Early-onset neonatal sepsis in a Chinese maternal and child healthcare centre, 2017–2023
ObjectiveEarly-onset sepsis (EOS) remains an important issue in neonatal units. Characteristics of EOS from China have not been fully revealed yet. Our aim is to investigate epidemiology, microbiology and clinical feature of EOS in a Chinese maternal and child healthcare centre.MethodsThis is a retr...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-04-01
|
| Series: | Frontiers in Pediatrics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2025.1521908/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850150578636718080 |
|---|---|
| author | Weilin Wang Zhenhui Wang Linghua Wang Suping Li Jiangling Liu Yaqin Huang Jun Liu Chun Zhu Juan Zhang Cairong Li Chunjia Yang Qiong Chen Wenqin Wang Shulin Deng Yiming Du |
| author_facet | Weilin Wang Zhenhui Wang Linghua Wang Suping Li Jiangling Liu Yaqin Huang Jun Liu Chun Zhu Juan Zhang Cairong Li Chunjia Yang Qiong Chen Wenqin Wang Shulin Deng Yiming Du |
| author_sort | Weilin Wang |
| collection | DOAJ |
| description | ObjectiveEarly-onset sepsis (EOS) remains an important issue in neonatal units. Characteristics of EOS from China have not been fully revealed yet. Our aim is to investigate epidemiology, microbiology and clinical feature of EOS in a Chinese maternal and child healthcare centre.MethodsThis is a retrospective observational study of EOS infants born in or admitted to Hunan Provincial Maternal and Child Health Care Hospital from January 1, 2017 to December 31, 2023.ResultsDuring the study period, there were 131 neonatal infections. The incidence of EOS was 1.12 (95% CI 0.94–1.33) per 1,000 live births or 3.85 (95% CI 3.22–4.56) per 1,000 admissions. Coagulase-negative staphylococci (CoNS) (n = 43, 32.3%), group B Streptococcus (GBS) (n = 24, 18.0%) and Escherichia coli (n = 18, 13.5%) were the predominant pathogens. GBS screening test was performed before delivery in 77.7% mothers of all infants with EOS, and 12.9% of screening results were positive. Among the main pathogens causing EOS, 86% of CoNS strains were resistant to penicillin, while all GBS strains were susceptible to penicillin.ConclusionsWe report a high burden of EOS among infants in the maternal and child healthcare centre from China. CoNS was the most frequent pathogen causing EOS. Longitudinal epidemiologic surveillance is required to improve empiric antibiotic treatment of EOS. |
| format | Article |
| id | doaj-art-2c92cee6c0cd49f28ab29f98586e163e |
| institution | OA Journals |
| issn | 2296-2360 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj-art-2c92cee6c0cd49f28ab29f98586e163e2025-08-20T02:26:31ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602025-04-011310.3389/fped.2025.15219081521908Early-onset neonatal sepsis in a Chinese maternal and child healthcare centre, 2017–2023Weilin Wang0Zhenhui Wang1Linghua Wang2Suping Li3Jiangling Liu4Yaqin Huang5Jun Liu6Chun Zhu7Juan Zhang8Cairong Li9Chunjia Yang10Qiong Chen11Wenqin Wang12Shulin Deng13Yiming Du14Department of Neonatology, Hunan Provincial Maternal and Child Health Care Hospital, University of South China, Changsha, Hunan, ChinaDepartment of Obstetrics, Hunan Provincial Maternal and Child Health Care Hospital, University of South China, Changsha, Hunan, ChinaDepartment of Neonatology, Hunan Provincial Maternal and Child Health Care Hospital, University of South China, Changsha, Hunan, ChinaDepartment of Neonatology, Hunan Provincial Maternal and Child Health Care Hospital, University of South China, Changsha, Hunan, ChinaDepartment of Neonatology, Hunan Provincial Maternal and Child Health Care Hospital, University of South China, Changsha, Hunan, ChinaDepartment of Neonatology, Hunan Provincial Maternal and Child Health Care Hospital, University of South China, Changsha, Hunan, ChinaDepartment of Clinical Laboratory, Hunan Provincial Maternal and Child Health Care Hospital, University of South China, Changsha, Hunan, ChinaDepartment of Obstetrics, Hunan Provincial Maternal and Child Health Care Hospital, University of South China, Changsha, Hunan, ChinaDepartment of Neonatology, Hunan Provincial Maternal and Child Health Care Hospital, University of South China, Changsha, Hunan, ChinaDepartment of Neonatology, Hunan Provincial Maternal and Child Health Care Hospital, University of South China, Changsha, Hunan, ChinaDepartment of Neonatology, Hunan Provincial Maternal and Child Health Care Hospital, University of South China, Changsha, Hunan, ChinaDepartment of Neonatology, Hunan