TMEM33 as a Prognostic Biomarker of Cervical Cancer and Its Correlation with Immune Infiltration
In women all over the world, cervical cancer (CC) ranks as the fourth most common form of cancer to be diagnosed. It was previously reported that transmembrane protein 33(TMEM33) could report a poor prognosis in several cancers. The current study is aimed at investigating the potential prognostic va...
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2023/5542181 |
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| _version_ | 1849699316940144640 |
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| author | Hui Zhang Jun Wang Ji Yang Qingwen He Sanli Guan Minxia Qiao Jian Zhao Xiu Wang |
| author_facet | Hui Zhang Jun Wang Ji Yang Qingwen He Sanli Guan Minxia Qiao Jian Zhao Xiu Wang |
| author_sort | Hui Zhang |
| collection | DOAJ |
| description | In women all over the world, cervical cancer (CC) ranks as the fourth most common form of cancer to be diagnosed. It was previously reported that transmembrane protein 33(TMEM33) could report a poor prognosis in several cancers. The current study is aimed at investigating the potential prognostic value of TMEM33 and its relevance to the tumor microenvironment in CC in a comprehensive manner. In this study, CC specimens presented noticeably higher TMEM33 expression level in comparison to nontumor specimens. In pan-cancer assays, it was found that TMEM33 was present at a high level in many different kinds of tumors. We found that patients with CC patients who had a high TMEM33 expression presented worse overall survival (OS) and disease-free survival (DFS) relative to patients who had a low TMEM33 expression. According to the results of a multivariate analysis, a high level of TMEM33 expression can significantly and independently predict the prognosis of CC. The levels of TMEM33 were found to have a negative correlation with resting dendritic cells, resting mast cells, plasma cells, T cells CD8, T cells regulatory, and regulatory T cells. Finally, we confirmed that TMEM33 was overexpressed in CC cells, and its knockdown distinctly suppressed the proliferation and invasion of CC cells. Overall, we provided evidences that TMEM33 could be used as a potential biomarker to assess the prognosis and the level of immune infiltration in CC. |
| format | Article |
| id | doaj-art-2c8a715e667d46df93d07d729561ebf6 |
| institution | DOAJ |
| issn | 1466-1861 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-2c8a715e667d46df93d07d729561ebf62025-08-20T03:18:38ZengWileyMediators of Inflammation1466-18612023-01-01202310.1155/2023/5542181TMEM33 as a Prognostic Biomarker of Cervical Cancer and Its Correlation with Immune InfiltrationHui Zhang0Jun Wang1Ji Yang2Qingwen He3Sanli Guan4Minxia Qiao5Jian Zhao6Xiu Wang7Department of UltrasoundDepartment of UltrasoundDepartment of UltrasoundDepartment of UltrasoundDepartment of UltrasoundDepartment of UltrasoundDepartment of UltrasoundDepartment of UltrasoundIn women all over the world, cervical cancer (CC) ranks as the fourth most common form of cancer to be diagnosed. It was previously reported that transmembrane protein 33(TMEM33) could report a poor prognosis in several cancers. The current study is aimed at investigating the potential prognostic value of TMEM33 and its relevance to the tumor microenvironment in CC in a comprehensive manner. In this study, CC specimens presented noticeably higher TMEM33 expression level in comparison to nontumor specimens. In pan-cancer assays, it was found that TMEM33 was present at a high level in many different kinds of tumors. We found that patients with CC patients who had a high TMEM33 expression presented worse overall survival (OS) and disease-free survival (DFS) relative to patients who had a low TMEM33 expression. According to the results of a multivariate analysis, a high level of TMEM33 expression can significantly and independently predict the prognosis of CC. The levels of TMEM33 were found to have a negative correlation with resting dendritic cells, resting mast cells, plasma cells, T cells CD8, T cells regulatory, and regulatory T cells. Finally, we confirmed that TMEM33 was overexpressed in CC cells, and its knockdown distinctly suppressed the proliferation and invasion of CC cells. Overall, we provided evidences that TMEM33 could be used as a potential biomarker to assess the prognosis and the level of immune infiltration in CC.http://dx.doi.org/10.1155/2023/5542181 |
| spellingShingle | Hui Zhang Jun Wang Ji Yang Qingwen He Sanli Guan Minxia Qiao Jian Zhao Xiu Wang TMEM33 as a Prognostic Biomarker of Cervical Cancer and Its Correlation with Immune Infiltration Mediators of Inflammation |
| title | TMEM33 as a Prognostic Biomarker of Cervical Cancer and Its Correlation with Immune Infiltration |
| title_full | TMEM33 as a Prognostic Biomarker of Cervical Cancer and Its Correlation with Immune Infiltration |
| title_fullStr | TMEM33 as a Prognostic Biomarker of Cervical Cancer and Its Correlation with Immune Infiltration |
| title_full_unstemmed | TMEM33 as a Prognostic Biomarker of Cervical Cancer and Its Correlation with Immune Infiltration |
| title_short | TMEM33 as a Prognostic Biomarker of Cervical Cancer and Its Correlation with Immune Infiltration |
| title_sort | tmem33 as a prognostic biomarker of cervical cancer and its correlation with immune infiltration |
| url | http://dx.doi.org/10.1155/2023/5542181 |
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