Evaluation of Health Associations With Height‐Normalised Abdominal Body Composition Indices: A Single‐Centre Cross‐Sectional Study
ABSTRACT Background Traditional metrics such as body mass index (BMI) and waist circumference (WC) fail to accurately assess the health outcomes associated with abdominal adiposity, because they neglect the intricacies of adipose tissue distribution. Notably, the variability in body composition scal...
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| Format: | Article |
| Language: | English |
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Wiley
2024-12-01
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| Series: | Journal of Cachexia, Sarcopenia and Muscle |
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| Online Access: | https://doi.org/10.1002/jcsm.13609 |
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| author | Yupeng Liu Hangqian He Keyu Qian Yufeng Huang Xuemei Ao Xudong Shi Binye Ruan Ru Xue Xiaoyi Fu Shuran Wang |
| author_facet | Yupeng Liu Hangqian He Keyu Qian Yufeng Huang Xuemei Ao Xudong Shi Binye Ruan Ru Xue Xiaoyi Fu Shuran Wang |
| author_sort | Yupeng Liu |
| collection | DOAJ |
| description | ABSTRACT Background Traditional metrics such as body mass index (BMI) and waist circumference (WC) fail to accurately assess the health outcomes associated with abdominal adiposity, because they neglect the intricacies of adipose tissue distribution. Notably, the variability in body composition scaled to height remains underexplored in Chinese demographics. This study introduces height‐normalised indices of abdominal adiposity using computed tomography (CT) scans and further assesses their associations with various health outcomes. Methods In a large, diverse Chinese population (n = 1054 healthy individuals; n = 1159 with dyslipidemia; n = 803 with diabetes; n = 1289 with cardio‐cerebrovascular diseases; n = 1108 with cancers; and n = 509 with abnormal bone mas), abdominal CT scans were performed and allometric growth model analyses were used to derive height‐normalised indices (body composition/heightβ). Logistic regression models assessed the associations between these indices and health outcomes. Results Distinct scaling powers were observed for visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT) and total abdominal adipose tissue (TAT), as well as for sagittal diameter (SAD), with marked sex differences. Powers for VAT were 1.786 ± 1.270 for males and 1.274 ± 0.692 for females. Powers for SAT were 2.266 ± 0.856 for males and 1.656 ± 0.497 for females. Powers for TAT were 2.141 ± 0.967 for males and 1.438 ± 0.489 for females. Powers for SAD were 0.646 ± 0.217 for males and 0.678 ± 0.141 for females. After controlling for age, BMI and WC, VAT/heightβ, TAT/heightβ and SAD/heightβ retained their significantly positive associations with the odds of health outcomes, whereas SAT/heightβ did not. Conclusions Our findings endorse the clinical utility of height‐normalised indices, particularly VAT/heightβ, TAT/heightβ and SAD/heightβ, in health outcomes assessment. These indices, grounded in robust empirical data, underscore the necessity of a nuanced approach in obesity‐related health evaluations, advocating for a departure from conventional methods like BMI. |
| format | Article |
| id | doaj-art-2ca344a809ae4bc4a7adf7124fa3dc48 |
| institution | OA Journals |
| issn | 2190-5991 2190-6009 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wiley |
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| series | Journal of Cachexia, Sarcopenia and Muscle |
| spelling | doaj-art-2ca344a809ae4bc4a7adf7124fa3dc482025-08-20T01:58:56ZengWileyJournal of Cachexia, Sarcopenia and Muscle2190-59912190-60092024-12-011562651265910.1002/jcsm.13609Evaluation of Health Associations With Height‐Normalised Abdominal Body Composition Indices: A Single‐Centre Cross‐Sectional StudyYupeng Liu0Hangqian He1Keyu Qian2Yufeng Huang3Xuemei Ao4Xudong Shi5Binye Ruan6Ru Xue7Xiaoyi Fu8Shuran Wang9Department of Preventive Medicine, School of Public Health and Management Wenzhou Medical University Wenzhou ChinaDepartment of Preventive Medicine, School of Public Health and Management Wenzhou Medical University Wenzhou ChinaDepartment of Preventive Medicine, School of Public Health and Management Wenzhou Medical University Wenzhou ChinaDepartment of Preventive Medicine, School of Public