Nasal septum extramedullary plasmacytoma
Introduction. Plasmacytomas are malignant tumors characterized by abnormal monoclonal proliferation of plasma cells. They originate in either bone - solitary osseous plasmacytoma, or in soft tissue - extramedullary plasmacytoma (EMP). EMP represents less than 1% of all head and neck mali...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2013-01-01
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| Series: | Vojnosanitetski Pregled |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2013/0042-84501302221B.pdf |
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| Summary: | Introduction. Plasmacytomas are malignant tumors characterized by abnormal
monoclonal proliferation of plasma cells. They originate in either bone -
solitary osseous plasmacytoma, or in soft tissue - extramedullary
plasmacytoma (EMP). EMP represents less than 1% of all head and neck
malignancies. Case report. We presented a case of EMP of the nasal septum in
a 44-year-old male who had progressive difficulty in breathing through the
nose and frequent heavy epistaxis on the right side. Nasal endoscopy showed
dark red, soft, polypoid tumor in the last third of the right nasal cavity
arising from the nasal septum. The biopsy showed that it was plasmacytoma.
Bence Jones protein in the urine, serum electrophoresis, bone marrow biopsy,
skeletal survey and other screening tests failed to detect multiple myeloma.
This confirmed the diagnosis of EMP. The mass was completely removed via an
endoscopic approach, and then, 4 week later, radiotherapy was conducted with
a radiation dose of 50 Gray. No recurrence was noted in a 3-year follow- up
period. Conclusion. EMP of the nasal cavity, being rare and having long
natural history, represents a diagnostic and therapeutic challenge for any
ear, nose and throat surgeon. Depending on the resectability of the lesion, a
combined therapy is the accepted treatment. |
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| ISSN: | 0042-8450 |