Re-emergence of vaccine-derived polio in the demographic Republic of Congo: Causes and consequences
Poliovirus is a deadly disease that needs to be eradicated in the world. Recently, issues with circulating vaccine-derived polioviruses (cVDPVs) in the Democratic Republic of the Congo (DRC) have been raised in the country. This article aims to determine the increase in Type 1 cVDPV1 and Type 2 cVDP...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | New Microbes and New Infections |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2052297524002737 |
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| author | Malik Olatunde Oduoye Samuel Chinonso Ubechu Marina Ramzy Mourid Ahmad Ibrahim Ahmad Abdullahi Adeyemi Adegoke Umulkhairah Onyioiza Arama Muhammad Furqan Saiyad Ali Bashiru Muhammad Auwal F.N.U. Fariha Ankini Mukherjee Aymar Akilimali |
| author_facet | Malik Olatunde Oduoye Samuel Chinonso Ubechu Marina Ramzy Mourid Ahmad Ibrahim Ahmad Abdullahi Adeyemi Adegoke Umulkhairah Onyioiza Arama Muhammad Furqan Saiyad Ali Bashiru Muhammad Auwal F.N.U. Fariha Ankini Mukherjee Aymar Akilimali |
| author_sort | Malik Olatunde Oduoye |
| collection | DOAJ |
| description | Poliovirus is a deadly disease that needs to be eradicated in the world. Recently, issues with circulating vaccine-derived polioviruses (cVDPVs) in the Democratic Republic of the Congo (DRC) have been raised in the country. This article aims to determine the increase in Type 1 cVDPV1 and Type 2 cVDPV2 in the DRC. Relevant articles on PubMed, Google Scholar, ResearchGate, and Web of Science were searched from 2010 to 2023. Our findings indicate that the Democratic Republic of Congo has struggled with polio outbreaks, with the virus primarily linked to cVDPVs produced from vaccines rather than wild poliovirus. These cVDPVs have the potential to revert to their paralyzing capabilities by evolving from the weakened virus seen in the oral polio vaccination (OPV). Several regions in DRC have reported cVDPV outbreaks of cVDPVs. Numerous cVDPV2 outbreaks were documented in various provinces during the 2017–2018 period. Addressing the cVDPV outbreak in the DRC requires a concerted global effort, involving collaboration among governments, international health organizations, and donor agencies. There should be global support and collaboration among governments, international health organizations, and donor agencies to address the cVDPV outbreak in the DRC. |
| format | Article |
| id | doaj-art-2ca3840b25a54ef797e618fea5688e1a |
| institution | DOAJ |
| issn | 2052-2975 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | New Microbes and New Infections |
| spelling | doaj-art-2ca3840b25a54ef797e618fea5688e1a2025-08-20T02:49:49ZengElsevierNew Microbes and New Infections2052-29752024-12-016210148910.1016/j.nmni.2024.101489Re-emergence of vaccine-derived polio in the demographic Republic of Congo: Causes and consequencesMalik Olatunde Oduoye0Samuel Chinonso Ubechu1Marina Ramzy Mourid2Ahmad Ibrahim Ahmad3Abdullahi Adeyemi Adegoke4Umulkhairah Onyioiza Arama5Muhammad Furqan6Saiyad Ali7Bashiru Muhammad Auwal8F.N.U. Fariha9Ankini Mukherjee10Aymar Akilimali11Department of Research, The Medical Research Circle (MedReC), Goma, Democratic Republic of the Congo; Corresponding author. Department of Research, The Medical Research Circle (MedReC), Goma, Democratic Republic of the Congo.University of Nigeria (UNN), Enugu State, Nigeria; Yale University, New Haven, CT, USAFaculty of Medicine, Alexandria University, Alexandria, EgyptMaryam Abacha American University of Niger, Maradi, Niger RepublicDepartment of Pharmacognosy, University of Ibadan, Ibadan, Oyo state, NigeriaAhmadu Bello University, Zaria, Kaduna State, NigeriaDepartment of Medicine, King Edward Medical University, Lahore, PakistanSaidu Medical College, PakistanCollege of Medicine and Allied Health Sciences, Federal University Dutse, Jigawa state, NigeriaDow University of Health Sciences, PakistanRampurhat Government Medical College, West Bengal, IndiaDepartment of Research, The Medical Research Circle (MedReC), Goma, Democratic Republic of the CongoPoliovirus is a deadly disease that needs to be eradicated in the world. Recently, issues with circulating vaccine-derived polioviruses (cVDPVs) in the Democratic Republic of the Congo (DRC) have been raised in the country. This article aims to determine the increase in Type 1 cVDPV1 and Type 2 cVDPV2 in the DRC. Relevant articles on PubMed, Google Scholar, ResearchGate, and Web of Science were searched from 2010 to 2023. Our findings indicate that the Democratic Republic of Congo has struggled with polio outbreaks, with the virus primarily linked to cVDPVs produced from vaccines rather than wild poliovirus. These cVDPVs have the potential to revert to their paralyzing capabilities by evolving from the weakened virus seen in the oral polio vaccination (OPV). Several regions in DRC have reported cVDPV outbreaks of cVDPVs. Numerous cVDPV2 outbreaks were documented in various provinces during the 2017–2018 period. Addressing the cVDPV outbreak in the DRC requires a concerted global effort, involving collaboration among governments, international health organizations, and donor agencies. There should be global support and collaboration among governments, international health organizations, and donor agencies to address the cVDPV outbreak in the DRC.http://www.sciencedirect.com/science/article/pii/S2052297524002737Circulating vaccine-derived poliovirusDemocratic Republic of CongoRealitiesHealth impactStrategiesMitigation |
| spellingShingle | Malik Olatunde Oduoye Samuel Chinonso Ubechu Marina Ramzy Mourid Ahmad Ibrahim Ahmad Abdullahi Adeyemi Adegoke Umulkhairah Onyioiza Arama Muhammad Furqan Saiyad Ali Bashiru Muhammad Auwal F.N.U. Fariha Ankini Mukherjee Aymar Akilimali Re-emergence of vaccine-derived polio in the demographic Republic of Congo: Causes and consequences New Microbes and New Infections Circulating vaccine-derived poliovirus Democratic Republic of Congo Realities Health impact Strategies Mitigation |
| title | Re-emergence of vaccine-derived polio in the demographic Republic of Congo: Causes and consequences |
| title_full | Re-emergence of vaccine-derived polio in the demographic Republic of Congo: Causes and consequences |
| title_fullStr | Re-emergence of vaccine-derived polio in the demographic Republic of Congo: Causes and consequences |
| title_full_unstemmed | Re-emergence of vaccine-derived polio in the demographic Republic of Congo: Causes and consequences |
| title_short | Re-emergence of vaccine-derived polio in the demographic Republic of Congo: Causes and consequences |
| title_sort | re emergence of vaccine derived polio in the demographic republic of congo causes and consequences |
| topic | Circulating vaccine-derived poliovirus Democratic Republic of Congo Realities Health impact Strategies Mitigation |
| url | http://www.sciencedirect.com/science/article/pii/S2052297524002737 |
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