Selective reporting of antibiotic susceptibility testing results: a retrospective evaluation of a nudging strategy to improve antibiotic prescribing for ampC-producing infections in hospitalized adults
Background: Moderate-risk ampC beta-lactamase-producing Enterobacterales (HECK-Yes organisms) render many beta-lactams ineffective. Objective: This study evaluates selective reporting (SR) of antimicrobial susceptibility testing (AST) results to improve antibiotic prescribing for these infections. D...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2025-06-01
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| Series: | Therapeutic Advances in Infectious Disease |
| Online Access: | https://doi.org/10.1177/20499361251338017 |
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| author | Andy Lim Terrence McSweeney Phyu M. Thwe Mei H. Chang Hongkai Bao Philip Lee Kelsie Cowman Priya Nori Yi Guo |
| author_facet | Andy Lim Terrence McSweeney Phyu M. Thwe Mei H. Chang Hongkai Bao Philip Lee Kelsie Cowman Priya Nori Yi Guo |
| author_sort | Andy Lim |
| collection | DOAJ |
| description | Background: Moderate-risk ampC beta-lactamase-producing Enterobacterales (HECK-Yes organisms) render many beta-lactams ineffective. Objective: This study evaluates selective reporting (SR) of antimicrobial susceptibility testing (AST) results to improve antibiotic prescribing for these infections. Design: A retrospective quasi-experimental study evaluating patients before and after the implementation of SR. Methods: SR of AST results for HECK-Yes organisms was implemented at a 1500-bed medical center. A retrospective study compared antibiotic prescribing before and after implementation in patients with positive blood or respiratory cultures. Results: Fifty patients were included in both pre- and post-implementation groups with similar baseline characteristics. Post-implementation, appropriate antibiotics within 24 h of AST report increased by 24% (62% pre vs 86% post, p = 0.01). A total of 30-day mortality, clinical success, and microbiological failure rates were similar between groups. Conclusion: SR improved appropriate antibiotic prescribing for moderate-risk ampC-producing Enterobacterales (e.g., HECK-Yes) infections. |
| format | Article |
| id | doaj-art-2c90505e3ab94ea58f9b22f00ccfbab9 |
| institution | OA Journals |
| issn | 2049-937X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Infectious Disease |
| spelling | doaj-art-2c90505e3ab94ea58f9b22f00ccfbab92025-08-20T02:10:17ZengSAGE PublishingTherapeutic Advances in Infectious Disease2049-937X2025-06-011210.1177/20499361251338017Selective reporting of antibiotic susceptibility testing results: a retrospective evaluation of a nudging strategy to improve antibiotic prescribing for ampC-producing infections in hospitalized adultsAndy LimTerrence McSweeneyPhyu M. ThweMei H. ChangHongkai BaoPhilip LeeKelsie CowmanPriya NoriYi GuoBackground: Moderate-risk ampC beta-lactamase-producing Enterobacterales (HECK-Yes organisms) render many beta-lactams ineffective. Objective: This study evaluates selective reporting (SR) of antimicrobial susceptibility testing (AST) results to improve antibiotic prescribing for these infections. Design: A retrospective quasi-experimental study evaluating patients before and after the implementation of SR. Methods: SR of AST results for HECK-Yes organisms was implemented at a 1500-bed medical center. A retrospective study compared antibiotic prescribing before and after implementation in patients with positive blood or respiratory cultures. Results: Fifty patients were included in both pre- and post-implementation groups with similar baseline characteristics. Post-implementation, appropriate antibiotics within 24 h of AST report increased by 24% (62% pre vs 86% post, p = 0.01). A total of 30-day mortality, clinical success, and microbiological failure rates were similar between groups. Conclusion: SR improved appropriate antibiotic prescribing for moderate-risk ampC-producing Enterobacterales (e.g., HECK-Yes) infections.https://doi.org/10.1177/20499361251338017 |
| spellingShingle | Andy Lim Terrence McSweeney Phyu M. Thwe Mei H. Chang Hongkai Bao Philip Lee Kelsie Cowman Priya Nori Yi Guo Selective reporting of antibiotic susceptibility testing results: a retrospective evaluation of a nudging strategy to improve antibiotic prescribing for ampC-producing infections in hospitalized adults Therapeutic Advances in Infectious Disease |
| title | Selective reporting of antibiotic susceptibility testing results: a retrospective evaluation of a nudging strategy to improve antibiotic prescribing for ampC-producing infections in hospitalized adults |
| title_full | Selective reporting of antibiotic susceptibility testing results: a retrospective evaluation of a nudging strategy to improve antibiotic prescribing for ampC-producing infections in hospitalized adults |
| title_fullStr | Selective reporting of antibiotic susceptibility testing results: a retrospective evaluation of a nudging strategy to improve antibiotic prescribing for ampC-producing infections in hospitalized adults |
| title_full_unstemmed | Selective reporting of antibiotic susceptibility testing results: a retrospective evaluation of a nudging strategy to improve antibiotic prescribing for ampC-producing infections in hospitalized adults |
| title_short | Selective reporting of antibiotic susceptibility testing results: a retrospective evaluation of a nudging strategy to improve antibiotic prescribing for ampC-producing infections in hospitalized adults |
| title_sort | selective reporting of antibiotic susceptibility testing results a retrospective evaluation of a nudging strategy to improve antibiotic prescribing for ampc producing infections in hospitalized adults |
| url | https://doi.org/10.1177/20499361251338017 |
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