The EZH2 selective inhibitor ZLD1039 attenuates UUO-induced renal fibrosis by suppressing YAP activation

The EZH2 selective inhibitor ZLD1039 attenuates UUO-induced renal fibrosis by suppressing YAP activation

Abstract Renal fibrosis is a manifestation of the progression of chronic kidney disease (CKD) and chronic inflammation is a main driver in the development of renal fibrosis. Yes-associated protein (YAP), acting as a transcriptional co-activator within the Hippo signaling pathway, has been implicated...

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Bibliographic Details
Main Authors: Qingling Xia, Fujiang Xu, Lidan Zhang, Wenfei Ding, Jiang Liu, Jing Liu, Minhao Chen, Santao Ou, Yong Xu, Li Wen
Format: Article
Language:English
Published: Springer 2025-06-01
Series:Molecular Biomedicine
Subjects:
Enhancer of zeste homolog 2
Large tumor suppressor 1
Yes-associated protein 1
Inflammation
Renal fibrosis
Online Access:https://doi.org/10.1186/s43556-025-00276-5
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