The HIF-1α/PKM2 Feedback Loop in Relation to EGFR Mutational Status in Lung Adenocarcinoma

The HIF-1α/PKM2 Feedback Loop in Relation to EGFR Mutational Status in Lung Adenocarcinoma

Objective Gene mutations in tumor cells can lead to several unique metabolic phenotypes, which are crucial for the proliferation of cancer cells. EGFR mutation (EGFR-mt) is the main oncogenic driving mutation in lung adenocarcinoma (LUAD). HIF-1 α and PKM2 are two key metabolic regulatory proteins t...

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Bibliographic Details
Main Authors: Yuan Wang, Hongguang Lian, Jiajun Li, Man Zhao, Zengfang Hao, Xue Zheng, Linyuan Zhao, Jinfeng Cui
Format: Article
Language:English
Published: Taylor & Francis Group 2024-01-01
Series:Journal of Investigative Surgery
Subjects:
lung adenocarcinoma
glycolysis
HIF-1α
PKM2
EGFR
Online Access:https://www.tandfonline.com/doi/10.1080/08941939.2023.2301081
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