ATAD5-BAZ1B interaction modulates PCNA ubiquitination during DNA repair

ATAD5-BAZ1B interaction modulates PCNA ubiquitination during DNA repair

Abstract Mono-ubiquitinated PCNA (mono-Ub-PCNA) is generated when replication forks encounter obstacles, enabling the bypass of DNA lesions. After resolving stalled forks, Ub-PCNA must be de-ubiquitinated to resume high-fidelity DNA synthesis. ATAD5, in cooperation with the UAF1-USP1 complex, is res...

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Bibliographic Details
Main Authors: Yeongjae Kim, Na Young Ha, Mi-Sun Kang, Eunjin Ryu, Geunil Yi, Juyeong Yoo, Nalae Kang, Byung-Gyu Kim, Kyungjae Myung, Sukhyun Kang
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-55005-3
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