Assessment of the Chemical Diversity and Functional Properties of Secondary Metabolites from the Marine Fungus <i>Asteromyces cruciatus</i>
Natural compounds derived from microorganisms, especially those with antioxidant and anticancer properties, are gaining attention for their potential applications in biomedical, cosmetic, and food industries. Marine fungi, such as <i>Asteromyces cruciatus</i>, are particularly promising...
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MDPI AG
2024-12-01
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| Series: | Journal of Fungi |
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| Online Access: | https://www.mdpi.com/2309-608X/11/1/3 |
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| author | María Paz González-Troncoso Catalina Landeta-Salgado Javiera Munizaga Ruth Hornedo-Ortega María del Carmen García-Parrilla María Elena Lienqueo |
| author_facet | María Paz González-Troncoso Catalina Landeta-Salgado Javiera Munizaga Ruth Hornedo-Ortega María del Carmen García-Parrilla María Elena Lienqueo |
| author_sort | María Paz González-Troncoso |
| collection | DOAJ |
| description | Natural compounds derived from microorganisms, especially those with antioxidant and anticancer properties, are gaining attention for their potential applications in biomedical, cosmetic, and food industries. Marine fungi, such as <i>Asteromyces cruciatus</i>, are particularly promising due to their ability to produce bioactive metabolites through the degradation of marine algal polysaccharides. This study investigates the metabolic diversity of <i>A. cruciatus</i> grown on different carbon sources: glucose, <i>Durvillaea</i> spp., and <i>Macrocystis pyrifera</i>. Crude extracts of fungal biomass were analyzed for total phenolic content (TPC), antioxidant capacity (TAC), toxicity, and phenolic compound identification using ultra-high-performance liquid chromatography coupled with high-resolution electrospray ionization mass spectrometry (UHPLC-MS/MS). The analysis revealed the presence of anthraquinone compounds, including emodin (0.36 ± 0.08 mg/g DW biomass) and citrereosein in glucose medium and citrereosein and endocrocin in <i>M. pyrifera</i> medium. No such compounds were detected in <i>Durvillaea</i> spp. medium. The glucose-grown extract exhibited the highest TPC (3.09 ± 0.04 mg GAE/g DW) and TAC (39.70 ± 1.0 µmol TEq/g biomass). Additionally, no detrimental effects were observed on a neuronal cell line. These findings highlight the influence of carbon sources on the production of bioactive metabolites and their functional properties, providing valuable insights into the biotechnological potential of <i>A. cruciatus</i>. |
| format | Article |
| id | doaj-art-2c86935cb5294d3bbb3ee2df32a4dfbc |
| institution | Kabale University |
| issn | 2309-608X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Fungi |
| spelling | doaj-art-2c86935cb5294d3bbb3ee2df32a4dfbc2025-01-24T13:37:11ZengMDPI AGJournal of Fungi2309-608X2024-12-01111310.3390/jof11010003Assessment of the Chemical Diversity and Functional Properties of Secondary Metabolites from the Marine Fungus <i>Asteromyces cruciatus</i>María Paz González-Troncoso0Catalina Landeta-Salgado1Javiera Munizaga2Ruth Hornedo-Ortega3María del Carmen García-Parrilla4María Elena Lienqueo5Department of Chemical Engineering, Biotechnology, and Materials, Centre for Biotechnology and Bioengineering (CeBiB), University of Chile, Beauchef 851, Santiago 8370456, ChileDepartment of Chemical Engineering, Biotechnology, and Materials, Centre for Biotechnology and Bioengineering (CeBiB), University of Chile, Beauchef 851, Santiago 8370456, ChileDepartment of Chemical Engineering, Biotechnology, and Materials, Centre for Biotechnology and Bioengineering (CeBiB), University of Chile, Beauchef 851, Santiago 8370456, ChileDepartamento