Nationwide Genomic Data Analysis of Japanese Prostate Cancer Patients From C‐CAT Database
ABSTRACT Purpose Prostate cancer is a leading malignancy among men, and genomic alterations are known to impact disease progression and treatment response. However, racial and ethnic differences may influence genomic profiles, necessitating population‐specific analyses. This study aimed to character...
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| Format: | Article |
| Language: | English |
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Wiley
2025-08-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.71085 |
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| author | Shigehiro Tsukahara Masaki Shiota Shohei Nagakawa Tokiyoshi Tanegashima Satoshi Kobayashi Takashi Matsumoto Masatoshi Eto |
| author_facet | Shigehiro Tsukahara Masaki Shiota Shohei Nagakawa Tokiyoshi Tanegashima Satoshi Kobayashi Takashi Matsumoto Masatoshi Eto |
| author_sort | Shigehiro Tsukahara |
| collection | DOAJ |
| description | ABSTRACT Purpose Prostate cancer is a leading malignancy among men, and genomic alterations are known to impact disease progression and treatment response. However, racial and ethnic differences may influence genomic profiles, necessitating population‐specific analyses. This study aimed to characterize the genomic landscape and its clinical significance in Japanese patients with treatment‐resistant, unresectable prostate cancer using data from the Center for Cancer Genomics and Advanced Therapeutics (C‐CAT) database. Methods We analyzed data from patients with advanced or metastatic prostate cancer who had progressed after standard therapies and underwent comprehensive genomic profiling between 2019 and 2022. We assessed the frequency of genomic alterations, tumor mutation burden (TMB), and microsatellite instability (MSI) status. Associations between genomic features and clinical outcomes were also examined. Results A total of 2634 patients were included. Family history was reported in 12.5% for prostate cancer, 1.5% for breast cancer, 5.2% for pancreatic cancer, and 1.1% for ovarian cancer. AR gene alterations were observed in 18% of patients. TP53 and BRCA2 mutations were identified in 34% and 12% of cases, respectively. Mutations in TP53, as well as alterations in genes related to the cell cycle, epigenetic regulation, MYC signaling, and the PI3K pathway, were associated with poorer overall survival. Conclusions This study provides a comprehensive overview of genomic alterations in advanced prostate cancer among Japanese patients and identifies key mutations linked to prognosis. These findings highlight the value of personalized prognostic assessment based on genomic profiling to guide clinical decision‐making in this population. |
| format | Article |
| id | doaj-art-2cbcdb0556c7483aa76a17f381c23867 |
| institution | Kabale University |
| issn | 2045-7634 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj-art-2cbcdb0556c7483aa76a17f381c238672025-08-20T04:03:08ZengWileyCancer Medicine2045-76342025-08-011415n/an/a10.1002/cam4.71085Nationwide Genomic Data Analysis of Japanese Prostate Cancer Patients From C‐CAT DatabaseShigehiro Tsukahara0Masaki Shiota1Shohei Nagakawa2Tokiyoshi Tanegashima3Satoshi Kobayashi4Takashi Matsumoto5Masatoshi Eto6Department of Urology, Graduate School of Medical Sciences Kyushu University Fukuoka JapanDepartment of Urology, Graduate School of Medical Sciences Kyushu University Fukuoka JapanDepartment of Urology, Graduate School of Medical Sciences Kyushu University Fukuoka JapanDepartment of Urology, Graduate School of Medical Sciences Kyushu University Fukuoka JapanDepartment of Urology, Graduate School of Medical Sciences Kyushu University Fukuoka JapanDepartment of Urology, Graduate School of Medical Sciences Kyushu University Fukuoka JapanDepartment of Urology, Graduate School of Medical Sciences Kyushu University Fukuoka JapanABSTRACT Purpose Prostate cancer is a leading malignancy among men, and genomic alterations are known to impact disease progression and treatment response. However, racial and ethnic differences may influence genomic profiles, necessitating population‐specific analyses. This study aimed to characterize the genomic landscape and its clinical significance in Japanese patients with treatment‐resistant, unresectable prostate cancer using data from the Center for Cancer Genomics and Advanced Therapeutics (C‐CAT) database. Methods We analyzed data from patients with advanced or metastatic prostate cancer who had progressed after standard therapies and underwent comprehensive genomic profiling between 2019 and 2022. We assessed the frequency of genomic alterations, tumor mutation burden (TMB), and microsatellite instability (MSI) status. Associations between genomic features and clinical outcomes were also examined. Results A total of 2634 patients were included. Family history was reported in 12.5% for prostate cancer, 1.5% for breast cancer, 5.2% for pancreatic cancer, and 1.1% for ovarian cancer. AR gene alterations were observed in 18% of patients. TP53 and BRCA2 mutations were identified in 34% and 12% of cases, respectively. Mutations in TP53, as well as alterations in genes related to the cell cycle, epigenetic regulation, MYC signaling, and the PI3K pathway, were associated with poorer overall survival. Conclusions This study provides a comprehensive overview of genomic alterations in advanced prostate cancer among Japanese patients and identifies key mutations linked to prognosis. These findings highlight the value of personalized prognostic assessment based on genomic profiling to guide clinical decision‐making in this population.https://doi.org/10.1002/cam4.71085cancerC‐CATCGPcomprehensive genome profilingprostate |
| spellingShingle | Shigehiro Tsukahara Masaki Shiota Shohei Nagakawa Tokiyoshi Tanegashima Satoshi Kobayashi Takashi Matsumoto Masatoshi Eto Nationwide Genomic Data Analysis of Japanese Prostate Cancer Patients From C‐CAT Database Cancer Medicine cancer C‐CAT CGP comprehensive genome profiling prostate |
| title | Nationwide Genomic Data Analysis of Japanese Prostate Cancer Patients From C‐CAT Database |
| title_full | Nationwide Genomic Data Analysis of Japanese Prostate Cancer Patients From C‐CAT Database |
| title_fullStr | Nationwide Genomic Data Analysis of Japanese Prostate Cancer Patients From C‐CAT Database |
| title_full_unstemmed | Nationwide Genomic Data Analysis of Japanese Prostate Cancer Patients From C‐CAT Database |
| title_short | Nationwide Genomic Data Analysis of Japanese Prostate Cancer Patients From C‐CAT Database |
| title_sort | nationwide genomic data analysis of japanese prostate cancer patients from c cat database |
| topic | cancer C‐CAT CGP comprehensive genome profiling prostate |
| url | https://doi.org/10.1002/cam4.71085 |
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