Association of nephrolithiasis with the risk of cardiovascular diseases: a longitudinal follow-up study using a national health screening cohort
Objectives The aim of this study was to explore the associations of stroke and ischaemic heart disease in patients with nephrolithiasis.Design A longitudinal follow-up study.Setting Data from the Korean National Health Insurance Service–Health Screening Cohort (2002–2013) were retrieved to identify...
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BMJ Publishing Group
2020-11-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/10/11/e040034.full |
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| author | Hyo Geun Choi So Young Kim Chanyang Min Woo Jin Bang |
| author_facet | Hyo Geun Choi So Young Kim Chanyang Min Woo Jin Bang |
| author_sort | Hyo Geun Choi |
| collection | DOAJ |
| description | Objectives The aim of this study was to explore the associations of stroke and ischaemic heart disease in patients with nephrolithiasis.Design A longitudinal follow-up study.Setting Data from the Korean National Health Insurance Service–Health Screening Cohort (2002–2013) were retrieved to identify the occurrence of nephrolithiasis.Participants and interventions In total, 19 103 patients with nephrolithiasis were matched at a 1:4 ratio with control participants for age, sex, income and region of residence.Primary and secondary outcome measures The occurrence of stroke and ischaemic heart disease was analysed in both patients with nephrolithiasis and control participants. The primary outcome was HRs of stroke and ischaemic heart disease in a stratified Cox proportional hazards model. Smoking, alcohol consumption, obesity and Charlson Comorbidity Index were adjusted for as covariates. Subgroup analyses according to age and sex were also performed.Results Eight per cent (1615/19 103) of patients with nephrolithiasis and 7.2% (5476/76 412) of control participants had stroke. Nine per cent (1879/19 103) of patients with nephrolithiasis and 7.7% (5895/76 412) of control participants had ischaemic heart disease. Patients with nephrolithiasis had risks of stroke and ischaemic heart disease that were 1.18 times (95% CI=1.11 to 1.24) and 1.24 times (95% CI=1.18 to 1.31) those of the control participants, respectively. The age and sex subgroups showed consistent results.Conclusions Nephrolithiasis was associated with increased risks of stroke and ischaemic heart disease. |
| format | Article |
| id | doaj-art-2cb6ac0c974c4515806edb4ad2f1bb96 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2020-11-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-2cb6ac0c974c4515806edb4ad2f1bb962024-11-26T21:25:09ZengBMJ Publishing GroupBMJ Open2044-60552020-11-01101110.1136/bmjopen-2020-040034Association of nephrolithiasis with the risk of cardiovascular diseases: a longitudinal follow-up study using a national health screening cohortHyo Geun Choi0So Young Kim1Chanyang Min2Woo Jin Bang33 Department of Otorhinolaryngology-Head & Neck Surgery, Hallym University Sacred Heart Hospital, Anyang, Republic of KoreaInstitutes of Health & Science Convergence, Chungbuk National University, Cheongju, KoreaHallym University Sacred Heart Hospital, Anyang, Gyeonggi-do, Republic of KoreaDepartment of Urology, Hallym University College of Medicine, Anyang-si, Gyeonggi-do, The Republic of KoreaObjectives The aim of this study was to explore the associations of stroke and ischaemic heart disease in patients with nephrolithiasis.Design A longitudinal follow-up study.Setting Data from the Korean National Health Insurance Service–Health Screening Cohort (2002–2013) were retrieved to identify the occurrence of nephrolithiasis.Participants and interventions In total, 19 103 patients with nephrolithiasis were matched at a 1:4 ratio with control participants for age, sex, income and region of residence.Primary and secondary outcome measures The occurrence of stroke and ischaemic heart disease was analysed in both patients with nephrolithiasis and control participants. The primary outcome was HRs of stroke and ischaemic heart disease in a stratified Cox proportional hazards model. Smoking, alcohol consumption, obesity and Charlson Comorbidity Index were adjusted for as covariates. Subgroup analyses according to age and sex were also performed.Results Eight per cent (1615/19 103) of patients with nephrolithiasis and 7.2% (5476/76 412) of control participants had stroke. Nine per cent (1879/19 103) of patients with nephrolithiasis and 7.7% (5895/76 412) of control participants had ischaemic heart disease. Patients with nephrolithiasis had risks of stroke and ischaemic heart disease that were 1.18 times (95% CI=1.11 to 1.24) and 1.24 times (95% CI=1.18 to 1.31) those of the control participants, respectively. The age and sex subgroups showed consistent results.Conclusions Nephrolithiasis was associated with increased risks of stroke and ischaemic heart disease.https://bmjopen.bmj.com/content/10/11/e040034.full |
| spellingShingle | Hyo Geun Choi So Young Kim Chanyang Min Woo Jin Bang Association of nephrolithiasis with the risk of cardiovascular diseases: a longitudinal follow-up study using a national health screening cohort BMJ Open |
| title | Association of nephrolithiasis with the risk of cardiovascular diseases: a longitudinal follow-up study using a national health screening cohort |
| title_full | Association of nephrolithiasis with the risk of cardiovascular diseases: a longitudinal follow-up study using a national health screening cohort |
| title_fullStr | Association of nephrolithiasis with the risk of cardiovascular diseases: a longitudinal follow-up study using a national health screening cohort |
| title_full_unstemmed | Association of nephrolithiasis with the risk of cardiovascular diseases: a longitudinal follow-up study using a national health screening cohort |
| title_short | Association of nephrolithiasis with the risk of cardiovascular diseases: a longitudinal follow-up study using a national health screening cohort |
| title_sort | association of nephrolithiasis with the risk of cardiovascular diseases a longitudinal follow up study using a national health screening cohort |
| url | https://bmjopen.bmj.com/content/10/11/e040034.full |
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