MSC-derived extracellular vesicles: Precision miRNA delivery for overcoming cancer therapy resistance
Cancer remains a prominent worldwide health concern, presenting existing therapies with frequent difficulties, including major toxicity, limited effectiveness, and treatment resistance emergence. These issues highlight the necessity for novel and enhanced remedies. Exosomes, tiny extracellular vesic...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Regenerative Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352320425000604 |
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| author | Ahsas Goyal Muhammad Afzal Kavita Goyal Subbulakshmi Ganesan Mukesh Kumari S. Sunitha Aniruddh Dash Suman Saini Mohit Rana Gaurav Gupta Haider Ali Ling Shing Wong Vinoth Kumarasamy Vetriselvan Subramaniyan |
| author_facet | Ahsas Goyal Muhammad Afzal Kavita Goyal Subbulakshmi Ganesan Mukesh Kumari S. Sunitha Aniruddh Dash Suman Saini Mohit Rana Gaurav Gupta Haider Ali Ling Shing Wong Vinoth Kumarasamy Vetriselvan Subramaniyan |
| author_sort | Ahsas Goyal |
| collection | DOAJ |
| description | Cancer remains a prominent worldwide health concern, presenting existing therapies with frequent difficulties, including major toxicity, limited effectiveness, and treatment resistance emergence. These issues highlight the necessity for novel and enhanced remedies. Exosomes, tiny extracellular vesicles that facilitate intercellular communication, have attracted interest for their potential medicinal applications. Carrying a variety of molecules, including microRNAs, small interfering RNAs, long non-coding RNAs, proteins, lipids, and DNA, these vesicles are positioned as promising cancer treatment options. Current studies have increasingly investigated the capacity of microRNAs as a strategic approach for combating malignancy. Mesenchymal stem cells (MSC) are recognized for their aptitude to augment blood vessel formation, safeguard against cellular death, and modulate immune responses. Consequently, researchers examine exosomes derived from MSCs as a safer, non-cellular choice over therapies employing MSCs, which risk undesirable differentiation. The focus is shifting towards employing miRNA-encapsulated exosomes sourced from MSCs to target and heal cancerous cells selectively. However, the exact functions of miRNAs within MSC-derived exosomes in the context of cancer are still not fully understood. Additional exploration is necessary to clarify the role of these miRNAs in malignancy progression and to pinpoint viable therapeutic targets. This review offers a comprehensive examination of exosomes derived from mesenchymal stem cells, focusing on the encapsulation of miRNAs, methods for enhancing cellular uptake and stability, and their potential applications in cancer treatment. It also addresses the difficulties linked to this methodology and considers future avenues, including insights from current clinical oncology research. |
| format | Article |
| id | doaj-art-2cb5b27a96dc42559b6151d01e8f09ac |
| institution | OA Journals |
| issn | 2352-3204 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Regenerative Therapy |
| spelling | doaj-art-2cb5b27a96dc42559b6151d01e8f09ac2025-08-20T02:15:37ZengElsevierRegenerative Therapy2352-32042025-06-012930331810.1016/j.reth.2025.03.006MSC-derived extracellular vesicles: Precision miRNA delivery for overcoming cancer therapy resistanceAhsas Goyal0Muhammad Afzal1Kavita Goyal2Subbulakshmi Ganesan3Mukesh Kumari4S. Sunitha5Aniruddh Dash6Suman Saini7Mohit Rana8Gaurav Gupta9Haider Ali10Ling Shing Wong11Vinoth Kumarasamy12Vetriselvan Subramaniyan13Institute of Pharmaceutical Research, GLA University, Mathura, UP, IndiaDepartment of Pharmaceutical Sciences, Pharmacy Program, Batterjee Medical College, P.O. Box 6231, Jeddah, 21442, Saudi ArabiaDepartment of Biotechnology, Graphic Era (Deemed to be University), Clement Town, 248002, Dehradun, IndiaDepartment of Chemistry and Biochemistry, School of Sciences, JAIN (Deemed to be University), Bangalore, Karnataka, IndiaDepartment of Applied Sciences-Chemistry, NIMS Institute of Engineering & Technology, NIMS University Rajasthan, Jaipur, IndiaDepartment of CHEMISTRY, Sathyabama Institute of Science and Technology, Chennai, Tamil Nadu, IndiaDepartment of Orthopaedics IMS and SUM Hospital, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar, Odisha, 