Gastric adenocarcinoma with enteroblastic differentiation in a 67-year-old man in Korea: a case report
We report a rare case of gastric adenocarcinoma with enteroblastic differentiation (GAED) that was treated with endoscopic submucosal dissection followed by additional distal gastrectomy with lymph node dissection. A 67-year-old man underwe...
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| Format: | Article |
| Language: | English |
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Ewha Womans University College of Medicine
2024-04-01
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| Series: | The Ewha Medical Journal |
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| Online Access: | http://www.e-emj.org/archive/view_article?pid=emj-47-2-28 |
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| author | Hae Rin Lee Gwang Ha Kim Dong Chan Joo Moon Won Lee Bong Eun Lee Kyung Bin Kim |
| author_facet | Hae Rin Lee Gwang Ha Kim Dong Chan Joo Moon Won Lee Bong Eun Lee Kyung Bin Kim |
| author_sort | Hae Rin Lee |
| collection | DOAJ |
| description | We report a rare case of gastric adenocarcinoma with enteroblastic
differentiation (GAED) that was treated with endoscopic submucosal dissection
followed by additional distal gastrectomy with lymph node dissection. A
67-year-old man underwent endoscopic submucosal dissection for a gastric lesion,
which was diagnosed as GAED with submucosal and lymphatic invasion.
Histologically, GAED is characterized by a tubulopapillary growth pattern and
clear cells that resemble those of the primitive fetal gut.
Immunohistochemically, GAED variably expresses oncofetal proteins such as
glypican-3, alpha-fetoprotein, and spalt-like transcription factor 4. Despite
negative margins, additional gastrectomy with lymph node dissection was
performed due to submucosal and lymphatic invasion. No residual tumor or
metastasis was detected, and the patient remained disease-free for 2 years
before dying from causes unrelated to GAED. Given its aggressive nature,
frequent lymphovascular invasion, and high metastatic potential, clinicians
should recognize the histopathological diagnosis of this rare tumor and its
propensity for aggressiveness. |
| format | Article |
| id | doaj-art-2c9727dc701b49609c9c5c5d6ffef548 |
| institution | OA Journals |
| issn | 2234-2591 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | Ewha Womans University College of Medicine |
| record_format | Article |
| series | The Ewha Medical Journal |
| spelling | doaj-art-2c9727dc701b49609c9c5c5d6ffef5482025-08-20T01:56:28ZengEwha Womans University College of MedicineThe Ewha Medical Journal2234-25912024-04-0147210.12771/emj.2024.e28emj-47-2-28Gastric adenocarcinoma with enteroblastic differentiation in a 67-year-old man in Korea: a case reportHae Rin LeeGwang Ha KimDong Chan JooMoon Won LeeBong Eun LeeKyung Bin KimWe report a rare case of gastric adenocarcinoma with enteroblastic differentiation (GAED) that was treated with endoscopic submucosal dissection followed by additional distal gastrectomy with lymph node dissection. A 67-year-old man underwent endoscopic submucosal dissection for a gastric lesion, which was diagnosed as GAED with submucosal and lymphatic invasion. Histologically, GAED is characterized by a tubulopapillary growth pattern and clear cells that resemble those of the primitive fetal gut. Immunohistochemically, GAED variably expresses oncofetal proteins such as glypican-3, alpha-fetoprotein, and spalt-like transcription factor 4. Despite negative margins, additional gastrectomy with lymph node dissection was performed due to submucosal and lymphatic invasion. No residual tumor or metastasis was detected, and the patient remained disease-free for 2 years before dying from causes unrelated to GAED. Given its aggressive nature, frequent lymphovascular invasion, and high metastatic potential, clinicians should recognize the histopathological diagnosis of this rare tumor and its propensity for aggressiveness.http://www.e-emj.org/archive/view_article?pid=emj-47-2-28adenocarcinomaalpha-fetoproteinsendoscopic mucosal resectiongastrectomytranscription factor 4 |
| spellingShingle | Hae Rin Lee Gwang Ha Kim Dong Chan Joo Moon Won Lee Bong Eun Lee Kyung Bin Kim Gastric adenocarcinoma with enteroblastic differentiation in a 67-year-old man in Korea: a case report The Ewha Medical Journal adenocarcinoma alpha-fetoproteins endoscopic mucosal resection gastrectomy transcription factor 4 |
| title | Gastric adenocarcinoma with enteroblastic differentiation in a
67-year-old man in Korea: a case report |
| title_full | Gastric adenocarcinoma with enteroblastic differentiation in a
67-year-old man in Korea: a case report |
| title_fullStr | Gastric adenocarcinoma with enteroblastic differentiation in a
67-year-old man in Korea: a case report |
| title_full_unstemmed | Gastric adenocarcinoma with enteroblastic differentiation in a
67-year-old man in Korea: a case report |
| title_short | Gastric adenocarcinoma with enteroblastic differentiation in a
67-year-old man in Korea: a case report |
| title_sort | gastric adenocarcinoma with enteroblastic differentiation in a 67 year old man in korea a case report |
| topic | adenocarcinoma alpha-fetoproteins endoscopic mucosal resection gastrectomy transcription factor 4 |
| url | http://www.e-emj.org/archive/view_article?pid=emj-47-2-28 |
| work_keys_str_mv | AT haerinlee gastricadenocarcinomawithenteroblasticdifferentiationina67yearoldmaninkoreaacasereport AT gwanghakim gastricadenocarcinomawithenteroblasticdifferentiationina67yearoldmaninkoreaacasereport AT dongchanjoo gastricadenocarcinomawithenteroblasticdifferentiationina67yearoldmaninkoreaacasereport AT moonwonlee gastricadenocarcinomawithenteroblasticdifferentiationina67yearoldmaninkoreaacasereport AT bongeunlee gastricadenocarcinomawithenteroblasticdifferentiationina67yearoldmaninkoreaacasereport AT kyungbinkim gastricadenocarcinomawithenteroblasticdifferentiationina67yearoldmaninkoreaacasereport |