Impact of shear wave elastography and attenuation imaging for predicting life-threatening event in patients with metabolic dysfunction-associated steatotic liver disease
Abstract We aimed to elucidate the value of ultrasound-based biomarkers for predicting the major life-threatening events in metabolic dysfunction-associated steatotic liver disease (MASLD). We established a prospective cohort of 279 patients who underwent two-dimensional shear wave elastography (2D-...
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Nature Portfolio
2025-02-01
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| Online Access: | https://doi.org/10.1038/s41598-025-87974-w |
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| author | Yudai Fujiwara Hidekatsu Kuroda Tamami Abe Tomoaki Nagasawa Ippeki Nakaya Asami Ito Takuya Watanabe Kenji Yusa Hiroki Sato Akiko Suzuki Kei Endo Yuichi Yoshida Takayoshi Oikawa Keisuke Kakisaka Kei Sawara Toshifumi Tada Akio Miyasaka Takuma Oguri Naohisa Kamiyama Takayuki Matsumoto |
| author_facet | Yudai Fujiwara Hidekatsu Kuroda Tamami Abe Tomoaki Nagasawa Ippeki Nakaya Asami Ito Takuya Watanabe Kenji Yusa Hiroki Sato Akiko Suzuki Kei Endo Yuichi Yoshida Takayoshi Oikawa Keisuke Kakisaka Kei Sawara Toshifumi Tada Akio Miyasaka Takuma Oguri Naohisa Kamiyama Takayuki Matsumoto |
| author_sort | Yudai Fujiwara |
| collection | DOAJ |
| description | Abstract We aimed to elucidate the value of ultrasound-based biomarkers for predicting the major life-threatening events in metabolic dysfunction-associated steatotic liver disease (MASLD). We established a prospective cohort of 279 patients who underwent two-dimensional shear wave elastography (2D-SWE), ultrasound-guided attenuation parameter (UGAP). An area under the curve analysis was performed to determine the cutoff values of liver stiffness measurements (LSM) by 2D-SWE and attenuation coefficient (AC) by UGAP for a moderate fibrosis and a moderate steatosis. We then classified the cohort into Groups A (low LSM and low AC), B (low LSM and high AC), C (high LSM and high AC), and D (high LSM and low AC). We compared the incidence of events between the groups, and estimated the hazard ratios (HRs) with 95% confidence intervals (CIs). The LSM and AC cut off values were 8.37 kPa and 0.62 dB/cm/MHz, respectively. The cumulative incidence rate in Groups A, B, C, and D were 11.2%, 12.2%, 29.5%, and 31.0%/5years, respectively (p < 0.05). LSM (HRs = 1.20, 95%CIs: 1.09–1.32, p < 0.01), and AC (HRs = 1.62, 95%CIs: 1.04–2.51, p = 0.03) were associated with life-threatening events. A combination of 2D-SWE and UGAP may help identify patients with MASLD at high risk for subsequent life-threatening events. |
| format | Article |
| id | doaj-art-2c93172a12084ae7bd2f6c0ba21ebe4c |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-2c93172a12084ae7bd2f6c0ba21ebe4c2025-02-09T12:34:54ZengNature PortfolioScientific Reports2045-23222025-02-0115111010.1038/s41598-025-87974-wImpact of shear wave elastography and attenuation imaging for predicting life-threatening event in patients with metabolic dysfunction-associated steatotic liver diseaseYudai Fujiwara0Hidekatsu Kuroda1Tamami Abe2Tomoaki Nagasawa3Ippeki Nakaya4Asami Ito5Takuya Watanabe6Kenji Yusa7Hiroki Sato8Akiko Suzuki9Kei Endo10Yuichi Yoshida11Takayoshi Oikawa12Keisuke Kakisaka13Kei Sawara14Toshifumi Tada15Akio Miyasaka16Takuma Oguri17Naohisa Kamiyama18Takayuki Matsumoto19Division of Gastroenterology and Hepatology, Department of Internal Medicine, Iwate Medical UniversityDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Iwate Medical UniversityDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Iwate Medical UniversityDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Iwate Medical UniversityDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Iwate Medical UniversityDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Iwate Medical UniversityDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Iwate Medical UniversityDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Iwate Medical UniversityDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Iwate Medical UniversityDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Iwate Medical UniversityDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Iwate Medical UniversityDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Iwate Medical UniversityDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Iwate Medical UniversityDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Iwate Medical UniversityDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Iwate Medical UniversityDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Iwate Medical UniversityDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Iwate Medical UniversityUltrasound General Imaging, GE HealthCareUltrasound General Imaging, GE HealthCareDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Iwate Medical UniversityAbstract We aimed to elucidate the value of ultrasound-based biomarkers for predicting the major life-threatening events in metabolic dysfunction-associated steatotic liver disease (MASLD). We established a prospective cohort of 279 patients who underwent two-dimensional shear wave elastography (2D-SWE), ultrasound-guided attenuation parameter (UGAP). An area under the curve analysis was performed to determine the cutoff values of liver stiffness measurements (LSM) by 2D-SWE and attenuation coefficient (AC) by UGAP for a moderate fibrosis and a moderate steatosis. We then classified the cohort into Groups A (low LSM and low AC), B (low LSM and high AC), C (high LSM and high AC), and D (high LSM and low AC). We compared the incidence of events between the groups, and estimated the hazard ratios (HRs) with 95% confidence intervals (CIs). The LSM and AC cut off values were 8.37 kPa and 0.62 dB/cm/MHz, respectively. The cumulative incidence rate in Groups A, B, C, and D were 11.2%, 12.2%, 29.5%, and 31.0%/5years, respectively (p < 0.05). LSM (HRs = 1.20, 95%CIs: 1.09–1.32, p < 0.01), and AC (HRs = 1.62, 95%CIs: 1.04–2.51, p = 0.03) were associated with life-threatening events. A combination of 2D-SWE and UGAP may help identify patients with MASLD at high risk for subsequent life-threatening events.https://doi.org/10.1038/s41598-025-87974-wHepatic steatosisMetabolic dysfunction-associated steatotic liver diseaseShear wave elastographyUltrasound-guided attenuation parameter |
| spellingShingle | Yudai Fujiwara Hidekatsu Kuroda Tamami Abe Tomoaki Nagasawa Ippeki Nakaya Asami Ito Takuya Watanabe Kenji Yusa Hiroki Sato Akiko Suzuki Kei Endo Yuichi Yoshida Takayoshi Oikawa Keisuke Kakisaka Kei Sawara Toshifumi Tada Akio Miyasaka Takuma Oguri Naohisa Kamiyama Takayuki Matsumoto Impact of shear wave elastography and attenuation imaging for predicting life-threatening event in patients with metabolic dysfunction-associated steatotic liver disease Scientific Reports Hepatic steatosis Metabolic dysfunction-associated steatotic liver disease Shear wave elastography Ultrasound-guided attenuation parameter |
| title | Impact of shear wave elastography and attenuation imaging for predicting life-threatening event in patients with metabolic dysfunction-associated steatotic liver disease |
| title_full | Impact of shear wave elastography and attenuation imaging for predicting life-threatening event in patients with metabolic dysfunction-associated steatotic liver disease |
| title_fullStr | Impact of shear wave elastography and attenuation imaging for predicting life-threatening event in patients with metabolic dysfunction-associated steatotic liver disease |
| title_full_unstemmed | Impact of shear wave elastography and attenuation imaging for predicting life-threatening event in patients with metabolic dysfunction-associated steatotic liver disease |
| title_short | Impact of shear wave elastography and attenuation imaging for predicting life-threatening event in patients with metabolic dysfunction-associated steatotic liver disease |
| title_sort | impact of shear wave elastography and attenuation imaging for predicting life threatening event in patients with metabolic dysfunction associated steatotic liver disease |
| topic | Hepatic steatosis Metabolic dysfunction-associated steatotic liver disease Shear wave elastography Ultrasound-guided attenuation parameter |
| url | https://doi.org/10.1038/s41598-025-87974-w |
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