Bmi‐1 Epigenetically Orchestrates Osteogenic and Adipogenic Differentiation of Bone Marrow Mesenchymal Stem Cells to Delay Bone Aging

Bmi‐1 Epigenetically Orchestrates Osteogenic and Adipogenic Differentiation of Bone Marrow Mesenchymal Stem Cells to Delay Bone Aging

Abstract With the increase in the aging population, senile osteoporosis (SOP) has become a major global public health concern. Here, it is found that Prx1 and Bmi‐1 co‐localized in trabecular bone, bone marrow cavity, endosteum, and periosteum. Prx1‐driven Bmi‐1 knockout in bone‐marrow mesenchymal s...

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Bibliographic Details
Main Authors: Jingyu Zhao, Ao Chen, Rong Wang, Dong Qiu, Haiyun Chen, Jiyu Li, Jin'ge Zhang, Tianxiao Wang, Yue Wang, Yujie Lin, Jiawen Zhou, Yifei Du, Hua Yuan, Yongjie Zhang, Dengshun Miao, Yuli Wang, Jianliang Jin
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Advanced Science
Subjects:
Bmi‐1
bone marrow mesenchymal stem cells
DNA methylation
DNMT3A
H3K27 trimethylation
senile osteoporosis
Online Access:https://doi.org/10.1002/advs.202404518
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