751030, IndiaDepartment of Chemistry, Chandigarh Engineering College, Chandigarh Group of Colleges-Jhanjeri, Mohali, 140307, Punjab, IndiaUttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, IndiaCentre for Research Impact & Outcome, Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab, 140401, India; Centre of Medical and Bio-allied Health Sciences Research, Ajman University, Ajman, United Arab EmiratesCentre for Global Health Research, Saveetha Medical College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IndiaFaculty of Health and Life Sciences, INTI International University, Nilai, 71800, MalaysiaDepartment of Parasitology and Medical Entomology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Cheras, 56000, Kuala Lumpur, Malaysia; Corresponding author.Department of Medical Sciences, School of Medical and Life Sciences, Sunway University, Bandar Sunway, 47500, Subang Jaya, Selangor, MalaysiaCancer remains a prominent worldwide health concern, presenting existing therapies with frequent difficulties, including major toxicity, limited effectiveness, and treatment resistance emergence. These issues highlight the necessity for novel and enhanced remedies. Exosomes, tiny extracellular vesicles that facilitate intercellular communication, have attracted interest for their potential medicinal applications. Carrying a variety of molecules, including microRNAs, small interfering RNAs, long non-coding RNAs, proteins, lipids, and DNA, these vesicles are positioned as promising cancer treatment options. Current studies have increasingly investigated the capacity of microRNAs as a strategic approach for combating malignancy. Mesenchymal stem cells (MSC) are recognized for their aptitude to augment blood vessel formation, safeguard against cellular death, and modulate immune responses. Consequently, researchers examine exosomes derived from MSCs as a safer, non-cellular choice over therapies employing MSCs, which risk undesirable differentiation. The focus is shifting towards employing miRNA-encapsulated exosomes sourced from MSCs to target and heal cancerous cells selectively. However, the exact functions of miRNAs within MSC-derived exosomes in the context of cancer are still not fully understood. Additional exploration is necessary to clarify the role of these miRNAs in malignancy progression and to pinpoint viable therapeutic targets. This review offers a comprehensive examination of exosomes derived from mesenchymal stem cells, focusing on the encapsulation of miRNAs, methods for enhancing cellular uptake and stability, and their potential applications in cancer treatment. It also addresses the difficulties linked to this methodology and considers future avenues, including insights from current clinical oncology research.http://www.sciencedirect.com/science/article/pii/S2352320425000604Cancer therapyMesenchymal stem cellsExtracellular vesiclesMicroRNA deliveryTargeted therapy |
| spellingShingle | Ahsas Goyal Muhammad Afzal Kavita Goyal Subbulakshmi Ganesan Mukesh Kumari S. Sunitha Aniruddh Dash Suman Saini Mohit Rana Gaurav Gupta Haider Ali Ling Shing Wong Vinoth Kumarasamy Vetriselvan Subramaniyan MSC-derived extracellular vesicles: Precision miRNA delivery for overcoming cancer therapy resistance Regenerative Therapy Cancer therapy Mesenchymal stem cells Extracellular vesicles MicroRNA delivery Targeted therapy |
| title | MSC-derived extracellular vesicles: Precision miRNA delivery for overcoming cancer therapy resistance |
| title_full | MSC-derived extracellular vesicles: Precision miRNA delivery for overcoming cancer therapy resistance |
| title_fullStr | MSC-derived extracellular vesicles: Precision miRNA delivery for overcoming cancer therapy resistance |
| title_full_unstemmed | MSC-derived extracellular vesicles: Precision miRNA delivery for overcoming cancer therapy resistance |
| title_short | MSC-derived extracellular vesicles: Precision miRNA delivery for overcoming cancer therapy resistance |
| title_sort | msc derived extracellular vesicles precision mirna delivery for overcoming cancer therapy resistance |
| topic | Cancer therapy Mesenchymal stem cells Extracellular vesicles MicroRNA delivery Targeted therapy |
| url | http://www.sciencedirect.com/science/article/pii/S2352320425000604 |
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