Nanoparticles induced cuproptosis to enhance antitumor immunotherapy
Abstract Immunotherapy is a highly promising cancer treatment method. However, it is limited by low immunogenicity and an immunosuppressive microenvironment, which could be relieved by immunogenic cell death (ICD). Currently, effective ICD is primarily achieved through apoptosis induction, but tumor...
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BMC
2025-07-01
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| Series: | Journal of Nanobiotechnology |
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| Online Access: | https://doi.org/10.1186/s12951-025-03616-3 |
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| author | Wen Deng Zichen Zhong Haojie Shang Yonghua Tong Qiu Huang Yu He Jian Wu Xiaozhuo Ba Zhiqiang Chen Yuan Chen Kun Tang |
| author_facet | Wen Deng Zichen Zhong Haojie Shang Yonghua Tong Qiu Huang Yu He Jian Wu Xiaozhuo Ba Zhiqiang Chen Yuan Chen Kun Tang |
| author_sort | Wen Deng |
| collection | DOAJ |
| description | Abstract Immunotherapy is a highly promising cancer treatment method. However, it is limited by low immunogenicity and an immunosuppressive microenvironment, which could be relieved by immunogenic cell death (ICD). Currently, effective ICD is primarily achieved through apoptosis induction, but tumor cells' resistance to apoptosis limits its antitumor efficacy. Therefore, developing new cell death modalities with high immunogenicity for cancer immunotherapy is of great significance. Cuproptosis, a newly discovered form of programmed cell death, can effectively circumvent tumor cells' resistance to apoptosis. Various Cu ionophores have been studied as anticancer drugs to promote cuproptosis, but the lack of tumor specificity remains one of the major challenges in this field. In contrast, nanoparticles tend to preferentially accumulate in tumor tissues due to the enhanced permeability and retention (EPR) effect, and they can be surface-modified to achieve active tumor targeting capabilities. Recently, many unique physicochemical properties of nanoparticles have been designed as nano-inducers of cuproptosis, successfully enhancing immunotherapy. Based on this, this review detailedly summarized various strategies and applications of nanoparticles-induced cuproptosis in tumor cells. The role of Cu metabolism and homeostasis in tumorigenesis and development, the molecular mechanisms of cuproptosis and different cuproptosis inducers with promising application prospects, as well as the interaction between cuproptosis and immunotherapy have also been reviewed. Finally, we presented the limitations and future prospects of cuproptosis nano-inducers, hoping to provide a new strategy to enhance antitumor immunotherapy. Graphical Abstract |
| format | Article |
| id | doaj-art-2cb40c3d5ce044dea2bb0e177f59a6ce |
| institution | Kabale University |
| issn | 1477-3155 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj-art-2cb40c3d5ce044dea2bb0e177f59a6ce2025-08-20T04:02:55ZengBMCJournal of Nanobiotechnology1477-31552025-07-0123114110.1186/s12951-025-03616-3Nanoparticles induced cuproptosis to enhance antitumor immunotherapyWen Deng0Zichen Zhong1Haojie Shang2Yonghua Tong3Qiu Huang4Yu He5Jian Wu6Xiaozhuo Ba7Zhiqiang Chen8Yuan Chen9Kun Tang10Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyAbstract Immunotherapy is a highly promising cancer treatment method. However, it is limited by low immunogenicity and an immunosuppressive microenvironment, which could be relieved by immunogenic cell death (ICD). Currently, effective ICD is primarily achieved through apoptosis induction, but tumor cells' resistance to apoptosis limits its antitumor efficacy. Therefore, developing new cell death modalities with high immunogenicity for cancer immunotherapy is of great significance. Cuproptosis, a newly discovered form of programmed cell death, can effectively circumvent tumor cells' resistance to apoptosis. Various Cu ionophores have been studied as anticancer drugs to promote cuproptosis, but the lack of tumor specificity remains one of the major challenges in this field. In contrast, nanoparticles tend to preferentially accumulate in tumor tissues due to the enhanced permeability and retention (EPR) effect, and they can be surface-modified to achieve active tumor targeting capabilities. Recently, many unique physicochemical properties of nanoparticles have been designed as nano-inducers of cuproptosis, successfully enhancing immunotherapy. Based on this, this review detailedly summarized various strategies and applications of nanoparticles-induced cuproptosis in tumor cells. The role of Cu metabolism and homeostasis in tumorigenesis and development, the molecular mechanisms of cuproptosis and different cuproptosis inducers with promising application prospects, as well as the interaction between cuproptosis and immunotherapy have also been reviewed. Finally, we presented the limitations and future prospects of cuproptosis nano-inducers, hoping to provide a new strategy to enhance antitumor immunotherapy. Graphical Abstracthttps://doi.org/10.1186/s12951-025-03616-3NanoparticlesCuproptosisImmunogenic cell deathCancer immunotherapy |
| spellingShingle | Wen Deng Zichen Zhong Haojie Shang Yonghua Tong Qiu Huang Yu He Jian Wu Xiaozhuo Ba Zhiqiang Chen Yuan Chen Kun Tang Nanoparticles induced cuproptosis to enhance antitumor immunotherapy Journal of Nanobiotechnology Nanoparticles Cuproptosis Immunogenic cell death Cancer immunotherapy |
| title | Nanoparticles induced cuproptosis to enhance antitumor immunotherapy |
| title_full | Nanoparticles induced cuproptosis to enhance antitumor immunotherapy |
| title_fullStr | Nanoparticles induced cuproptosis to enhance antitumor immunotherapy |
| title_full_unstemmed | Nanoparticles induced cuproptosis to enhance antitumor immunotherapy |
| title_short | Nanoparticles induced cuproptosis to enhance antitumor immunotherapy |
| title_sort | nanoparticles induced cuproptosis to enhance antitumor immunotherapy |
| topic | Nanoparticles Cuproptosis Immunogenic cell death Cancer immunotherapy |
| url | https://doi.org/10.1186/s12951-025-03616-3 |
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