Elevated Expression of CHAF1A in Hepatocellular Carcinoma Progression and Immune Modulation
Jiajing Li,1 Ting Zhang,2 Qi Liu,2 Qian Du3 1The Diagnostics Laboratory, Affiliated Hospital to Zunyi Medical University, Zunyi, Guizhou, 563000, People’s Republic of China; 2Affiliated Hospital to Zunyi Medical University, Zunyi, Guizhou, 563000, People’s Republic of China; 3Department of Endoscopy...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2025-04-01
|
| Series: | Clinical and Experimental Gastroenterology |
| Subjects: | |
| Online Access: | https://www.dovepress.com/elevated-expression-of-chaf1a-in-hepatocellular-carcinoma-progression--peer-reviewed-fulltext-article-CEG |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850040719392112640 |
|---|---|
| author | Li J Zhang T Liu Q Du Q |
| author_facet | Li J Zhang T Liu Q Du Q |
| author_sort | Li J |
| collection | DOAJ |
| description | Jiajing Li,1 Ting Zhang,2 Qi Liu,2 Qian Du3 1The Diagnostics Laboratory, Affiliated Hospital to Zunyi Medical University, Zunyi, Guizhou, 563000, People’s Republic of China; 2Affiliated Hospital to Zunyi Medical University, Zunyi, Guizhou, 563000, People’s Republic of China; 3Department of Endoscopy and Digestive System, Guizhou Provincial People’s Hospital, Guiyang, Guizhou, 550002, People’s Republic of ChinaCorrespondence: Jiajing Li, Email 253480146@qq.comPurpose: This study aimed to explore the role of CHAF1A in hepatocellular carcinoma (HCC) progression, focusing on its expression, co-expression genes, genomic alterations, promoter methylation, clinical relevance, prognostic value, and immune associations.Methods: CHAF1A mRNA expression was analyzed using UALCAN. Co-expression genes and functions were explored via LinkedOmics. Genomic alterations were assessed using cBioPortal. Promoter methylation and clinical correlations were examined using GEO datasets. Prognostic significance was evaluated via Kaplan-Meier analysis. Immune cell infiltration and checkpoint gene associations were investigated.Results: CHAF1A was significantly upregulated in HCC and involved in cancer-related pathways. Genomic alterations were prominent in T1-stage tumors, often linked to alcohol-related liver disease. Promoter methylation influenced HCC progression and prognosis. CHAF1A expression correlated with clinical characteristics (gender, stage, grade, etc.) and showed diagnostic potential (AUC = 0.795). High CHAF1A expression predicted poor prognosis across various subgroups and was positively associated with immune cell infiltration and checkpoint genes.Conclusion: CHAF1A plays a critical role in HCC progression, with elevated expression linked to poor prognosis and immune modulation. These findings highlight its potential as a therapeutic target for HCC. Keywords: CHAF1A, HCC, expression patterns, immune cell infiltration, gene |
| format | Article |
| id | doaj-art-2caeb9dabf7342ca84339484d814f837 |
| institution | DOAJ |
| issn | 1178-7023 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical and Experimental Gastroenterology |
| spelling | doaj-art-2caeb9dabf7342ca84339484d814f8372025-08-20T02:56:01ZengDove Medical PressClinical and Experimental Gastroenterology1178-70232025-04-01Volume 182540102192Elevated Expression of CHAF1A in Hepatocellular Carcinoma Progression and Immune ModulationLi JZhang TLiu QDu QJiajing Li,1 Ting Zhang,2 Qi Liu,2 Qian Du3 1The Diagnostics Laboratory, Affiliated Hospital to Zunyi Medical University, Zunyi, Guizhou, 563000, People’s Republic of China; 2Affiliated Hospital to Zunyi Medical University, Zunyi, Guizhou, 563000, People’s Republic of China; 3Department of Endoscopy and Digestive System, Guizhou Provincial People’s Hospital, Guiyang, Guizhou, 550002, People’s Republic of ChinaCorrespondence: Jiajing Li, Email 253480146@qq.comPurpose: This study aimed to explore the role of CHAF1A in hepatocellular carcinoma (HCC) progression, focusing on its expression, co-expression genes, genomic alterations, promoter methylation, clinical relevance, prognostic value, and immune associations.Methods: CHAF1A mRNA expression was analyzed using UALCAN. Co-expression genes and functions were explored via LinkedOmics. Genomic alterations were assessed using cBioPortal. Promoter methylation and clinical correlations were examined using GEO datasets. Prognostic significance was evaluated via Kaplan-Meier analysis. Immune cell infiltration and checkpoint gene associations were investigated.Results: CHAF1A was significantly upregulated in HCC and involved in cancer-related pathways. Genomic alterations were prominent in T1-stage tumors, often linked to alcohol-related liver disease. Promoter methylation influenced HCC progression and prognosis. CHAF1A expression correlated with clinical characteristics (gender, stage, grade, etc.) and showed diagnostic potential (AUC = 0.795). High CHAF1A expression predicted poor prognosis across various subgroups and was positively associated with immune cell infiltration and checkpoint genes.Conclusion: CHAF1A plays a critical role in HCC progression, with elevated expression linked to poor prognosis and immune modulation. These findings highlight its potential as a therapeutic target for HCC. Keywords: CHAF1A, HCC, expression patterns, immune cell infiltration, genehttps://www.dovepress.com/elevated-expression-of-chaf1a-in-hepatocellular-carcinoma-progression--peer-reviewed-fulltext-article-CEGchaf1ahccexpression patternsimmune cell infiltrationgene |
| spellingShingle | Li J Zhang T Liu Q Du Q Elevated Expression of CHAF1A in Hepatocellular Carcinoma Progression and Immune Modulation Clinical and Experimental Gastroenterology chaf1a hcc expression patterns immune cell infiltration gene |
| title | Elevated Expression of CHAF1A in Hepatocellular Carcinoma Progression and Immune Modulation |
| title_full | Elevated Expression of CHAF1A in Hepatocellular Carcinoma Progression and Immune Modulation |
| title_fullStr | Elevated Expression of CHAF1A in Hepatocellular Carcinoma Progression and Immune Modulation |
| title_full_unstemmed | Elevated Expression of CHAF1A in Hepatocellular Carcinoma Progression and Immune Modulation |
| title_short | Elevated Expression of CHAF1A in Hepatocellular Carcinoma Progression and Immune Modulation |
| title_sort | elevated expression of chaf1a in hepatocellular carcinoma progression and immune modulation |
| topic | chaf1a hcc expression patterns immune cell infiltration gene |
| url | https://www.dovepress.com/elevated-expression-of-chaf1a-in-hepatocellular-carcinoma-progression--peer-reviewed-fulltext-article-CEG |
| work_keys_str_mv | AT lij elevatedexpressionofchaf1ainhepatocellularcarcinomaprogressionandimmunemodulation AT zhangt elevatedexpressionofchaf1ainhepatocellularcarcinomaprogressionandimmunemodulation AT liuq elevatedexpressionofchaf1ainhepatocellularcarcinomaprogressionandimmunemodulation AT duq elevatedexpressionofchaf1ainhepatocellularcarcinomaprogressionandimmunemodulation |