Health and Management Wenzhou Medical University Wenzhou ChinaDepartment of Preventive Medicine, School of Public Health and Management Wenzhou Medical University Wenzhou ChinaDepartment of Preventive Medicine, School of Public Health and Management Wenzhou Medical University Wenzhou ChinaDepartment of Preventive Medicine, School of Public Health and Management Wenzhou Medical University Wenzhou ChinaDepartment of Preventive Medicine, School of Public Health and Management Wenzhou Medical University Wenzhou ChinaDepartment of Preventive Medicine, School of Public Health and Management Wenzhou Medical University Wenzhou ChinaDepartment of Preventive Medicine, School of Public Health and Management Wenzhou Medical University Wenzhou ChinaABSTRACT Background Traditional metrics such as body mass index (BMI) and waist circumference (WC) fail to accurately assess the health outcomes associated with abdominal adiposity, because they neglect the intricacies of adipose tissue distribution. Notably, the variability in body composition scaled to height remains underexplored in Chinese demographics. This study introduces height‐normalised indices of abdominal adiposity using computed tomography (CT) scans and further assesses their associations with various health outcomes. Methods In a large, diverse Chinese population (n = 1054 healthy individuals; n = 1159 with dyslipidemia; n = 803 with diabetes; n = 1289 with cardio‐cerebrovascular diseases; n = 1108 with cancers; and n = 509 with abnormal bone mas), abdominal CT scans were performed and allometric growth model analyses were used to derive height‐normalised indices (body composition/heightβ). Logistic regression models assessed the associations between these indices and health outcomes. Results Distinct scaling powers were observed for visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT) and total abdominal adipose tissue (TAT), as well as for sagittal diameter (SAD), with marked sex differences. Powers for VAT were 1.786 ± 1.270 for males and 1.274 ± 0.692 for females. Powers for SAT were 2.266 ± 0.856 for males and 1.656 ± 0.497 for females. Powers for TAT were 2.141 ± 0.967 for males and 1.438 ± 0.489 for females. Powers for SAD were 0.646 ± 0.217 for males and 0.678 ± 0.141 for females. After controlling for age, BMI and WC, VAT/heightβ, TAT/heightβ and SAD/heightβ retained their significantly positive associations with the odds of health outcomes, whereas SAT/heightβ did not. Conclusions Our findings endorse the clinical utility of height‐normalised indices, particularly VAT/heightβ, TAT/heightβ and SAD/heightβ, in health outcomes assessment. These indices, grounded in robust empirical data, underscore the necessity of a nuanced approach in obesity‐related health evaluations, advocating for a departure from conventional methods like BMI.https://doi.org/10.1002/jcsm.13609adipose tissueallometric analysishealth outcomesheightscaling powers |
| spellingShingle | Yupeng Liu Hangqian He Keyu Qian Yufeng Huang Xuemei Ao Xudong Shi Binye Ruan Ru Xue Xiaoyi Fu Shuran Wang Evaluation of Health Associations With Height‐Normalised Abdominal Body Composition Indices: A Single‐Centre Cross‐Sectional Study Journal of Cachexia, Sarcopenia and Muscle adipose tissue allometric analysis health outcomes height scaling powers |
| title | Evaluation of Health Associations With Height‐Normalised Abdominal Body Composition Indices: A Single‐Centre Cross‐Sectional Study |
| title_full | Evaluation of Health Associations With Height‐Normalised Abdominal Body Composition Indices: A Single‐Centre Cross‐Sectional Study |
| title_fullStr | Evaluation of Health Associations With Height‐Normalised Abdominal Body Composition Indices: A Single‐Centre Cross‐Sectional Study |
| title_full_unstemmed | Evaluation of Health Associations With Height‐Normalised Abdominal Body Composition Indices: A Single‐Centre Cross‐Sectional Study |
| title_short | Evaluation of Health Associations With Height‐Normalised Abdominal Body Composition Indices: A Single‐Centre Cross‐Sectional Study |
| title_sort | evaluation of health associations with height normalised abdominal body composition indices a single centre cross sectional study |
| topic | adipose tissue allometric analysis health outcomes height scaling powers |
| url | https://doi.org/10.1002/jcsm.13609 |
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