineInstitute of Acupuncture and Moxibustion, Shandong University of Traditional Chinese MedicineInstitute of Acupuncture and Moxibustion, Shandong University of Traditional Chinese MedicineInstitute of Acupuncture and Moxibustion, Shandong University of Traditional Chinese MedicineInstitute of Acupuncture and Moxibustion, Shandong University of Traditional Chinese MedicineInstitute of Acupuncture and Moxibustion, Shandong University of Traditional Chinese MedicineInstitute of Acupuncture and Moxibustion, Shandong University of Traditional Chinese MedicineDepartment of Traditional Chinese Medicine, Shandong Mental Health Center, Shandong UniversityInstitute of Acupuncture and Moxibustion, Shandong University of Traditional Chinese MedicineInstitute of Acupuncture and Moxibustion, Shandong University of Traditional Chinese MedicineAbstract Neurovascular coupling (NVC) is a vital regulatory mechanism that synchronizes neural activity with vascular responses to support brain function. Although the precise mechanisms of NVC remain incompletely elucidated, its dysfunction is increasingly implicated in the pathogenesis of various neurological disorders. This review synthesizes recent advancements in understanding the vascular cascade, emphasizing key dynamic regulators of NVC, including mechanical forces and diffusible signals mediated by blood flow. We explore the intricate bidirectional interactions between the vasculature and neurons, highlighting their interdependent roles in neurovascular regulation. Using major depressive disorder (MDD) as a case study, we further discuss emerging evidence linking vascular dysfunction and impaired NVC to MDD pathophysiology. These insights position NVC as a promising therapeutic target for emotional disorders, underscoring the pivotal roles of hemodynamic signaling in neurovascular regulation.https://doi.org/10.1186/s13578-025-01444-4Neurovascular couplingMajor depressive disorderCerebral blood flowDynamic regulation |
| spellingShingle | Xiaoyun Yang Jiaxin Wang Jiahao Zhang Mengjie Zhang Anran Hao Feng Guo Xueying Huang Jinlan Yan Yuanjia Zheng Yucen Xia Taiyi Wang Meng Zhang Ning Weng Yongjun Chen Lin Yao Cerebrovascular-mediated dynamic alterations in neurovascular coupling: a key pathological mechanism of depression Cell & Bioscience Neurovascular coupling Major depressive disorder Cerebral blood flow Dynamic regulation |
| title | Cerebrovascular-mediated dynamic alterations in neurovascular coupling: a key pathological mechanism of depression |
| title_full | Cerebrovascular-mediated dynamic alterations in neurovascular coupling: a key pathological mechanism of depression |
| title_fullStr | Cerebrovascular-mediated dynamic alterations in neurovascular coupling: a key pathological mechanism of depression |
| title_full_unstemmed | Cerebrovascular-mediated dynamic alterations in neurovascular coupling: a key pathological mechanism of depression |
| title_short | Cerebrovascular-mediated dynamic alterations in neurovascular coupling: a key pathological mechanism of depression |
| title_sort | cerebrovascular mediated dynamic alterations in neurovascular coupling a key pathological mechanism of depression |
| topic | Neurovascular coupling Major depressive disorder Cerebral blood flow Dynamic regulation |
| url | https://doi.org/10.1186/s13578-025-01444-4 |
| work_keys_str_mv | AT xiaoyunyang cerebrovascularmediateddynamicalterationsinneurovascularcouplingakeypathologicalmechanismofdepression AT jiaxinwang cerebrovascularmediateddynamicalterationsinneurovascularcouplingakeypathologicalmechanismofdepression AT jiahaozhang cerebrovascularmediateddynamicalterationsinneurovascularcouplingakeypathologicalmechanismofdepression AT mengjiezhang cerebrovascularmediateddynamicalterationsinneurovascularcouplingakeypathologicalmechanismofdepression AT anranhao cerebrovascularmediateddynamicalterationsinneurovascularcouplingakeypathologicalmechanismofdepression AT fengguo cerebrovascularmediateddynamicalterationsinneurovascularcouplingakeypathologicalmechanismofdepression AT xueyinghuang cerebrovascularmediateddynamicalterationsinneurovascularcouplingakeypathologicalmechanismofdepression AT jinlanyan cerebrovascularmediateddynamicalterationsinneurovascularcouplingakeypathologicalmechanismofdepression AT yuanjiazheng cerebrovascularmediateddynamicalterationsinneurovascularcouplingakeypathologicalmechanismofdepression AT yucenxia cerebrovascularmediateddynamicalterationsinneurovascularcouplingakeypathologicalmechanismofdepression AT taiyiwang cerebrovascularmediateddynamicalterationsinneurovascularcouplingakeypathologicalmechanismofdepression AT mengzhang cerebrovascularmediateddynamicalterationsinneurovascularcouplingakeypathologicalmechanismofdepression AT ningweng cerebrovascularmediateddynamicalterationsinneurovascularcouplingakeypathologicalmechanismofdepression AT yongjunchen cerebrovascularmediateddynamicalterationsinneurovascularcouplingakeypathologicalmechanismofdepression AT linyao cerebrovascularmediateddynamicalterationsinneurovascularcouplingakeypathologicalmechanismofdepression |