Combined inhibition of p97 and the proteasome causes lethal disruption of the secretory apparatus in multiple myeloma cells.

Combined inhibition of p97 and the proteasome causes lethal disruption of the secretory apparatus in multiple myeloma cells.

Inhibition of the proteasome is a widely used strategy for treating multiple myeloma that takes advantage of the heavy secretory load that multiple myeloma cells (MMCs) have to deal with. Resistance of MMCs to proteasome inhibition has been linked to incomplete disruption of proteasomal endoplasmic-...

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Main Authors: Holger W Auner, Anne Marie Moody, Theresa H Ward, Marianne Kraus, Enrico Milan, Philippa May, Aristeidis Chaidos, Christoph Driessen, Simone Cenci, Francesco Dazzi, Amin Rahemtulla, Jane F Apperley, Anastasios Karadimitris, Niall Dillon
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0074415
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