Current and future of targeted therapies against BCR::ABL kinases

Abstract Chronic myeloid leukemia (CML) is a kind of leukemia that arises due to the translocation betwixt chromosomes 9 and 22. Philadelphia chromosome is characterized by the BCR::ABL fusion gene, which results from this recombination. It transcribes into active tyrosine kinase variants such as P1...

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Bibliographic Details
Main Authors: Sridhar Jayavel, Manasvini Subramanian, Pradeep Kumar Kesavan, Suresh Jayavel
Format: Article
Language:English
Published: SpringerOpen 2025-04-01
Series:Journal of the Egyptian National Cancer Institute
Subjects:
Online Access:https://doi.org/10.1186/s43046-025-00263-5
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