Terpenoids from quinoa reverse chemoresistance in breast cancer by suppressing the stemness‐related lncRNA 667012
Abstract Chemoresistance is a major cause of breast cancer (BC) recurrence and metastasis, and chemotherapy resistance comes from tumor stemness. Our previous study showed that quinoa bran terpenoids (QBT) exhibited significant antitumor activity. In this study, we found that QBT increased the sensi...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-01-01
|
| Series: | Food Frontiers |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/fft2.503 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849328195390668800 |
|---|---|
| author | Xiaxia Fan Mangmang Feng Dan Guo Songtao Li Yuxuan An Jinmiao Tian Zhuoyu Li |
| author_facet | Xiaxia Fan Mangmang Feng Dan Guo Songtao Li Yuxuan An Jinmiao Tian Zhuoyu Li |
| author_sort | Xiaxia Fan |
| collection | DOAJ |
| description | Abstract Chemoresistance is a major cause of breast cancer (BC) recurrence and metastasis, and chemotherapy resistance comes from tumor stemness. Our previous study showed that quinoa bran terpenoids (QBT) exhibited significant antitumor activity. In this study, we found that QBT increased the sensitivity of drug‐resistant BC cells to the chemotherapeutic drugs adriamycin (ADR) and taxol (TAX). A novel lncRNA 667012 was identified along with QBT treatment. Moreover, overexpression of lncRNA 667012 promoted drug resistance, and the reduction of 667012 restored the drug sensitivity of resistant BC cells. More importantly, the findings revealed that lncRNA 667012 promoted stemness maintenance via the stemness‐related Wnt pathway. Furthermore, the result showed that QBT reduced 667012 expression and inhibited the activation of β‐catenin, thereby attenuating the stemness characteristics of BC and enhancing chemosensitivity. Consistently, the data were confirmed in the xenograft mice model. These results suggest that QBT could reverse chemoresistance by inhibiting stemness. It has the potential to be developed as a novel chemotherapeutic agent or chemosensitizer for BC treatment. |
| format | Article |
| id | doaj-art-2c84e7f5861043bca24c4dfd198ee0dc |
| institution | Kabale University |
| issn | 2643-8429 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Food Frontiers |
| spelling | doaj-art-2c84e7f5861043bca24c4dfd198ee0dc2025-08-20T03:47:40ZengWileyFood Frontiers2643-84292025-01-016151653110.1002/fft2.503Terpenoids from quinoa reverse chemoresistance in breast cancer by suppressing the stemness‐related lncRNA 667012Xiaxia Fan0Mangmang Feng1Dan Guo2Songtao Li3Yuxuan An4Jinmiao Tian5Zhuoyu Li6Key Laboratory of Chemical Biology and Molecular Engineering of the National Ministry of Education, Institute of BiotechnologyShanxi UniversityTaiyuanChinaKey Laboratory of Chemical Biology and Molecular Engineering of the National Ministry of Education, Institute of BiotechnologyShanxi UniversityTaiyuanChinaKey Laboratory of Chemical Biology and Molecular Engineering of the National Ministry of Education, Institute of BiotechnologyShanxi UniversityTaiyuanChinaKey Laboratory of Chemical Biology and Molecular Engineering of the National Ministry of Education, Institute of BiotechnologyShanxi UniversityTaiyuanChinaKey Laboratory of Chemical Biology and Molecular Engineering of the National Ministry of Education, Institute of BiotechnologyShanxi UniversityTaiyuanChinaKey Laboratory of Chemical Biology and Molecular Engineering of the National Ministry of Education, Institute of BiotechnologyShanxi UniversityTaiyuanChinaKey Laboratory of Chemical Biology and Molecular Engineering of the National Ministry of Education, Institute of BiotechnologyShanxi UniversityTaiyuanChinaAbstract Chemoresistance is a major cause of breast cancer (BC) recurrence and metastasis, and chemotherapy resistance comes from tumor stemness. Our previous study showed that quinoa bran terpenoids (QBT) exhibited significant antitumor activity. In this study, we found that QBT increased the sensitivity of drug‐resistant BC cells to the chemotherapeutic drugs adriamycin (ADR) and taxol (TAX). A novel lncRNA 667012 was identified along with QBT treatment. Moreover, overexpression of lncRNA 667012 promoted drug resistance, and the reduction of 667012 restored the drug sensitivity of resistant BC cells. More importantly, the findings revealed that lncRNA 667012 promoted stemness maintenance via the stemness‐related Wnt pathway. Furthermore, the result showed that QBT reduced 667012 expression and inhibited the activation of β‐catenin, thereby attenuating the stemness characteristics of BC and enhancing chemosensitivity. Consistently, the data were confirmed in the xenograft mice model. These results suggest that QBT could reverse chemoresistance by inhibiting stemness. It has the potential to be developed as a novel chemotherapeutic agent or chemosensitizer for BC treatment.https://doi.org/10.1002/fft2.503Breast cancerChemoresistanceLncRNA 667012QBTStemness |
| spellingShingle | Xiaxia Fan Mangmang Feng Dan Guo Songtao Li Yuxuan An Jinmiao Tian Zhuoyu Li Terpenoids from quinoa reverse chemoresistance in breast cancer by suppressing the stemness‐related lncRNA 667012 Food Frontiers Breast cancer Chemoresistance LncRNA 667012 QBT Stemness |
| title | Terpenoids from quinoa reverse chemoresistance in breast cancer by suppressing the stemness‐related lncRNA 667012 |
| title_full | Terpenoids from quinoa reverse chemoresistance in breast cancer by suppressing the stemness‐related lncRNA 667012 |
| title_fullStr | Terpenoids from quinoa reverse chemoresistance in breast cancer by suppressing the stemness‐related lncRNA 667012 |
| title_full_unstemmed | Terpenoids from quinoa reverse chemoresistance in breast cancer by suppressing the stemness‐related lncRNA 667012 |
| title_short | Terpenoids from quinoa reverse chemoresistance in breast cancer by suppressing the stemness‐related lncRNA 667012 |
| title_sort | terpenoids from quinoa reverse chemoresistance in breast cancer by suppressing the stemness related lncrna 667012 |
| topic | Breast cancer Chemoresistance LncRNA 667012 QBT Stemness |
| url | https://doi.org/10.1002/fft2.503 |
| work_keys_str_mv | AT xiaxiafan terpenoidsfromquinoareversechemoresistanceinbreastcancerbysuppressingthestemnessrelatedlncrna667012 AT mangmangfeng terpenoidsfromquinoareversechemoresistanceinbreastcancerbysuppressingthestemnessrelatedlncrna667012 AT danguo terpenoidsfromquinoareversechemoresistanceinbreastcancerbysuppressingthestemnessrelatedlncrna667012 AT songtaoli terpenoidsfromquinoareversechemoresistanceinbreastcancerbysuppressingthestemnessrelatedlncrna667012 AT yuxuanan terpenoidsfromquinoareversechemoresistanceinbreastcancerbysuppressingthestemnessrelatedlncrna667012 AT jinmiaotian terpenoidsfromquinoareversechemoresistanceinbreastcancerbysuppressingthestemnessrelatedlncrna667012 AT zhuoyuli terpenoidsfromquinoareversechemoresistanceinbreastcancerbysuppressingthestemnessrelatedlncrna667012 |