The evaluation of epicardial adipose tissue and carotid intima-media thickness in patients with Behçet’s disease
Background/Aim. Epidemiological studies indicate that cardiovascular disease (CVD) is common in almost all patients diagnosed with autoimmune disease. This study aimed to examine whether epicardial adipose tissue (EAT) thickness (EATT) and carotid intima-media (CIM) thickness (CIMT) differ between p...
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Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2022-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2022/0042-84502100095S.pdf |
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| author | Sağlam Gonca Turgut Mehmet Cenk Gülcü Oktay |
| author_facet | Sağlam Gonca Turgut Mehmet Cenk Gülcü Oktay |
| author_sort | Sağlam Gonca |
| collection | DOAJ |
| description | Background/Aim. Epidemiological studies indicate that cardiovascular disease (CVD) is common in almost all patients diagnosed with autoimmune disease. This study aimed to examine whether epicardial adipose tissue (EAT) thickness (EATT) and carotid intima-media (CIM) thickness (CIMT) differ between patients with Behçet’s disease (BD) and healthy individuals. Methods. A total of 40 healthy subjects as controls and 40 BD patients with musculoskeletal complaints were enrolled in this cross-sectional prospective study. Socio-demographic, clinical, and laboratory data were obtained and compared between groups. The Behçet’s Disease Current Activity Form was used to assess disease activity. Both groups underwent echocardiography in order to measure EATT and CIMT. Results. The mean thickness of EAT (5.70 ± 1.05 mm; 2.50 ± 0.61 mm, respectively, p < 0.001) and CIM (0.68 ± 0.05 mm; 0.63 ± 0.06 mm, respectively, p = 0.002) were significantly in-creased in BD patients compared to the control group. A positive correlation was observed between EATT and age (r = 0.500, p = 0.001), the duration of the disease (r = 0.330, p < 0.001), waist circumference (r = 0.316, p = 0.013), and disease activity (r = 0.31, p < 0.001) in the patient group. CIMT was positively correlated with age (r = 0.594, p = 0.001) and the duration of the disease (r = 0.585, p = 0.001). The use of glucocorticoids or clinical manifestations (joint involvements, genital ulcer, skin lesions, inflammatory back pain, and major organ involvement) of the patients were not found to be associated with EATT or CIMT. Conclusion. EATT and CIMT are in-creased in patients with BD and are associated with dis-ease activity. Echocardiographic measurement of EATT and CIMT is an objective, noninvasive, and available method that can evaluate the risk of subclinical atherosclerosis in patients with BD. |
| format | Article |
| id | doaj-art-2c9e9fac5cb145e8b6a55d813b124e98 |
| institution | Kabale University |
| issn | 0042-8450 2406-0720 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-2c9e9fac5cb145e8b6a55d813b124e982025-08-20T03:55:00ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502406-07202022-01-01791096396910.2298/VSP200120095S0042-84502100095SThe evaluation of epicardial adipose tissue and carotid intima-media thickness in patients with Behçet’s diseaseSağlam Gonca0https://orcid.org/0000-0001-7713-4435Turgut Mehmet Cenk1https://orcid.org/0000-0002-8642-6824Gülcü Oktay2https://orcid.org/0000-0003-4479-2997Karadeniz Technical University, Faculty of Medicine, Department of Physical Medicine and Rehabilitation, Trabzon, TurkeyErzurum Training and Research Hospital, Department of Orthopedics and Traumatology, Erzurum, TurkeyErzurum Training and Research Hospital, Department of Cardiology, Erzurum, TurkeyBackground/Aim. Epidemiological studies indicate that cardiovascular disease (CVD) is common in almost all patients diagnosed with autoimmune disease. This study aimed to examine whether epicardial adipose tissue (EAT) thickness (EATT) and carotid intima-media (CIM) thickness (CIMT) differ between patients with Behçet’s disease (BD) and healthy individuals. Methods. A total of 40 healthy subjects as controls and 40 BD patients with musculoskeletal complaints were enrolled in this cross-sectional prospective study. Socio-demographic, clinical, and laboratory data were obtained and compared between groups. The Behçet’s Disease Current Activity Form was used to assess disease activity. Both groups underwent echocardiography in order to measure EATT and CIMT. Results. The mean thickness of EAT (5.70 ± 1.05 mm; 2.50 ± 0.61 mm, respectively, p < 0.001) and CIM (0.68 ± 0.05 mm; 0.63 ± 0.06 mm, respectively, p = 0.002) were significantly in-creased in BD patients compared to the control group. A positive correlation was observed between EATT and age (r = 0.500, p = 0.001), the duration of the disease (r = 0.330, p < 0.001), waist circumference (r = 0.316, p = 0.013), and disease activity (r = 0.31, p < 0.001) in the patient group. CIMT was positively correlated with age (r = 0.594, p = 0.001) and the duration of the disease (r = 0.585, p = 0.001). The use of glucocorticoids or clinical manifestations (joint involvements, genital ulcer, skin lesions, inflammatory back pain, and major organ involvement) of the patients were not found to be associated with EATT or CIMT. Conclusion. EATT and CIMT are in-creased in patients with BD and are associated with dis-ease activity. Echocardiographic measurement of EATT and CIMT is an objective, noninvasive, and available method that can evaluate the risk of subclinical atherosclerosis in patients with BD.http://www.doiserbia.nb.rs/img/doi/0042-8450/2022/0042-84502100095S.pdfadipose tissueatherosclerosisautoimmune diseasesbehcet syndromecarotid artery, commonpericardiumrisktunica intimatunica mediaultrasonography |
| spellingShingle | Sağlam Gonca Turgut Mehmet Cenk Gülcü Oktay The evaluation of epicardial adipose tissue and carotid intima-media thickness in patients with Behçet’s disease Vojnosanitetski Pregled adipose tissue atherosclerosis autoimmune diseases behcet syndrome carotid artery, common pericardium risk tunica intima tunica media ultrasonography |
| title | The evaluation of epicardial adipose tissue and carotid intima-media thickness in patients with Behçet’s disease |
| title_full | The evaluation of epicardial adipose tissue and carotid intima-media thickness in patients with Behçet’s disease |
| title_fullStr | The evaluation of epicardial adipose tissue and carotid intima-media thickness in patients with Behçet’s disease |
| title_full_unstemmed | The evaluation of epicardial adipose tissue and carotid intima-media thickness in patients with Behçet’s disease |
| title_short | The evaluation of epicardial adipose tissue and carotid intima-media thickness in patients with Behçet’s disease |
| title_sort | evaluation of epicardial adipose tissue and carotid intima media thickness in patients with behcet s disease |
| topic | adipose tissue atherosclerosis autoimmune diseases behcet syndrome carotid artery, common pericardium risk tunica intima tunica media ultrasonography |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2022/0042-84502100095S.pdf |
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