Thyroid, neurodevelopmental, and kidney toxicities of common organic UV filters in embryo-larval zebrafish (Danio rerio), and their potential links
Organic UV filters (OUVFs) have been commonly used in sunscreen and many consumer products. Following dermal application, these compounds can enter circulation and may cause systemic effects in humans. In the present study, we chose four OUVFs frequently detected in the environment, i.e., avobenzone...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-10-01
|
| Series: | Environment International |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412024006160 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850210451294519296 |
|---|---|
| author | Ba Reum Kwon Ah-Reum Jo Inae Lee Gowoon Lee Young Joo Park Jung Pyo Lee Na-Youn Park Younglim Kho Sungkyoon Kim Kyunghee Ji Kyungho Choi |
| author_facet | Ba Reum Kwon Ah-Reum Jo Inae Lee Gowoon Lee Young Joo Park Jung Pyo Lee Na-Youn Park Younglim Kho Sungkyoon Kim Kyunghee Ji Kyungho Choi |
| author_sort | Ba Reum Kwon |
| collection | DOAJ |
| description | Organic UV filters (OUVFs) have been commonly used in sunscreen and many consumer products. Following dermal application, these compounds can enter circulation and may cause systemic effects in humans. In the present study, we chose four OUVFs frequently detected in the environment, i.e., avobenzone (AVB), benzophenone-3 (BP-3), octocrylene (OC), and octyl methoxycinnamate (OMC), and evaluated their thyroid, neurodevelopmental, and kidney toxicities. For this purpose, zebrafish embryos (<4 h post fertilization, hpf) were exposed to sublethal concentrations of AVB, BP-3, OC, or OMC until 120 hpf. Exposure to all OUVFs decreased thyroid hormone (TH) levels, probably by enhanced metabolism and excretion of THs (ugt1ab and/or sult1 st5) in the larval fish. Exposure to the OUVFs also induced hypoactivities and/or anxiety-like behaviors: Regulatory changes of mbp, gfap, c-fos, syn2a, sty1a, and stxbp1b genes, support the changes in normal neurobehavior of the larval fish. Moreover, the OUVFs exposure caused increased proteinuria in the fish, along with transcriptional changes of wt1, nephrin, podocin, and cdh17 genes, which could explain the observed reduction in kidney functions. Principal component analysis (PCA) implied the potential interplay of THs with neurogenesis, or podocyte differentiation of the larval fish. Toxicological consequences of altered TH homeostasis, neurobehavior, and kidney function at the early life stage warrant further investigations not only in humans but also in aquatic ecosystems. |
| format | Article |
| id | doaj-art-2c77ed12debe4c9fabed197bd181fc9b |
| institution | OA Journals |
| issn | 0160-4120 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Environment International |
| spelling | doaj-art-2c77ed12debe4c9fabed197bd181fc9b2025-08-20T02:09:47ZengElsevierEnvironment International0160-41202024-10-0119210903010.1016/j.envint.2024.109030Thyroid, neurodevelopmental, and kidney toxicities of common organic UV filters in embryo-larval zebrafish (Danio rerio), and their potential linksBa Reum Kwon0Ah-Reum Jo1Inae Lee2Gowoon Lee3Young Joo Park4Jung Pyo Lee5Na-Youn Park6Younglim Kho7Sungkyoon Kim8Kyunghee Ji9Kyungho Choi10Graduate School of Public Health, Seoul National University, Seoul 08826, Republic of KoreaGraduate School of Public Health, Seoul National University, Seoul 08826, Republic of KoreaGraduate School of Public Health, Seoul National University, Seoul 08826, Republic of KoreaDepartment of Safety Engineering, Korea National University of Transportation, Chungju, Chungbuk 27469, Republic of KoreaDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea; Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 03080, Republic of KoreaDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea; Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul 07061, Republic of KoreaDepartment of Health, Environment & Safety, Eulji University, Seongnam, Gyeonggi 13135, Republic of KoreaDepartment of Health, Environment & Safety, Eulji University, Seongnam, Gyeonggi 13135, Republic of KoreaGraduate School of Public Health, Seoul National University, Seoul 08826, Republic of KoreaDepartment of Environmental Health, Yongin University, Yongin, Gyeonggi 17092, Republic of Korea; Department of Occupational and Environmental Health, Yongin University, Yongin, Gyeonggi 17092, Republic of KoreaGraduate School of Public Health, Seoul National University, Seoul 08826, Republic of Korea; Corresponding author.Organic UV filters (OUVFs) have been commonly used in sunscreen and many consumer products. Following dermal application, these compounds can enter