Integrating genetics and transcriptomics to characterize shared mechanisms in digestive diseases and psychiatric disorders

Integrating genetics and transcriptomics to characterize shared mechanisms in digestive diseases and psychiatric disorders

Abstract Digestive and psychiatric disorders tend to co-occur, yet mechanisms remain unclear. Leveraging genetic and transcriptomic data integration, we conduct multi-trait analysis of GWAS (MTAG) and weighted gene co-expression network analysis (WGCNA) to explore shared mechanism between psychiatri...

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Main Authors: Huanxin Ding, Yue Jiang, Qing Sun, Yingchao Song, Shuohui Dong, Qian Xu, Linzehao Li, Chuxuan Liu, Bingjun Li, Hengxuan Jiang, Bichen Peng, Shi Peng, Chumeng Zhang, Jiankang Zhu, Mingwei Zhong, Guangyong Zhang, Xiao Chang
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-07481-6
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