Role of probiotics in prevention and treatment of diarrhea and disbiosis in infants
Intestinal microbiota is a complex ecosystem of the community of enteric microorganisms and is estimated as an individual metabolic organ. Bifidobacteria and Lactobacilli are the predominant microbes in a colon of healthy infants, they are able to suppress a growth of pathogenic and conditionally pa...
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| Format: | Article |
| Language: | Russian |
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Open Systems Publication
2021-12-01
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| Series: | Лечащий Врач |
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| Online Access: | https://journal.lvrach.ru/jour/article/view/839 |
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| author | S. G. Gribakin |
| author_facet | S. G. Gribakin |
| author_sort | S. G. Gribakin |
| collection | DOAJ |
| description | Intestinal microbiota is a complex ecosystem of the community of enteric microorganisms and is estimated as an individual metabolic organ. Bifidobacteria and Lactobacilli are the predominant microbes in a colon of healthy infants, they are able to suppress a growth of pathogenic and conditionally pathogenic microorganisms and support a development of immune system. Over the past 10 years, research in the field of molecular biology and genome structure of Bifidobacterium and Lactobacillus has focused on such problems as interaction with the immune system and the prospects for their use in antibiotic-associated diarrhea and diarrhea in pediatric practice, as well as in irritable bowel syndrome and inflammatory bowel disease. In recent years, a number of clinical studies have been carried out on the use of probiotics for the treatment and prevention of diarrhea in children, and several detailed analytical meta-analyzes have been prepared, which give a fairly complete picture of the possibilities of using monocomponent and combined probiotic drugs. Important facts have been obtained in favor of the fact that certain strains of Lactobacilli and Bifidobacteria are immunomodulators and are able to influence immune regulation by affecting the balance between pro-inflammatory and anti-inflammatory cytokines. Another mechanism of action of probiotic drugs is their effect on dopamine and serotonin receptors, due to which a positive effect of probiotics has been established in patients under stress and in depression. The article shows that combined probiotic remedies are characterized by synergic action and have an antibacterial effect and immune modulation. Combined probiotics are characterized by synergic activity and support a development of immune system. Due to these properties they have a clinically proven effect in diarrhea and disbiosis in infants. |
| format | Article |
| id | doaj-art-2c7faa82008845f498d8bc6bcd52d81f |
| institution | Kabale University |
| issn | 1560-5175 2687-1181 |
| language | Russian |
| publishDate | 2021-12-01 |
| publisher | Open Systems Publication |
| record_format | Article |
| series | Лечащий Врач |
| spelling | doaj-art-2c7faa82008845f498d8bc6bcd52d81f2025-08-20T03:57:51ZrusOpen Systems PublicationЛечащий Врач1560-51752687-11812021-12-01111576210.51793/OS.2021.24.11.009837Role of probiotics in prevention and treatment of diarrhea and disbiosis in infantsS. G. Gribakin0Russian Medical Academy of Continuous Professional Education of the Ministry of Health of Russian FederationIntestinal microbiota is a complex ecosystem of the community of enteric microorganisms and is estimated as an individual metabolic organ. Bifidobacteria and Lactobacilli are the predominant microbes in a colon of healthy infants, they are able to suppress a growth of pathogenic and conditionally pathogenic microorganisms and support a development of immune system. Over the past 10 years, research in the field of molecular biology and genome structure of Bifidobacterium and Lactobacillus has focused on such problems as interaction with the immune system and the prospects for their use in antibiotic-associated diarrhea and diarrhea in pediatric practice, as well as in irritable bowel syndrome and inflammatory bowel disease. In recent years, a number of clinical studies have been carried out on the use of probiotics for the treatment and prevention of diarrhea in children, and several detailed analytical meta-analyzes have been prepared, which give a fairly complete picture of the possibilities of using monocomponent and combined probiotic drugs. Important facts have been obtained in favor of the fact that certain strains of Lactobacilli and Bifidobacteria are immunomodulators and are able to influence immune regulation by affecting the balance between pro-inflammatory and anti-inflammatory cytokines. Another mechanism of action of probiotic drugs is their effect on dopamine and serotonin receptors, due to which a positive effect of probiotics has been established in patients under stress and in depression. The article shows that combined probiotic remedies are characterized by synergic action and have an antibacterial effect and immune modulation. Combined probiotics are characterized by synergic activity and support a development of immune system. Due to these properties they have a clinically proven effect in diarrhea and disbiosis in infants.https://journal.lvrach.ru/jour/article/view/839intestinal microbiotaprobioticsimmune modulationbifidobacterialactobacillidiarrheadisbiosis |
| spellingShingle | S. G. Gribakin Role of probiotics in prevention and treatment of diarrhea and disbiosis in infants Лечащий Врач intestinal microbiota probiotics immune modulation bifidobacteria lactobacilli diarrhea disbiosis |
| title | Role of probiotics in prevention and treatment of diarrhea and disbiosis in infants |
| title_full | Role of probiotics in prevention and treatment of diarrhea and disbiosis in infants |
| title_fullStr | Role of probiotics in prevention and treatment of diarrhea and disbiosis in infants |
| title_full_unstemmed | Role of probiotics in prevention and treatment of diarrhea and disbiosis in infants |
| title_short | Role of probiotics in prevention and treatment of diarrhea and disbiosis in infants |
| title_sort | role of probiotics in prevention and treatment of diarrhea and disbiosis in infants |
| topic | intestinal microbiota probiotics immune modulation bifidobacteria lactobacilli diarrhea disbiosis |
| url | https://journal.lvrach.ru/jour/article/view/839 |
| work_keys_str_mv | AT sggribakin roleofprobioticsinpreventionandtreatmentofdiarrheaanddisbiosisininfants |