circulation and may cause systemic effects in humans. In the present study, we chose four OUVFs frequently detected in the environment, i.e., avobenzone (AVB), benzophenone-3 (BP-3), octocrylene (OC), and octyl methoxycinnamate (OMC), and evaluated their thyroid, neurodevelopmental, and kidney toxicities. For this purpose, zebrafish embryos (<4 h post fertilization, hpf) were exposed to sublethal concentrations of AVB, BP-3, OC, or OMC until 120 hpf. Exposure to all OUVFs decreased thyroid hormone (TH) levels, probably by enhanced metabolism and excretion of THs (ugt1ab and/or sult1 st5) in the larval fish. Exposure to the OUVFs also induced hypoactivities and/or anxiety-like behaviors: Regulatory changes of mbp, gfap, c-fos, syn2a, sty1a, and stxbp1b genes, support the changes in normal neurobehavior of the larval fish. Moreover, the OUVFs exposure caused increased proteinuria in the fish, along with transcriptional changes of wt1, nephrin, podocin, and cdh17 genes, which could explain the observed reduction in kidney functions. Principal component analysis (PCA) implied the potential interplay of THs with neurogenesis, or podocyte differentiation of the larval fish. Toxicological consequences of altered TH homeostasis, neurobehavior, and kidney function at the early life stage warrant further investigations not only in humans but also in aquatic ecosystems.http://www.sciencedirect.com/science/article/pii/S0160412024006160Endocrine disruptionUV filtersThyroid hormoneDevelopmental neurotoxicityKidney toxicityZebrafish |
| spellingShingle | Ba Reum Kwon Ah-Reum Jo Inae Lee Gowoon Lee Young Joo Park Jung Pyo Lee Na-Youn Park Younglim Kho Sungkyoon Kim Kyunghee Ji Kyungho Choi Thyroid, neurodevelopmental, and kidney toxicities of common organic UV filters in embryo-larval zebrafish (Danio rerio), and their potential links Environment International Endocrine disruption UV filters Thyroid hormone Developmental neurotoxicity Kidney toxicity Zebrafish |
| title | Thyroid, neurodevelopmental, and kidney toxicities of common organic UV filters in embryo-larval zebrafish (Danio rerio), and their potential links |
| title_full | Thyroid, neurodevelopmental, and kidney toxicities of common organic UV filters in embryo-larval zebrafish (Danio rerio), and their potential links |
| title_fullStr | Thyroid, neurodevelopmental, and kidney toxicities of common organic UV filters in embryo-larval zebrafish (Danio rerio), and their potential links |
| title_full_unstemmed | Thyroid, neurodevelopmental, and kidney toxicities of common organic UV filters in embryo-larval zebrafish (Danio rerio), and their potential links |
| title_short | Thyroid, neurodevelopmental, and kidney toxicities of common organic UV filters in embryo-larval zebrafish (Danio rerio), and their potential links |
| title_sort | thyroid neurodevelopmental and kidney toxicities of common organic uv filters in embryo larval zebrafish danio rerio and their potential links |
| topic | Endocrine disruption UV filters Thyroid hormone Developmental neurotoxicity Kidney toxicity Zebrafish |
| url | http://www.sciencedirect.com/science/article/pii/S0160412024006160 |
| work_keys_str_mv | AT bareumkwon thyroidneurodevelopmentalandkidneytoxicitiesofcommonorganicuvfiltersinembryolarvalzebrafishdaniorerioandtheirpotentiallinks AT ahreumjo thyroidneurodevelopmentalandkidneytoxicitiesofcommonorganicuvfiltersinembryolarvalzebrafishdaniorerioandtheirpotentiallinks AT inaelee thyroidneurodevelopmentalandkidneytoxicitiesofcommonorganicuvfiltersinembryolarvalzebrafishdaniorerioandtheirpotentiallinks AT gowoonlee thyroidneurodevelopmentalandkidneytoxicitiesofcommonorganicuvfiltersinembryolarvalzebrafishdaniorerioandtheirpotentiallinks AT youngjoopark thyroidneurodevelopmentalandkidneytoxicitiesofcommonorganicuvfiltersinembryolarvalzebrafishdaniorerioandtheirpotentiallinks AT jungpyolee thyroidneurodevelopmentalandkidneytoxicitiesofcommonorganicuvfiltersinembryolarvalzebrafishdaniorerioandtheirpotentiallinks AT nayounpark thyroidneurodevelopmentalandkidneytoxicitiesofcommonorganicuvfiltersinembryolarvalzebrafishdaniorerioandtheirpotentiallinks AT younglimkho thyroidneurodevelopmentalandkidneytoxicitiesofcommonorganicuvfiltersinembryolarvalzebrafishdaniorerioandtheirpotentiallinks AT sungkyoonkim thyroidneurodevelopmentalandkidneytoxicitiesofcommonorganicuvfiltersinembryolarvalzebrafishdaniorerioandtheirpotentiallinks AT kyungheeji thyroidneurodevelopmentalandkidneytoxicitiesofcommonorganicuvfiltersinembryolarvalzebrafishdaniorerioandtheirpotentiallinks AT kyunghochoi thyroidneurodevelopmentalandkidneytoxicitiesofcommonorganicuvfiltersinembryolarvalzebrafishdaniorerioandtheirpotentiallinks |