Gastrointestinal Bleeding: a Cardiologist's Point of View
Oral anticoagulant therapy is widely used in different patients for the prevention and treatment of thromboembolic events: in atrial fibrillation, deep vein thrombosis/pulmonary embolism, acute coronary syndrome, in the early postoperative period after orthopedic surgery. Nowadays it is possible to...
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| Format: | Article |
| Language: | English |
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Столичная издательская компания
2021-11-01
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| Series: | Рациональная фармакотерапия в кардиологии |
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| Online Access: | https://www.rpcardio.online/jour/article/view/2590 |
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| author | O. V. Averkov L. N. Mishchenko |
| author_facet | O. V. Averkov L. N. Mishchenko |
| author_sort | O. V. Averkov |
| collection | DOAJ |
| description | Oral anticoagulant therapy is widely used in different patients for the prevention and treatment of thromboembolic events: in atrial fibrillation, deep vein thrombosis/pulmonary embolism, acute coronary syndrome, in the early postoperative period after orthopedic surgery. Nowadays it is possible to use vitamin K antagonists (warfarin) as well as direct oral anticoagulants (DOAC): dabigatran, rivaroxaban, apixaban and edoxaban. The mai complication of any anticoagulant therapy is bleeding (gastrointestinal, intracranial, etc.), which seriously limits its usage. In this review the incidence of gastrointestinal bleeding (GIB) associated with oral anticoagulants intake was analyzed according to the results of both large randomized and postregistration trials. Furthermore, the effect of age on the risk of GIB development is discussed, and also aspects of the pathophysiology of gastrointestinal mucosa lesions in patients taking DOAC are considered. |
| format | Article |
| id | doaj-art-2cbb3460eac94cb09fa432a441ea84c2 |
| institution | Kabale University |
| issn | 1819-6446 2225-3653 |
| language | English |
| publishDate | 2021-11-01 |
| publisher | Столичная издательская компания |
| record_format | Article |
| series | Рациональная фармакотерапия в кардиологии |
| spelling | doaj-art-2cbb3460eac94cb09fa432a441ea84c22025-08-23T10:00:34ZengСтоличная издательская компанияРациональная фармакотерапия в кардиологии1819-64462225-36532021-11-0117577177810.20996/1819-6446-2021-10-011955Gastrointestinal Bleeding: a Cardiologist's Point of ViewO. V. Averkov0L. N. Mishchenko1Moscow City Clinical Hospital №15 n.a. O. M. FilatovaMoscow City Clinical Hospital №15 n.a. O. M. FilatovaOral anticoagulant therapy is widely used in different patients for the prevention and treatment of thromboembolic events: in atrial fibrillation, deep vein thrombosis/pulmonary embolism, acute coronary syndrome, in the early postoperative period after orthopedic surgery. Nowadays it is possible to use vitamin K antagonists (warfarin) as well as direct oral anticoagulants (DOAC): dabigatran, rivaroxaban, apixaban and edoxaban. The mai complication of any anticoagulant therapy is bleeding (gastrointestinal, intracranial, etc.), which seriously limits its usage. In this review the incidence of gastrointestinal bleeding (GIB) associated with oral anticoagulants intake was analyzed according to the results of both large randomized and postregistration trials. Furthermore, the effect of age on the risk of GIB development is discussed, and also aspects of the pathophysiology of gastrointestinal mucosa lesions in patients taking DOAC are considered.https://www.rpcardio.online/jour/article/view/2590anticoagulant therapygastrointestinal bleedingwarfarindirect selective anticoagulantsadverse events |
| spellingShingle | O. V. Averkov L. N. Mishchenko Gastrointestinal Bleeding: a Cardiologist's Point of View Рациональная фармакотерапия в кардиологии anticoagulant therapy gastrointestinal bleeding warfarin direct selective anticoagulants adverse events |
| title | Gastrointestinal Bleeding: a Cardiologist's Point of View |
| title_full | Gastrointestinal Bleeding: a Cardiologist's Point of View |
| title_fullStr | Gastrointestinal Bleeding: a Cardiologist's Point of View |
| title_full_unstemmed | Gastrointestinal Bleeding: a Cardiologist's Point of View |
| title_short | Gastrointestinal Bleeding: a Cardiologist's Point of View |
| title_sort | gastrointestinal bleeding a cardiologist s point of view |
| topic | anticoagulant therapy gastrointestinal bleeding warfarin direct selective anticoagulants adverse events |
| url | https://www.rpcardio.online/jour/article/view/2590 |
| work_keys_str_mv | AT ovaverkov gastrointestinalbleedingacardiologistspointofview AT lnmishchenko gastrointestinalbleedingacardiologistspointofview |