Provincial Maternal and Child Health Care Hospital, University of South China, Changsha, Hunan, ChinaDepartment of Neonatology, Hunan Provincial Maternal and Child Health Care Hospital, University of South China, Changsha, Hunan, ChinaDepartment of Neonatology, Hunan Provincial Maternal and Child Health Care Hospital, University of South China, Changsha, Hunan, ChinaDepartment of Neonatology, Hunan Provincial Maternal and Child Health Care Hospital, University of South China, Changsha, Hunan, ChinaObjectiveEarly-onset sepsis (EOS) remains an important issue in neonatal units. Characteristics of EOS from China have not been fully revealed yet. Our aim is to investigate epidemiology, microbiology and clinical feature of EOS in a Chinese maternal and child healthcare centre.MethodsThis is a retrospective observational study of EOS infants born in or admitted to Hunan Provincial Maternal and Child Health Care Hospital from January 1, 2017 to December 31, 2023.ResultsDuring the study period, there were 131 neonatal infections. The incidence of EOS was 1.12 (95% CI 0.94–1.33) per 1,000 live births or 3.85 (95% CI 3.22–4.56) per 1,000 admissions. Coagulase-negative staphylococci (CoNS) (n = 43, 32.3%), group B Streptococcus (GBS) (n = 24, 18.0%) and Escherichia coli (n = 18, 13.5%) were the predominant pathogens. GBS screening test was performed before delivery in 77.7% mothers of all infants with EOS, and 12.9% of screening results were positive. Among the main pathogens causing EOS, 86% of CoNS strains were resistant to penicillin, while all GBS strains were susceptible to penicillin.ConclusionsWe report a high burden of EOS among infants in the maternal and child healthcare centre from China. CoNS was the most frequent pathogen causing EOS. Longitudinal epidemiologic surveillance is required to improve empiric antibiotic treatment of EOS.https://www.frontiersin.org/articles/10.3389/fped.2025.1521908/fullearly-onset sepsisincidenceantimicrobial resistancesurveillancepathogens |
| spellingShingle | Weilin Wang Zhenhui Wang Linghua Wang Suping Li Jiangling Liu Yaqin Huang Jun Liu Chun Zhu Juan Zhang Cairong Li Chunjia Yang Qiong Chen Wenqin Wang Shulin Deng Yiming Du Early-onset neonatal sepsis in a Chinese maternal and child healthcare centre, 2017–2023 Frontiers in Pediatrics early-onset sepsis incidence antimicrobial resistance surveillance pathogens |
| title | Early-onset neonatal sepsis in a Chinese maternal and child healthcare centre, 2017–2023 |
| title_full | Early-onset neonatal sepsis in a Chinese maternal and child healthcare centre, 2017–2023 |
| title_fullStr | Early-onset neonatal sepsis in a Chinese maternal and child healthcare centre, 2017–2023 |
| title_full_unstemmed | Early-onset neonatal sepsis in a Chinese maternal and child healthcare centre, 2017–2023 |
| title_short | Early-onset neonatal sepsis in a Chinese maternal and child healthcare centre, 2017–2023 |
| title_sort | early onset neonatal sepsis in a chinese maternal and child healthcare centre 2017 2023 |
| topic | early-onset sepsis incidence antimicrobial resistance surveillance pathogens |
| url | https://www.frontiersin.org/articles/10.3389/fped.2025.1521908/full |
| work_keys_str_mv | AT weilinwang earlyonsetneonatalsepsisinachinesematernalandchildhealthcarecentre20172023 AT zhenhuiwang earlyonsetneonatalsepsisinachinesematernalandchildhealthcarecentre20172023 AT linghuawang earlyonsetneonatalsepsisinachinesematernalandchildhealthcarecentre20172023 AT supingli earlyonsetneonatalsepsisinachinesematernalandchildhealthcarecentre20172023 AT jianglingliu earlyonsetneonatalsepsisinachinesematernalandchildhealthcarecentre20172023 AT yaqinhuang earlyonsetneonatalsepsisinachinesematernalandchildhealthcarecentre20172023 AT junliu earlyonsetneonatalsepsisinachinesematernalandchildhealthcarecentre20172023 AT chunzhu earlyonsetneonatalsepsisinachinesematernalandchildhealthcarecentre20172023 AT juanzhang earlyonsetneonatalsepsisinachinesematernalandchildhealthcarecentre20172023 AT cairongli earlyonsetneonatalsepsisinachinesematernalandchildhealthcarecentre20172023 AT chunjiayang earlyonsetneonatalsepsisinachinesematernalandchildhealthcarecentre20172023 AT qiongchen earlyonsetneonatalsepsisinachinesematernalandchildhealthcarecentre20172023 AT wenqinwang earlyonsetneonatalsepsisinachinesematernalandchildhealthcarecentre20172023 AT shulindeng earlyonsetneonatalsepsisinachinesematernalandchildhealthcarecentre20172023 AT yimingdu earlyonsetneonatalsepsisinachinesematernalandchildhealthcarecentre20172023 |