Short-term outcomes of transcatheter perimembranous ventricular septal defect closure using the konar-multifunctional occluder: the Taiwanese experience
IntroductionTranscatheter device closure of perimembranous ventricular septal defect (PmVSD) using the Lifetech KONAR-MF ventricular septal defect occluder (MFO) presents a promising and effective alternative to surgical repair.ObjectivesThis study aims to evaluate the 6-month safety and efficacy of...
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| author | Li-Chin Liao Li-Chin Liao Li-Chin Liao Li-Chin Liao Li-Chin Liao Yun-Ching Fu Yun-Ching Fu Yun-Ching Fu Pi-Chang Lee Sheng-Ling Jan Ming-Chih Lin Ming-Chih Lin Chieh-Mao Chuang Hui-Chih Hung Hui-Chih Hung Hui-Chih Hung Hui-Chih Hung |
| author_facet | Li-Chin Liao Li-Chin Liao Li-Chin Liao Li-Chin Liao Li-Chin Liao Yun-Ching Fu Yun-Ching Fu Yun-Ching Fu Pi-Chang Lee Sheng-Ling Jan Ming-Chih Lin Ming-Chih Lin Chieh-Mao Chuang Hui-Chih Hung Hui-Chih Hung Hui-Chih Hung Hui-Chih Hung |
| author_sort | Li-Chin Liao |
| collection | DOAJ |
| description | IntroductionTranscatheter device closure of perimembranous ventricular septal defect (PmVSD) using the Lifetech KONAR-MF ventricular septal defect occluder (MFO) presents a promising and effective alternative to surgical repair.ObjectivesThis study aims to evaluate the 6-month safety and efficacy of the MFO device for PmVSD closure.Materials and methodsWe conducted a retrospective analysis of clinical data from patients who underwent percutaneous PmVSD closure using the MFO device at our institution between December 2021 and June 2024. Safety, procedural and 6-month outcomes were systematically assessed.ResultsA total of 115 patients (52.2% male) underwent transcatheter PmVSD closure. The median age was 7.6 years [interquartile range (IQR), 4.0–27.2] and weight 25.6 kg (IQR, 14.2–62.6). Median defect size by angiography was 5.7 mm (IQR, 3.8–8.3) on the left ventricle side and 3.3 mm (IQR, 2.3–4.4) on the right ventricle side. Aortic valve prolapse (AVP) was noted in 114 patients (99.1%), with pre-procedural aortic regurgitation (AR) in 36 (31.3%). Median pulmonary artery pressure was 17 mmHg (IQR, 14–20); 48 (41.7%) had Qp/Qs >1.5. All procedures were successful; 33 (28.7%) used a retrograde approach. Median fluoroscopy time was 22 min (IQR, 15–33). Complete closure was achieved in 51.3% at 1 day, 62.6% at 1 month, 69.6% at 3 months, and 83.5% at 6 months. Transient conduction disturbances (n = 4), hypotension (n = 1), and femoral hematoma (n = 1) were observed. No cases of endocarditis, valve injury, or complete atrioventricular block occurred.ConclusionTranscatheter closure of PmVSD with the MFO demonstrated safety and efficacy during the 6-month follow-up period. Notably, the majority of defects in this cohort were small in size. |
| format | Article |
| id | doaj-art-2ca9ecc81319490ca6b893f0ac64efbd |
| institution | Kabale University |
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| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-2ca9ecc81319490ca6b893f0ac64efbd2025-08-20T03:48:27ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2025-05-011210.3389/fcvm.2025.15728121572812Short-term outcomes of transcatheter perimembranous ventricular septal defect closure using the konar-multifunctional occluder: the Taiwanese experienceLi-Chin Liao0Li-Chin Liao1Li-Chin Liao2Li-Chin Liao3Li-Chin Liao4Yun-Ching Fu5Yun-Ching Fu6Yun-Ching Fu7Pi-Chang Lee8Sheng-Ling Jan9Ming-Chih Lin10Ming-Chih Lin11Chieh-Mao Chuang12Hui-Chih Hung13Hui-Chih Hung14Hui-Chih Hung15Hui-Chih Hung16Doctoral Program in Translational Medicine, National Chung Hsing University, Taichung, TaiwanRong Hsing Translational Medicine Research Center, National Chung Hsing University, Taichung, TaiwanDepartment of Pediatrics, Wuri Lin Shin Hospital, Taichung, TaiwanDepartment of Pediatric Cardiology, Children’s Medical Center, Taichung Veterans General Hospital, Taichung, TaiwanDepartment of Pediatrics, School of Medicine, National Chung Hsing University, Taichung, TaiwanDepartment of Pediatric Cardiology, Children’s Medical Center, Taichung Veterans General Hospital, Taichung, TaiwanDepartment of Pediatrics, School of Medicine, National Chung Hsing University, Taichung, TaiwanDepartment of Pediatrics and Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, TaiwanDepartment of Pediatric Cardiology, Children’s Medical Center, Taichung Veterans General Hospital, Taichung, TaiwanDepartment