Association of estimated glucose disposal rate with metabolic syndrome prevalence and mortality risks: a population-based study
Abstract Background Insulin resistance (IR) is a central pathophysiological factor in metabolic syndrome (MetS) and an essential driver of cardiovascular disease (CVD) and mortality. The estimated glucose disposal rate (eGDR) is a reliable marker of IR and has been associated with CVD prognosis. Thi...
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BMC
2025-01-01
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| Series: | Cardiovascular Diabetology |
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| Online Access: | https://doi.org/10.1186/s12933-025-02599-7 |
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| author | Xiaoli Chen Aihua Li Qilin Ma |
| author_facet | Xiaoli Chen Aihua Li Qilin Ma |
| author_sort | Xiaoli Chen |
| collection | DOAJ |
| description | Abstract Background Insulin resistance (IR) is a central pathophysiological factor in metabolic syndrome (MetS) and an essential driver of cardiovascular disease (CVD) and mortality. The estimated glucose disposal rate (eGDR) is a reliable marker of IR and has been associated with CVD prognosis. This study aims to examine the relationship between eGDR, MetS, and their predictive roles in clinical outcomes. Methods Data from the NHANES (2001–2018) were utilized, with a cross-sectional design applied to evaluate the association between eGDR and MetS prevalence, and a cohort design employed for mortality follow-up. Weighted logistic regression models were used to examine the association between eGDR and MetS. Weighted Cox proportional hazard models were applied to assess the link between eGDR and both all-cause and CVD mortality. To examine the non-linear associations between the eGDR, MetS, and mortality outcomes, restricted cubic spline (RCS) analysis was applied. Additionally, the predictive performance of eGDR, and other IR indices (TyG, HOMA-IR), for mortality was assessed using the C-statistic. Results A robust negative association between eGDR and MetS prevalence was found, following full covariate adjustment (p < 0.001). The core findings were consistent across subgroups (all p < 0.001). Cox regression analysis indicated that in individuals with MetS, each standard deviation (SD) increment in eGDR was associated with an 11% and 18% decrement in the risk of all-cause and CVD mortality, respectively. RCS analysis displayed a non-linear association between eGDR and MetS prevalence, while a linear association between eGDR and mortality. The C-statistic showed that eGDR, compared to the TyG index and HOMA-IR, significantly improved predictive power for all-cause mortality (p = 0.007). Conclusion eGDR is strongly associated with MetS and predicts all-cause and CVD mortality in individuals with MetS. Compared to TyG and HOMA-IR, eGDR offers superior predictive value for all-cause mortality, highlighting its potential as a useful tool in clinical risk assessment. |
| format | Article |
| id | doaj-art-2cb42e94e217402d9a69fc22b38cdff2 |
| institution | Kabale University |
| issn | 1475-2840 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Diabetology |
| spelling | doaj-art-2cb42e94e217402d9a69fc22b38cdff22025-01-26T12:13:42ZengBMCCardiovascular Diabetology1475-28402025-01-0124111210.1186/s12933-025-02599-7Association of estimated glucose disposal rate with metabolic syndrome prevalence and mortality risks: a population-based studyXiaoli Chen0Aihua Li1Qilin Ma2Department of Cardiovascular Medicine, Xiangya Hospital, Central South UniversityDepartment of Cardiovascular Medicine, Xiangya Hospital, Central South UniversityDepartment of Cardiovascular Medicine, Xiangya Hospital, Central South UniversityAbstract Background Insulin resistance (IR) is a central pathophysiological factor in metabolic syndrome (MetS) and an essential driver of cardiovascular disease (CVD) and mortality. The estimated glucose disposal rate (eGDR) is a reliable marker of IR and has been associated with CVD prognosis. This study aims to examine the relationship between eGDR, MetS, and their predictive roles in clinical outcomes. Methods Data from the NHANES (2001–2018) were utilized, with a cross-sectional design applied to evaluate the association between eGDR and MetS prevalence, and a cohort design employed for mortality follow-up. Weighted logistic regression models were used to examine the association between eGDR and MetS. Weighted Cox proportional hazard models were applied to assess the link between eGDR and both all-cause and CVD mortality. To examine the non-linear associations between the eGDR, MetS, and mortality outcomes, restricted cubic spline (RCS) analysis was applied. Additionally, the predictive performance of eGDR, and other IR indices (TyG, HOMA-IR), for mortality was assessed using the C-statistic. Results A robust negative association between eGDR and MetS prevalence was found, following full covariate adjustment (p < 0.001). The core findings were consistent across subgroups (all p < 0.001). Cox regression analysis indicated that in individuals with MetS, each standard deviation (SD) increment in eGDR was associated with an 11% and 18% decrement in the risk of all-cause and CVD mortality, respectively. RCS analysis displayed a non-linear association between eGDR and MetS prevalence, while a linear association between eGDR and mortality. The C-statistic showed that eGDR, compared to the TyG index and HOMA-IR, significantly improved predictive power for all-cause mortality (p = 0.007). Conclusion eGDR is strongly associated with MetS and predicts all-cause and CVD mortality in individuals with MetS. Compared to TyG and HOMA-IR, eGDR offers superior predictive value for all-cause mortality, highlighting its potential as a useful tool in clinical risk assessment.https://doi.org/10.1186/s12933-025-02599-7Insulin resistanceMetabolic syndromeEstimated glucose disposal rateNHANESMortality |
| spellingShingle | Xiaoli Chen Aihua Li Qilin Ma Association of estimated glucose disposal rate with metabolic syndrome prevalence and mortality risks: a population-based study Cardiovascular Diabetology Insulin resistance Metabolic syndrome Estimated glucose disposal rate NHANES Mortality |
| title | Association of estimated glucose disposal rate with metabolic syndrome prevalence and mortality risks: a population-based study |
| title_full | Association of estimated glucose disposal rate with metabolic syndrome prevalence and mortality risks: a population-based study |
| title_fullStr | Association of estimated glucose disposal rate with metabolic syndrome prevalence and mortality risks: a population-based study |
| title_full_unstemmed | Association of estimated glucose disposal rate with metabolic syndrome prevalence and mortality risks: a population-based study |
| title_short | Association of estimated glucose disposal rate with metabolic syndrome prevalence and mortality risks: a population-based study |
| title_sort | association of estimated glucose disposal rate with metabolic syndrome prevalence and mortality risks a population based study |
| topic | Insulin resistance Metabolic syndrome Estimated glucose disposal rate NHANES Mortality |
| url | https://doi.org/10.1186/s12933-025-02599-7 |
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