Patterns of genomic instability in > 2000 patients with ovarian cancer across six clinical trials evaluating olaparib

Patterns of genomic instability in > 2000 patients with ovarian cancer across six clinical trials evaluating olaparib

Abstract Background The introduction of poly(ADP-ribose) polymerase (PARP) inhibitors represented a paradigm shift in the treatment of ovarian cancer. Genomic data from patients with high-grade ovarian cancer in six phase II/III trials involving the PARP inhibitor olaparib were analyzed to better un...

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Main Authors: Alan Barnicle, Isabelle Ray-Coquard, Etienne Rouleau, Karen Cadoo, Fiona Simpkins, Carol Aghajanian, Alexandra Leary, Andrés Poveda, Stephanie Lheureux, Eric Pujade-Lauraine, Benoit You, Jonathan Ledermann, Ursula Matulonis, Charlie Gourley, Kirsten M. Timms, Zhongwu Lai, Darren R. Hodgson, Cathy E. Elks, Simon Dearden, Coumaran Egile, Pierre Lao-Sirieix, Elizabeth A. Harrington, Jessica S. Brown
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Genome Medicine
Subjects:
Ovarian cancer
Genomic instability
Translational research
Olaparib
Online Access:https://doi.org/10.1186/s13073-024-01413-5
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