Nasal septum extramedullary plasmacytoma
Introduction. Plasmacytomas are malignant tumors characterized by abnormal monoclonal proliferation of plasma cells. They originate in either bone - solitary osseous plasmacytoma, or in soft tissue - extramedullary plasmacytoma (EMP). EMP represents less than 1% of all head and neck mali...
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Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2013-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2013/0042-84501302221B.pdf |
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| author | Belić Branislav Mitrović Slobodanka Arsenijević Snežana Erdevički Ljiljana Stojanović Jasmina Stojanović Stevan Stolić Radojica |
| author_facet | Belić Branislav Mitrović Slobodanka Arsenijević Snežana Erdevički Ljiljana Stojanović Jasmina Stojanović Stevan Stolić Radojica |
| author_sort | Belić Branislav |
| collection | DOAJ |
| description | Introduction. Plasmacytomas are malignant tumors characterized by abnormal
monoclonal proliferation of plasma cells. They originate in either bone -
solitary osseous plasmacytoma, or in soft tissue - extramedullary
plasmacytoma (EMP). EMP represents less than 1% of all head and neck
malignancies. Case report. We presented a case of EMP of the nasal septum in
a 44-year-old male who had progressive difficulty in breathing through the
nose and frequent heavy epistaxis on the right side. Nasal endoscopy showed
dark red, soft, polypoid tumor in the last third of the right nasal cavity
arising from the nasal septum. The biopsy showed that it was plasmacytoma.
Bence Jones protein in the urine, serum electrophoresis, bone marrow biopsy,
skeletal survey and other screening tests failed to detect multiple myeloma.
This confirmed the diagnosis of EMP. The mass was completely removed via an
endoscopic approach, and then, 4 week later, radiotherapy was conducted with
a radiation dose of 50 Gray. No recurrence was noted in a 3-year follow- up
period. Conclusion. EMP of the nasal cavity, being rare and having long
natural history, represents a diagnostic and therapeutic challenge for any
ear, nose and throat surgeon. Depending on the resectability of the lesion, a
combined therapy is the accepted treatment. |
| format | Article |
| id | doaj-art-2c9f5cce7a4b43f7b1a97157be53c64e |
| institution | OA Journals |
| issn | 0042-8450 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-2c9f5cce7a4b43f7b1a97157be53c64e2025-08-20T02:01:34ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502013-01-0170222122410.2298/VSP1302221B0042-84501302221BNasal septum extramedullary plasmacytomaBelić Branislav0Mitrović Slobodanka1Arsenijević Snežana2Erdevički Ljiljana3Stojanović Jasmina4Stojanović Stevan5Stolić Radojica6Faculty of Medicine, Kosovska MitrovicaClinical Center Kragujevac, Department of Histopathology, KragujevacFaculty of Medical Sciences, KragujevacFaculty of Medical Sciences, KragujevacClinical Center Kragujevac, Ear, Nose and Throat Clinic, KragujevacFaculty of Medical Sciences, KragujevacFaculty of Medicine, Kosovska MitrovicaIntroduction. Plasmacytomas are malignant tumors characterized by abnormal monoclonal proliferation of plasma cells. They originate in either bone - solitary osseous plasmacytoma, or in soft tissue - extramedullary plasmacytoma (EMP). EMP represents less than 1% of all head and neck malignancies. Case report. We presented a case of EMP of the nasal septum in a 44-year-old male who had progressive difficulty in breathing through the nose and frequent heavy epistaxis on the right side. Nasal endoscopy showed dark red, soft, polypoid tumor in the last third of the right nasal cavity arising from the nasal septum. The biopsy showed that it was plasmacytoma. Bence Jones protein in the urine, serum electrophoresis, bone marrow biopsy, skeletal survey and other screening tests failed to detect multiple myeloma. This confirmed the diagnosis of EMP. The mass was completely removed via an endoscopic approach, and then, 4 week later, radiotherapy was conducted with a radiation dose of 50 Gray. No recurrence was noted in a 3-year follow- up period. Conclusion. EMP of the nasal cavity, being rare and having long natural history, represents a diagnostic and therapeutic challenge for any ear, nose and throat surgeon. Depending on the resectability of the lesion, a combined therapy is the accepted treatment.http://www.doiserbia.nb.rs/img/doi/0042-8450/2013/0042-84501302221B.pdfplasmacytomanasal septumdiagnosisdiagnosis, differentialotorhinolaryngological surgical proceduresradiotherapytreatment outcome |
| spellingShingle | Belić Branislav Mitrović Slobodanka Arsenijević Snežana Erdevički Ljiljana Stojanović Jasmina Stojanović Stevan Stolić Radojica Nasal septum extramedullary plasmacytoma Vojnosanitetski Pregled plasmacytoma nasal septum diagnosis diagnosis, differential otorhinolaryngological surgical procedures radiotherapy treatment outcome |
| title | Nasal septum extramedullary plasmacytoma |
| title_full | Nasal septum extramedullary plasmacytoma |
| title_fullStr | Nasal septum extramedullary plasmacytoma |
| title_full_unstemmed | Nasal septum extramedullary plasmacytoma |
| title_short | Nasal septum extramedullary plasmacytoma |
| title_sort | nasal septum extramedullary plasmacytoma |
| topic | plasmacytoma nasal septum diagnosis diagnosis, differential otorhinolaryngological surgical procedures radiotherapy treatment outcome |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2013/0042-84501302221B.pdf |
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