Role of intrinsic and supplemented antioxidants in follicular fluid: a shield against oxidative stress in oocyte health and embryo development
Background: In In Vitro Fertilization (IVF), a form of Assisted Reproductive Technologies (ART), the quality of oocytes and the successful development of embryos are crucial in determining the rate of fertility. The excessive presence of ROS (Reactive Oxygen Species) can cause oxidative stress, whic...
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| Format: | Article |
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Creative Pharma Assent
2025-06-01
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| Series: | Journal of Applied Pharmaceutical Research |
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| Online Access: | https://japtronline.com/index.php/joapr/article/view/1036 |
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| author | Nidhi Gairola Himanko Gogoi Janhvi Dubey Jasvinder Singh Khatiyaan Harsh Chaudhary |
| author_facet | Nidhi Gairola Himanko Gogoi Janhvi Dubey Jasvinder Singh Khatiyaan Harsh Chaudhary |
| author_sort | Nidhi Gairola |
| collection | DOAJ |
| description | Background: In In Vitro Fertilization (IVF), a form of Assisted Reproductive Technologies (ART), the quality of oocytes and the successful development of embryos are crucial in determining the rate of fertility. The excessive presence of ROS (Reactive Oxygen Species) can cause oxidative stress, which negatively affects follicular fluid (FF) and oocyte maturation. Certain non-endogenous antioxidants, such as catalase, glutathione, and Superoxide Dismutase (SOD), are already present in Follicular fluid, which counterbalances these ROS and protects oocytes. Method: In addition to examining the possibility of exogenous supplements of antioxidants, such as vitamins C and E, and Coenzyme Q10 (CoQ10), this review investigates the function of these intrinsic antioxidants in maintaining oocyte health. Result: According to current in vivo and in vitro research findings done in mice, pigs, sheep, cows, and 18 patients in the age group(40±1), respectively, targeted antioxidant supplementation may enhance oocyte quality, embryo viability, and pregnancy outcomes. Conclusion: However, addressing individual heterogeneity in oxidative stress and optimizing dosage remains challenging. This review highlights how new antioxidant compounds and targeted interventions may enhance reproductive success by promoting cellular resilience in follicular fluid (FF). However, additional research into targeted antioxidant therapy in IVF is necessary. |
| format | Article |
| id | doaj-art-2c792e47aa094c459e4d99102aa21acc |
| institution | DOAJ |
| issn | 2348-0335 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Creative Pharma Assent |
| record_format | Article |
| series | Journal of Applied Pharmaceutical Research |
| spelling | doaj-art-2c792e47aa094c459e4d99102aa21acc2025-08-20T02:56:51ZengCreative Pharma AssentJournal of Applied Pharmaceutical Research2348-03352025-06-011339410410.69857/joapr.v13i3.10361037Role of intrinsic and supplemented antioxidants in follicular fluid: a shield against oxidative stress in oocyte health and embryo developmentNidhi Gairola0Himanko Gogoi1Janhvi Dubey2Jasvinder Singh Khatiyaan3Harsh Chaudhary4Department of Pharmacology, School of Pharmaceutical Sciences, Shri Guru Ram Rai University, Uttarakhand 248001, IndiaUttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Uttarakhand 248007, IndiaUttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Uttarakhand 248007, IndiaUttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Uttarakhand 248007, IndiaUttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Uttarakhand 248007, IndiaBackground: In In Vitro Fertilization (IVF), a form of Assisted Reproductive Technologies (ART), the quality of oocytes and the successful development of embryos are crucial in determining the rate of fertility. The excessive presence of ROS (Reactive Oxygen Species) can cause oxidative stress, which negatively affects follicular fluid (FF) and oocyte maturation. Certain non-endogenous antioxidants, such as catalase, glutathione, and Superoxide Dismutase (SOD), are already present in Follicular fluid, which counterbalances these ROS and protects oocytes. Method: In addition to examining the possibility of exogenous supplements of antioxidants, such as vitamins C and E, and Coenzyme Q10 (CoQ10), this review investigates the function of these intrinsic antioxidants in maintaining oocyte health. Result: According to current in vivo and in vitro research findings done in mice, pigs, sheep, cows, and 18 patients in the age group(40±1), respectively, targeted antioxidant supplementation may enhance oocyte quality, embryo viability, and pregnancy outcomes. Conclusion: However, addressing individual heterogeneity in oxidative stress and optimizing dosage remains challenging. This review highlights how new antioxidant compounds and targeted interventions may enhance reproductive success by promoting cellular resilience in follicular fluid (FF). However, additional research into targeted antioxidant therapy in IVF is necessary.https://japtronline.com/index.php/joapr/article/view/1036antioxidantscoenzymefollicular fluidintrinsicin vitro fertilization |
| spellingShingle | Nidhi Gairola Himanko Gogoi Janhvi Dubey Jasvinder Singh Khatiyaan Harsh Chaudhary Role of intrinsic and supplemented antioxidants in follicular fluid: a shield against oxidative stress in oocyte health and embryo development Journal of Applied Pharmaceutical Research antioxidants coenzyme follicular fluid intrinsic in vitro fertilization |
| title | Role of intrinsic and supplemented antioxidants in follicular fluid: a shield against oxidative stress in oocyte health and embryo development |
| title_full | Role of intrinsic and supplemented antioxidants in follicular fluid: a shield against oxidative stress in oocyte health and embryo development |
| title_fullStr | Role of intrinsic and supplemented antioxidants in follicular fluid: a shield against oxidative stress in oocyte health and embryo development |
| title_full_unstemmed | Role of intrinsic and supplemented antioxidants in follicular fluid: a shield against oxidative stress in oocyte health and embryo development |
| title_short | Role of intrinsic and supplemented antioxidants in follicular fluid: a shield against oxidative stress in oocyte health and embryo development |
| title_sort | role of intrinsic and supplemented antioxidants in follicular fluid a shield against oxidative stress in oocyte health and embryo development |
| topic | antioxidants coenzyme follicular fluid intrinsic in vitro fertilization |
| url | https://japtronline.com/index.php/joapr/article/view/1036 |
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