of Pediatric Cardiology, Children’s Medical Center, Taichung Veterans General Hospital, Taichung, TaiwanDepartment of Pediatric Cardiology, Children’s Medical Center, Taichung Veterans General Hospital, Taichung, TaiwanDepartment of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, TaiwanDepartment of Pediatric Cardiology, Children’s Medical Center, Taichung Veterans General Hospital, Taichung, TaiwanDoctoral Program in Translational Medicine, National Chung Hsing University, Taichung, TaiwanRong Hsing Translational Medicine Research Center, National Chung Hsing University, Taichung, TaiwanDepartment of Life Sciences, National Chung Hsing University, Taichung, TaiwaniEGG & Animal Biotechnology Center, National Chung Hsing University, Taichung, TaiwanIntroductionTranscatheter device closure of perimembranous ventricular septal defect (PmVSD) using the Lifetech KONAR-MF ventricular septal defect occluder (MFO) presents a promising and effective alternative to surgical repair.ObjectivesThis study aims to evaluate the 6-month safety and efficacy of the MFO device for PmVSD closure.Materials and methodsWe conducted a retrospective analysis of clinical data from patients who underwent percutaneous PmVSD closure using the MFO device at our institution between December 2021 and June 2024. Safety, procedural and 6-month outcomes were systematically assessed.ResultsA total of 115 patients (52.2% male) underwent transcatheter PmVSD closure. The median age was 7.6 years [interquartile range (IQR), 4.0–27.2] and weight 25.6 kg (IQR, 14.2–62.6). Median defect size by angiography was 5.7 mm (IQR, 3.8–8.3) on the left ventricle side and 3.3 mm (IQR, 2.3–4.4) on the right ventricle side. Aortic valve prolapse (AVP) was noted in 114 patients (99.1%), with pre-procedural aortic regurgitation (AR) in 36 (31.3%). Median pulmonary artery pressure was 17 mmHg (IQR, 14–20); 48 (41.7%) had Qp/Qs >1.5. All procedures were successful; 33 (28.7%) used a retrograde approach. Median fluoroscopy time was 22 min (IQR, 15–33). Complete closure was achieved in 51.3% at 1 day, 62.6% at 1 month, 69.6% at 3 months, and 83.5% at 6 months. Transient conduction disturbances (n = 4), hypotension (n = 1), and femoral hematoma (n = 1) were observed. No cases of endocarditis, valve injury, or complete atrioventricular block occurred.ConclusionTranscatheter closure of PmVSD with the MFO demonstrated safety and efficacy during the 6-month follow-up period. Notably, the majority of defects in this cohort were small in size.https://www.frontiersin.org/articles/10.3389/fcvm.2025.1572812/fullventricular septal defectoccludertranscatheter closureKONAR-MF occludercongenital heart defect |
| spellingShingle | Li-Chin Liao Li-Chin Liao Li-Chin Liao Li-Chin Liao Li-Chin Liao Yun-Ching Fu Yun-Ching Fu Yun-Ching Fu Pi-Chang Lee Sheng-Ling Jan Ming-Chih Lin Ming-Chih Lin Chieh-Mao Chuang Hui-Chih Hung Hui-Chih Hung Hui-Chih Hung Hui-Chih Hung Short-term outcomes of transcatheter perimembranous ventricular septal defect closure using the konar-multifunctional occluder: the Taiwanese experience Frontiers in Cardiovascular Medicine ventricular septal defect occluder transcatheter closure KONAR-MF occluder congenital heart defect |
| title | Short-term outcomes of transcatheter perimembranous ventricular septal defect closure using the konar-multifunctional occluder: the Taiwanese experience |
| title_full | Short-term outcomes of transcatheter perimembranous ventricular septal defect closure using the konar-multifunctional occluder: the Taiwanese experience |
| title_fullStr | Short-term outcomes of transcatheter perimembranous ventricular septal defect closure using the konar-multifunctional occluder: the Taiwanese experience |
| title_full_unstemmed | Short-term outcomes of transcatheter perimembranous ventricular septal defect closure using the konar-multifunctional occluder: the Taiwanese experience |
| title_short | Short-term outcomes of transcatheter perimembranous ventricular septal defect closure using the konar-multifunctional occluder: the Taiwanese experience |
| title_sort | short term outcomes of transcatheter perimembranous ventricular septal defect closure using the konar multifunctional occluder the taiwanese experience |
| topic | ventricular septal defect occluder transcatheter closure KONAR-MF occluder congenital heart defect |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1572812/full |
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