N-Acetyl Cysteine Protects against Methamphetamine-Induced Dopaminergic Neurodegeneration via Modulation of Redox Status and Autophagy in Dopaminergic Cells

N-Acetyl Cysteine Protects against Methamphetamine-Induced Dopaminergic Neurodegeneration via Modulation of Redox Status and Autophagy in Dopaminergic Cells

Methamphetamine- (MA-) induced neurotoxicity is associated with mitochondrial dysfunction and enhanced oxidative stress. Our previous study demonstrated that MA induces autophagy in a dopaminergic neuronal cell model (N27 cells). The cellular mechanisms underlying MA-induced autophagy and apoptosis...

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Main Authors: Prashanth Chandramani Shivalingappa, Huajun Jin, Vellareddy Anantharam, Anumantha Kanthasamy, Arthi Kanthasamy
Format: Article
Language:English
Published: Wiley 2012-01-01
Series:Parkinson's Disease
Online Access:http://dx.doi.org/10.1155/2012/424285
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