Validation of an 8-item self-administered questionnaire for assessing migraine-related sensory hypersensitivities (MHQ-8)
Abstract Background In addition to headache, migraine patients often experience sensory hypersensitivity to external stimuli. While photophobia and phonophobia are part of the diagnostic criteria of migraine, many patients also exhibit cutaneous allodynia and osmophobia. However, the presence and in...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-05-01
|
| Series: | The Journal of Headache and Pain |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s10194-025-02067-3 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850243078544162816 |
|---|---|
| author | François Gabrielli Melissa Zuel Camille Magaud Sophia Sickout-Arondo Bruno Pereira Jérémie Dassa Solène De Gaalon Geneviève Demarquay Anne Donnet Anne Ducros Pierric Giraud Evelyne Guégan-Massardier Christian Lucas Jérôme Mawet Mitra Najjar Caroline Roos Elise K. Van Obberghen Christian Dualé Radhouane Dallel Xavier Moisset |
| author_facet | François Gabrielli Melissa Zuel Camille Magaud Sophia Sickout-Arondo Bruno Pereira Jérémie Dassa Solène De Gaalon Geneviève Demarquay Anne Donnet Anne Ducros Pierric Giraud Evelyne Guégan-Massardier Christian Lucas Jérôme Mawet Mitra Najjar Caroline Roos Elise K. Van Obberghen Christian Dualé Radhouane Dallel Xavier Moisset |
| author_sort | François Gabrielli |
| collection | DOAJ |
| description | Abstract Background In addition to headache, migraine patients often experience sensory hypersensitivity to external stimuli. While photophobia and phonophobia are part of the diagnostic criteria of migraine, many patients also exhibit cutaneous allodynia and osmophobia. However, the presence and intensity of these four hypersensitivities are rarely assessed systematically and simultaneously due to the lack of a simple and rapid self-report questionnaire. Methods We have identified existing questionnaires for allodynia, photophobia and phonophobia and selected one of each, that were translated in French and validated (according to COSMIN’s recommendations). We also proposed a 2-item questionnaire (presence and intensity) for each of these 3 hypersensitivities plus osmophobia, resulting in the 8-item Migraine Hypersensitivity Questionnaire (MHQ-8) exploring these four hypersensitivities. In addition, the headache impact test (HIT-6), the migraine disability assessment (MIDAS) and the hospital anxiety and depression scale (HADS) were also answered. The survey was conducted in Pain and Neurology departments during specialised consultations for headaches. Content validity, structural validity, internal consistency, transcultural validity, reliability, criterion validity, construct validity and responsiveness were tested. Confirmatory factor analysis (CFA) was used to test the dimensionality of the questionnaires. Results The study sample consisted in N = 329 patients with a mean age of 43.7 ± 13.2 and a mean number of 10.2 ± 7.0 migraine days per month; 84% of them were women and 27% had chronic migraine. Overall, 312 to 327 questionnaires were usable for the hypersensitivity questionnaires. The reliability of the MHQ-8 was good to excellent with a Cronbach’s alpha of α = 0.88 (photophobia), α = 0.89 (phonophobia), α = 0.91 (allodynia), α = 0.95 (osmophobia), and α = 0.85 for the whole questionnaire. The intraclass correlation coefficient assessing test-retest reliability was 0.83, 0.77, 0.87, and 0.90, respectively; it was 0.88 for the whole questionnaire. The factor analysis on the MHQ-8 items showed excellent exploratory results, and the indicators of the CFA showed good performances with CFI and TLI at 0.999, RMSEA at 0.054 and SRMR at 0.021. Conclusions The MHQ-8 developed in this study is valid and reliable. It serves as a new diagnostic tool for the four sensory hypersensitivities that can occur during migraine attacks and may be useful in both clinical research and daily practice. |
| format | Article |
| id | doaj-art-2cabfe88feab43bc9c55c362a618c58a |
| institution | OA Journals |
| issn | 1129-2377 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
| record_format | Article |
| series | The Journal of Headache and Pain |