de Nutrición y Bromatología, Toxicología y Medicina Legal, Facultad de Farmacia, Universidad de Sevilla, C/Profesor García González nº 2, 41012 Sevilla, SpainDepartamento de Nutrición y Bromatología, Toxicología y Medicina Legal, Facultad de Farmacia, Universidad de Sevilla, C/Profesor García González nº 2, 41012 Sevilla, SpainDepartment of Chemical Engineering, Biotechnology, and Materials, Centre for Biotechnology and Bioengineering (CeBiB), University of Chile, Beauchef 851, Santiago 8370456, ChileNatural compounds derived from microorganisms, especially those with antioxidant and anticancer properties, are gaining attention for their potential applications in biomedical, cosmetic, and food industries. Marine fungi, such as <i>Asteromyces cruciatus</i>, are particularly promising due to their ability to produce bioactive metabolites through the degradation of marine algal polysaccharides. This study investigates the metabolic diversity of <i>A. cruciatus</i> grown on different carbon sources: glucose, <i>Durvillaea</i> spp., and <i>Macrocystis pyrifera</i>. Crude extracts of fungal biomass were analyzed for total phenolic content (TPC), antioxidant capacity (TAC), toxicity, and phenolic compound identification using ultra-high-performance liquid chromatography coupled with high-resolution electrospray ionization mass spectrometry (UHPLC-MS/MS). The analysis revealed the presence of anthraquinone compounds, including emodin (0.36 ± 0.08 mg/g DW biomass) and citrereosein in glucose medium and citrereosein and endocrocin in <i>M. pyrifera</i> medium. No such compounds were detected in <i>Durvillaea</i> spp. medium. The glucose-grown extract exhibited the highest TPC (3.09 ± 0.04 mg GAE/g DW) and TAC (39.70 ± 1.0 µmol TEq/g biomass). Additionally, no detrimental effects were observed on a neuronal cell line. These findings highlight the influence of carbon sources on the production of bioactive metabolites and their functional properties, providing valuable insights into the biotechnological potential of <i>A. cruciatus</i>.https://www.mdpi.com/2309-608X/11/1/3anthraquinone compoundsbioactive compoundsphenolic compoundsmetabolomemarine-derived fungi<i>Asteromyces cruciatus</i> |
| spellingShingle | María Paz González-Troncoso Catalina Landeta-Salgado Javiera Munizaga Ruth Hornedo-Ortega María del Carmen García-Parrilla María Elena Lienqueo Assessment of the Chemical Diversity and Functional Properties of Secondary Metabolites from the Marine Fungus <i>Asteromyces cruciatus</i> Journal of Fungi anthraquinone compounds bioactive compounds phenolic compounds metabolome marine-derived fungi <i>Asteromyces cruciatus</i> |
| title | Assessment of the Chemical Diversity and Functional Properties of Secondary Metabolites from the Marine Fungus <i>Asteromyces cruciatus</i> |
| title_full | Assessment of the Chemical Diversity and Functional Properties of Secondary Metabolites from the Marine Fungus <i>Asteromyces cruciatus</i> |
| title_fullStr | Assessment of the Chemical Diversity and Functional Properties of Secondary Metabolites from the Marine Fungus <i>Asteromyces cruciatus</i> |
| title_full_unstemmed | Assessment of the Chemical Diversity and Functional Properties of Secondary Metabolites from the Marine Fungus <i>Asteromyces cruciatus</i> |
| title_short | Assessment of the Chemical Diversity and Functional Properties of Secondary Metabolites from the Marine Fungus <i>Asteromyces cruciatus</i> |
| title_sort | assessment of the chemical diversity and functional properties of secondary metabolites from the marine fungus i asteromyces cruciatus i |
| topic | anthraquinone compounds bioactive compounds phenolic compounds metabolome marine-derived fungi <i>Asteromyces cruciatus</i> |
| url | https://www.mdpi.com/2309-608X/11/1/3 |
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