A Review of the Physiological and Immunological Functions of Biliary Epithelial Cells: Targets for Primary Biliary Cirrhosis, Primary Sclerosing Cholangitis and Drug-induced Ductopenias
Our understanding of biliary epithelial cells (BEC) in physiobiology and immunology has steadily expanded. BEC transports IgA as well as IgM into bile, synthesizes and secretes various chemokines, cytokines, and expresses adhesion molecules involved in cell intera...
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| Format: | Article |
| Language: | English |
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Wiley
2004-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1080/17402520400004177 |
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| author | Chih-Te Wu Paul A. Davis VelImir A. Luketic M. Eric Gershwin |
| author_facet | Chih-Te Wu Paul A. Davis VelImir A. Luketic M. Eric Gershwin |
| author_sort | Chih-Te Wu |
| collection | DOAJ |
| description | Our understanding of biliary epithelial cells (BEC) in physiobiology and
immunology has steadily expanded. BEC transports IgA as well as IgM into bile,
synthesizes and secretes various chemokines, cytokines, and expresses adhesion
molecules involved in cell interaction and signal transduction. These then suggest
a myriad of potential roles for BEC in defense from invading microorganisms as well
as the pathogenesis of diverse immunologically driven diseases such as primary
biliary cirrhosis (PBC), graft-versus-host disease, and primary sclerosing cholangitis
(PSC). Despite the progress, there still remain many areas of BEC biology that
require further investigation. Most importantly, it remains to be clarified that the
extent to which the immunologic activities observed in BEC represent a BEC
response to tissue injury or whether BEC themselves are the active participants
in the pathogenesis of various cholestatic immunological diseases, including PBC
and PSC. |
| format | Article |
| id | doaj-art-2c78f108fff84c059804a8a61219ba3e |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2004-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-2c78f108fff84c059804a8a61219ba3e2025-02-03T06:14:01ZengWileyClinical and Developmental Immunology1740-25221740-25302004-01-01113-420521310.1080/17402520400004177A Review of the Physiological and Immunological Functions of Biliary Epithelial Cells: Targets for Primary Biliary Cirrhosis, Primary Sclerosing Cholangitis and Drug-induced DuctopeniasChih-Te Wu0Paul A. Davis1VelImir A. Luketic2M. Eric Gershwin3Division of Rheumatology, Allergy and Clinical Immunology, University of California, Davis School of Medicine, Davis 95616, CA, USADivision of Rheumatology, Allergy and Clinical Immunology, University of California, Davis School of Medicine, Davis 95616, CA, USADivision of Hepatology, Medical College of Virginia, Richmond 23298, VA, USADivision of Hepatology, Medical College of Virginia, Richmond 23298, VA, USAOur understanding of biliary epithelial cells (BEC) in physiobiology and immunology has steadily expanded. BEC transports IgA as well as IgM into bile, synthesizes and secretes various chemokines, cytokines, and expresses adhesion molecules involved in cell interaction and signal transduction. These then suggest a myriad of potential roles for BEC in defense from invading microorganisms as well as the pathogenesis of diverse immunologically driven diseases such as primary biliary cirrhosis (PBC), graft-versus-host disease, and primary sclerosing cholangitis (PSC). Despite the progress, there still remain many areas of BEC biology that require further investigation. Most importantly, it remains to be clarified that the extent to which the immunologic activities observed in BEC represent a BEC response to tissue injury or whether BEC themselves are the active participants in the pathogenesis of various cholestatic immunological diseases, including PBC and PSC.http://dx.doi.org/10.1080/17402520400004177 |
| spellingShingle | Chih-Te Wu Paul A. Davis VelImir A. Luketic M. Eric Gershwin A Review of the Physiological and Immunological Functions of Biliary Epithelial Cells: Targets for Primary Biliary Cirrhosis, Primary Sclerosing Cholangitis and Drug-induced Ductopenias Clinical and Developmental Immunology |
| title | A Review of the Physiological and Immunological Functions of Biliary Epithelial Cells: Targets for Primary Biliary Cirrhosis, Primary Sclerosing Cholangitis and Drug-induced Ductopenias |
| title_full | A Review of the Physiological and Immunological Functions of Biliary Epithelial Cells: Targets for Primary Biliary Cirrhosis, Primary Sclerosing Cholangitis and Drug-induced Ductopenias |
| title_fullStr | A Review of the Physiological and Immunological Functions of Biliary Epithelial Cells: Targets for Primary Biliary Cirrhosis, Primary Sclerosing Cholangitis and Drug-induced Ductopenias |
| title_full_unstemmed | A Review of the Physiological and Immunological Functions of Biliary Epithelial Cells: Targets for Primary Biliary Cirrhosis, Primary Sclerosing Cholangitis and Drug-induced Ductopenias |
| title_short | A Review of the Physiological and Immunological Functions of Biliary Epithelial Cells: Targets for Primary Biliary Cirrhosis, Primary Sclerosing Cholangitis and Drug-induced Ductopenias |
| title_sort | review of the physiological and immunological functions of biliary epithelial cells targets for primary biliary cirrhosis primary sclerosing cholangitis and drug induced ductopenias |
| url | http://dx.doi.org/10.1080/17402520400004177 |
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