Neurologic adverse events of cancer immunotherapy
ABSTRACT Cancer immunotherapy encompasses a wide range of treatment modalities that harness the anti-tumor effects of the immune system and have revolutionized oncological treatment in recent years, with approval for its use in more and more cancers. However, it is not without side effects. Several...
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Thieme Revinter Publicações
2022-08-01
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| Series: | Arquivos de Neuro-Psiquiatria |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2022000700270&tlng=en |
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| _version_ | 1849306707983859712 |
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| author | Marcelo Houat de Brito |
| author_facet | Marcelo Houat de Brito |
| author_sort | Marcelo Houat de Brito |
| collection | DOAJ |
| description | ABSTRACT Cancer immunotherapy encompasses a wide range of treatment modalities that harness the anti-tumor effects of the immune system and have revolutionized oncological treatment in recent years, with approval for its use in more and more cancers. However, it is not without side effects. Several neurological adverse events have been recognized associated with immune checkpoint inhibitors (ICI) and chimeric antigen receptor (CAR) T-cell therapy, the two main classes of cancer immunotherapy. With the increase in the prevalence of oncological diseases and this type of therapy, it is improbable that neurologists, oncologists, hematologists, and other healthcare professionals who deal with cancer patients will not encounter this type of neurologic complication in their practice in the following years. This article aims to review the epidemiology, clinical manifestations, diagnosis, and management of neurological complications associated with ICI and CAR T-cell therapy. |
| format | Article |
| id | doaj-art-2c93ba9176ac4dd7a9ac8f2fb6ab8c6e |
| institution | Kabale University |
| issn | 1678-4227 |
| language | English |
| publishDate | 2022-08-01 |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-2c93ba9176ac4dd7a9ac8f2fb6ab8c6e2025-08-20T03:55:00ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria1678-42272022-08-01805 suppl 127028010.1590/0004-282x-anp-2022-s116Neurologic adverse events of cancer immunotherapyMarcelo Houat de Britohttps://orcid.org/0000-0001-7521-1388ABSTRACT Cancer immunotherapy encompasses a wide range of treatment modalities that harness the anti-tumor effects of the immune system and have revolutionized oncological treatment in recent years, with approval for its use in more and more cancers. However, it is not without side effects. Several neurological adverse events have been recognized associated with immune checkpoint inhibitors (ICI) and chimeric antigen receptor (CAR) T-cell therapy, the two main classes of cancer immunotherapy. With the increase in the prevalence of oncological diseases and this type of therapy, it is improbable that neurologists, oncologists, hematologists, and other healthcare professionals who deal with cancer patients will not encounter this type of neurologic complication in their practice in the following years. This article aims to review the epidemiology, clinical manifestations, diagnosis, and management of neurological complications associated with ICI and CAR T-cell therapy.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2022000700270&tlng=enImmune Checkpoint InhibitorsImmunotherapy, AdoptiveDrug-Related Side Effects and Adverse ReactionsNeurologic ManifestationsNeuromuscular Diseases |
| spellingShingle | Marcelo Houat de Brito Neurologic adverse events of cancer immunotherapy Arquivos de Neuro-Psiquiatria Immune Checkpoint Inhibitors Immunotherapy, Adoptive Drug-Related Side Effects and Adverse Reactions Neurologic Manifestations Neuromuscular Diseases |
| title | Neurologic adverse events of cancer immunotherapy |
| title_full | Neurologic adverse events of cancer immunotherapy |
| title_fullStr | Neurologic adverse events of cancer immunotherapy |
| title_full_unstemmed | Neurologic adverse events of cancer immunotherapy |
| title_short | Neurologic adverse events of cancer immunotherapy |
| title_sort | neurologic adverse events of cancer immunotherapy |
| topic | Immune Checkpoint Inhibitors Immunotherapy, Adoptive Drug-Related Side Effects and Adverse Reactions Neurologic Manifestations Neuromuscular Diseases |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2022000700270&tlng=en |
| work_keys_str_mv | AT marcelohouatdebrito neurologicadverseeventsofcancerimmunotherapy |