SMRT-depleted conventional DCs maintain inflammation despite lower glycolysis via mTOR signalling and succinate oxidation

SMRT-depleted conventional DCs maintain inflammation despite lower glycolysis via mTOR signalling and succinate oxidation

Abstract Inflammatory diseases implicate a synchronised immune-metabolic rewiring to maintain homeostasis. The regulatory mechanisms governing the transcriptional control of immune-centric metabolic adjustments in dendritic cells (DCs) remains elusive. Recently we reported that Ncor2 (SMRT) loss of...

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Main Authors: Kaushik Sen, Rashmirekha Pati, Gyan Prakash Mishra, Subhasish Prusty, Sourya Prakash Nayak, Archana Tripathy, Shweta Chaudhary, Atimukta Jha, Arunita Patra, Priti Meena, Shaktiprasad Mishra, Ranjan Kumar Nanda, Alok Kumar Mantri, Bhawna Gupta, Sunil K. Raghav
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:npj Metabolic Health and Disease
Online Access:https://doi.org/10.1038/s44324-024-00034-1
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