| spelling | doaj-art-2cabfe88feab43bc9c55c362a618c58a2025-08-20T02:00:07ZengBMCThe Journal of Headache and Pain1129-23772025-05-0126111210.1186/s10194-025-02067-3Validation of an 8-item self-administered questionnaire for assessing migraine-related sensory hypersensitivities (MHQ-8)François Gabrielli0Melissa Zuel1Camille Magaud2Sophia Sickout-Arondo3Bruno Pereira4Jérémie Dassa5Solène De Gaalon6Geneviève Demarquay7Anne Donnet8Anne Ducros9Pierric Giraud10Evelyne Guégan-Massardier11Christian Lucas12Jérôme Mawet13Mitra Najjar14Caroline Roos15Elise K. Van Obberghen16Christian Dualé17Radhouane Dallel18Xavier Moisset19Université Clermont Auvergne, CHU Clermont-Ferrand, Neuro-Dol, InsermUniversité Clermont Auvergne, CHU Clermont-Ferrand, Neuro-Dol, InsermUniversité Clermont Auvergne, CHU Clermont-Ferrand, Neuro-Dol, InsermUniversité Clermont Auvergne, CHU Clermont-Ferrand, Neuro-Dol, InsermBiostatistics Unit (DRCI), CHU Clermont-FerrandService de Neurologie, CH Le Puy en VelayDepartment of Neurology, CHU de NantesHospices Civils de Lyon, University of LyonUniversité Clermont Auvergne, CHU Clermont-Ferrand, Neuro-Dol, InsermDepartment of Neurology, Gui-de-Chauliac Hospital, CHU de Montpellier, University of MontpellierDepartment of Neurology, Annecy Genevois HospitalDepartment of Neurology, Rouen University HospitalPain Department, Service de Neurochirurgie, Hôpital Salengro, CHU de LilleEmergency Headache Center (Centre d’Urgences Céphalées), Department of Neurology, Lariboisière Hospital, Assistance publique des Hôpitaux de ParisService de Neurologie, CH VichyEmergency Headache Center (Centre d’Urgences Céphalées), Department of Neurology, Lariboisière Hospital, Assistance publique des Hôpitaux de ParisPain Department and FHU InovPain, CHU de Nice, Côte Azur UniversitéUniversité Clermont Auvergne, CHU Clermont-Ferrand, Neuro-Dol, InsermUniversité Clermont Auvergne, CHU Clermont-Ferrand, Neuro-Dol, InsermUniversité Clermont Auvergne, CHU Clermont-Ferrand, Neuro-Dol, InsermAbstract Background In addition to headache, migraine patients often experience sensory hypersensitivity to external stimuli. While photophobia and phonophobia are part of the diagnostic criteria of migraine, many patients also exhibit cutaneous allodynia and osmophobia. However, the presence and intensity of these four hypersensitivities are rarely assessed systematically and simultaneously due to the lack of a simple and rapid self-report questionnaire. Methods We have identified existing questionnaires for allodynia, photophobia and phonophobia and selected one of each, that were translated in French and validated (according to COSMIN’s recommendations). We also proposed a 2-item questionnaire (presence and intensity) for each of these 3 hypersensitivities plus osmophobia, resulting in the 8-item Migraine Hypersensitivity Questionnaire (MHQ-8) exploring these four hypersensitivities. In addition, the headache impact test (HIT-6), the migraine disability assessment (MIDAS) and the hospital anxiety and depression scale (HADS) were also answered. The survey was conducted in Pain and Neurology departments during specialised consultations for headaches. Content validity, structural validity, internal consistency, transcultural validity, reliability, criterion validity, construct validity and responsiveness were tested. Confirmatory factor analysis (CFA) was used to test the dimensionality of the questionnaires. Results The study sample consisted in N = 329 patients with a mean age of 43.7 ± 13.2 and a mean number of 10.2 ± 7.0 migraine days per month; 84% of them were women and 27% had chronic migraine. Overall, 312 to 327 questionnaires were usable for the hypersensitivity questionnaires. The reliability of the MHQ-8 was good to excellent with a Cronbach’s alpha of α = 0.88 (photophobia), α = 0.89 (phonophobia), α = 0.91 (allodynia), α = 0.95 (osmophobia), and α = 0.85 for the whole questionnaire. The intraclass correlation coefficient assessing test-retest reliability was 0.83, 0.77, 0.87, and 0.90, respectively; it was 0.88 for the whole questionnaire. The factor analysis on the MHQ-8 items showed excellent exploratory results, and the indicators of the CFA showed good performances with CFI and TLI at 0.999, RMSEA at 0.054 and SRMR at 0.021. Conclusions The MHQ-8 developed in this study is valid and reliable. It serves as a new diagnostic tool for the four sensory hypersensitivities that can occur during migraine attacks and may be useful in both clinical research and daily practice.https://doi.org/10.1186/s10194-025-02067-3AllodyniaPhotophobiaPhonophobiaOsmophobiaMigrainePsychometric |
