Bio-inspired electronics: Soft, biohybrid, and “living” neural interfaces
Abstract Neural interface technologies are increasingly evolving towards bio-inspired approaches to enhance integration and long-term functionality. Recent strategies merge soft materials with tissue engineering to realize biologically-active and/or cell-containing living layers at the tissue-device...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-57016-0 |
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| _version_ | 1849723999661064192 |
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| author | Dimitris Boufidis Raghav Garg Eugenia Angelopoulos D. Kacy Cullen Flavia Vitale |
| author_facet | Dimitris Boufidis Raghav Garg Eugenia Angelopoulos D. Kacy Cullen Flavia Vitale |
| author_sort | Dimitris Boufidis |
| collection | DOAJ |
| description | Abstract Neural interface technologies are increasingly evolving towards bio-inspired approaches to enhance integration and long-term functionality. Recent strategies merge soft materials with tissue engineering to realize biologically-active and/or cell-containing living layers at the tissue-device interface that enable seamless biointegration and novel cell-mediated therapeutic opportunities. This review maps the field of bio-inspired electronics and discusses key recent developments in tissue-like and regenerative bioelectronics, from soft biomaterials and surface-functionalized bioactive coatings to cell-containing ‘biohybrid’ and ‘all-living’ interfaces. We define and contextualize key terminology in this emerging field and highlight how biological and living components can bridge the gap to clinical translation. |
| format | Article |
| id | doaj-art-2cab6eae8ec8439cb9ed1c5794ab12a2 |
| institution | DOAJ |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-2cab6eae8ec8439cb9ed1c5794ab12a22025-08-20T03:10:52ZengNature PortfolioNature Communications2041-17232025-02-0116111710.1038/s41467-025-57016-0Bio-inspired electronics: Soft, biohybrid, and “living” neural interfacesDimitris Boufidis0Raghav Garg1Eugenia Angelopoulos2D. Kacy Cullen3Flavia Vitale4Department of Bioengineering, University of PennsylvaniaCenter for Neuroengineering and Therapeutics, University of PennsylvaniaCenter for Neuroengineering and Therapeutics, University of PennsylvaniaDepartment of Bioengineering, University of PennsylvaniaDepartment of Bioengineering, University of PennsylvaniaAbstract Neural interface technologies are increasingly evolving towards bio-inspired approaches to enhance integration and long-term functionality. Recent strategies merge soft materials with tissue engineering to realize biologically-active and/or cell-containing living layers at the tissue-device interface that enable seamless biointegration and novel cell-mediated therapeutic opportunities. This review maps the field of bio-inspired electronics and discusses key recent developments in tissue-like and regenerative bioelectronics, from soft biomaterials and surface-functionalized bioactive coatings to cell-containing ‘biohybrid’ and ‘all-living’ interfaces. We define and contextualize key terminology in this emerging field and highlight how biological and living components can bridge the gap to clinical translation.https://doi.org/10.1038/s41467-025-57016-0 |
| spellingShingle | Dimitris Boufidis Raghav Garg Eugenia Angelopoulos D. Kacy Cullen Flavia Vitale Bio-inspired electronics: Soft, biohybrid, and “living” neural interfaces Nature Communications |
| title | Bio-inspired electronics: Soft, biohybrid, and “living” neural interfaces |
| title_full | Bio-inspired electronics: Soft, biohybrid, and “living” neural interfaces |
| title_fullStr | Bio-inspired electronics: Soft, biohybrid, and “living” neural interfaces |
| title_full_unstemmed | Bio-inspired electronics: Soft, biohybrid, and “living” neural interfaces |
| title_short | Bio-inspired electronics: Soft, biohybrid, and “living” neural interfaces |
| title_sort | bio inspired electronics soft biohybrid and living neural interfaces |
| url | https://doi.org/10.1038/s41467-025-57016-0 |
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