| spellingShingle | François Gabrielli Melissa Zuel Camille Magaud Sophia Sickout-Arondo Bruno Pereira Jérémie Dassa Solène De Gaalon Geneviève Demarquay Anne Donnet Anne Ducros Pierric Giraud Evelyne Guégan-Massardier Christian Lucas Jérôme Mawet Mitra Najjar Caroline Roos Elise K. Van Obberghen Christian Dualé Radhouane Dallel Xavier Moisset Validation of an 8-item self-administered questionnaire for assessing migraine-related sensory hypersensitivities (MHQ-8) The Journal of Headache and Pain Allodynia Photophobia Phonophobia Osmophobia Migraine Psychometric |
| title | Validation of an 8-item self-administered questionnaire for assessing migraine-related sensory hypersensitivities (MHQ-8) |
| title_full | Validation of an 8-item self-administered questionnaire for assessing migraine-related sensory hypersensitivities (MHQ-8) |
| title_fullStr | Validation of an 8-item self-administered questionnaire for assessing migraine-related sensory hypersensitivities (MHQ-8) |
| title_full_unstemmed | Validation of an 8-item self-administered questionnaire for assessing migraine-related sensory hypersensitivities (MHQ-8) |
| title_short | Validation of an 8-item self-administered questionnaire for assessing migraine-related sensory hypersensitivities (MHQ-8) |
| title_sort | validation of an 8 item self administered questionnaire for assessing migraine related sensory hypersensitivities mhq 8 |
| topic | Allodynia Photophobia Phonophobia Osmophobia Migraine Psychometric |
| url | https://doi.org/10.1186/s10194-025-02067-3 |
| work_keys_str_mv | AT francoisgabrielli validationofan8itemselfadministeredquestionnaireforassessingmigrainerelatedsensoryhypersensitivitiesmhq8 AT melissazuel validationofan8itemselfadministeredquestionnaireforassessingmigrainerelatedsensoryhypersensitivitiesmhq8 AT camillemagaud validationofan8itemselfadministeredquestionnaireforassessingmigrainerelatedsensoryhypersensitivitiesmhq8 AT sophiasickoutarondo validationofan8itemselfadministeredquestionnaireforassessingmigrainerelatedsensoryhypersensitivitiesmhq8 AT brunopereira validationofan8itemselfadministeredquestionnaireforassessingmigrainerelatedsensoryhypersensitivitiesmhq8 AT jeremiedassa validationofan8itemselfadministeredquestionnaireforassessingmigrainerelatedsensoryhypersensitivitiesmhq8 AT solenedegaalon validationofan8itemselfadministeredquestionnaireforassessingmigrainerelatedsensoryhypersensitivitiesmhq8 AT genevievedemarquay validationofan8itemselfadministeredquestionnaireforassessingmigrainerelatedsensoryhypersensitivitiesmhq8 AT annedonnet validationofan8itemselfadministeredquestionnaireforassessingmigrainerelatedsensoryhypersensitivitiesmhq8 AT anneducros validationofan8itemselfadministeredquestionnaireforassessingmigrainerelatedsensoryhypersensitivitiesmhq8 AT pierricgiraud validationofan8itemselfadministeredquestionnaireforassessingmigrainerelatedsensoryhypersensitivitiesmhq8 AT evelynegueganmassardier validationofan8itemselfadministeredquestionnaireforassessingmigrainerelatedsensoryhypersensitivitiesmhq8 AT christianlucas validationofan8itemselfadministeredquestionnaireforassessingmigrainerelatedsensoryhypersensitivitiesmhq8 AT jeromemawet validationofan8itemselfadministeredquestionnaireforassessingmigrainerelatedsensoryhypersensitivitiesmhq8 AT mitranajjar validationofan8itemselfadministeredquestionnaireforassessingmigrainerelatedsensoryhypersensitivitiesmhq8 AT carolineroos validationofan8itemselfadministeredquestionnaireforassessingmigrainerelatedsensoryhypersensitivitiesmhq8 AT elisekvanobberghen validationofan8itemselfadministeredquestionnaireforassessingmigrainerelatedsensoryhypersensitivitiesmhq8 AT christianduale validationofan8itemselfadministeredquestionnaireforassessingmigrainerelatedsensoryhypersensitivitiesmhq8 AT radhouanedallel validationofan8itemselfadministeredquestionnaireforassessingmigrainerelatedsensoryhypersensitivitiesmhq8 AT xaviermoisset validationofan8itemselfadministeredquestionnaireforassessingmigrainerelatedsensoryhypersensitivitiesmhq8 |