Acute mountain sickness: pathophysiology and prevention
This review discusses the epidemiology, pathophysiology, prevention and treatment of acute mountain sickness (AMS). Key mechanisms including changes in blood-brain barrier permeability, activation of the renin-angiotensin-aldosterone system and the role of diuresis in the development of AMS are ana...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nicolaus Copernicus University in Toruń
2025-01-01
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| Series: | Quality in Sport |
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| Online Access: | https://apcz.umk.pl/QS/article/view/57019 |
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| author | PAWEŁ MOCZYDŁOWSKI Karolina Kuczapska Anna Gliwa Monika Ryglewicz Dariusz Fabian Elżbieta Leszczyńska-Knaga Natalia Jakubczyk Weronika Rutkowska-Kawalec Marek Kurowski Karolina Michalczuk |
| author_facet | PAWEŁ MOCZYDŁOWSKI Karolina Kuczapska Anna Gliwa Monika Ryglewicz Dariusz Fabian Elżbieta Leszczyńska-Knaga Natalia Jakubczyk Weronika Rutkowska-Kawalec Marek Kurowski Karolina Michalczuk |
| author_sort | PAWEŁ MOCZYDŁOWSKI |
| collection | DOAJ |
| description |
This review discusses the epidemiology, pathophysiology, prevention and treatment of acute mountain sickness (AMS). Key mechanisms including changes in blood-brain barrier permeability, activation of the renin-angiotensin-aldosterone system and the role of diuresis in the development of AMS are analysed. The effectiveness of various preventive strategies, such as acclimatisation and pharmacotherapy (acetazolamide, dexamethasone, ibuprofen), as well as alternative approaches, including the use of natural remedies such as Rhodiola roses, coca leaves and Ginkgo biloba, are discussed. The paper emphasises the importance of correct diagnosis and prompt action in the treatment of AMS, which is crucial in preventing complications.
Material and methods
Data bases such as Pubmed and GoogleScholar were used for research with the key words: acute mountain illness (AMS), acetazolamid, dexametazone, altitude, prevention, acclimatisation.
Conclusions
Acute altitude sickness is a challenge in terms of understanding pathophyslogy and effective treatment methods. The primary methods of preventing AMS are properly managed acclimatisation and the use of acetazolamide. Other pharmacological and natural measures require further research.
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| format | Article |
| id | doaj-art-2c774327eb394c2d934e43d1704bb004 |
| institution | Kabale University |
| issn | 2450-3118 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nicolaus Copernicus University in Toruń |
| record_format | Article |
| series | Quality in Sport |
| spelling | doaj-art-2c774327eb394c2d934e43d1704bb0042025-01-21T08:23:01ZengNicolaus Copernicus University in ToruńQuality in Sport2450-31182025-01-013710.12775/QS.2025.37.57019Acute mountain sickness: pathophysiology and preventionPAWEŁ MOCZYDŁOWSKI0https://orcid.org/0009-0007-1555-2958Karolina Kuczapskahttps://orcid.org/0000-0002-5921-1094Anna Gliwahttps://orcid.org/0009-0006-0251-0591Monika Ryglewiczhttps://orcid.org/0009-0006-1063-2265Dariusz Fabianhttps://orcid.org/0009-0006-7241-7245Elżbieta Leszczyńska-Knagahttps://orcid.org/0009-0007-5584-8614Natalia Jakubczykhttps://orcid.org/0009-0008-3190-4658Weronika Rutkowska-Kawalechttps://orcid.org/0009-0002-4283-6458Marek Kurowskihttps://orcid.org/0009-0008-2831-3312Karolina Michalczukhttps://orcid.org/0000-0002-4427-9133Szpital Miejski Specjalistyczny im. Gabriela Narutowicza w Krakowie This review discusses the epidemiology, pathophysiology, prevention and treatment of acute mountain sickness (AMS). Key mechanisms including changes in blood-brain barrier permeability, activation of the renin-angiotensin-aldosterone system and the role of diuresis in the development of AMS are analysed. The effectiveness of various preventive strategies, such as acclimatisation and pharmacotherapy (acetazolamide, dexamethasone, ibuprofen), as well as alternative approaches, including the use of natural remedies such as Rhodiola roses, coca leaves and Ginkgo biloba, are discussed. The paper emphasises the importance of correct diagnosis and prompt action in the treatment of AMS, which is crucial in preventing complications. Material and methods Data bases such as Pubmed and GoogleScholar were used for research with the key words: acute mountain illness (AMS), acetazolamid, dexametazone, altitude, prevention, acclimatisation. Conclusions Acute altitude sickness is a challenge in terms of understanding pathophyslogy and effective treatment methods. The primary methods of preventing AMS are properly managed acclimatisation and the use of acetazolamide. Other pharmacological and natural measures require further research. https://apcz.umk.pl/QS/article/view/57019mountain sportsacute mountain sickness |
| spellingShingle | PAWEŁ MOCZYDŁOWSKI Karolina Kuczapska Anna Gliwa Monika Ryglewicz Dariusz Fabian Elżbieta Leszczyńska-Knaga Natalia Jakubczyk Weronika Rutkowska-Kawalec Marek Kurowski Karolina Michalczuk Acute mountain sickness: pathophysiology and prevention Quality in Sport mountain sports acute mountain sickness |
| title | Acute mountain sickness: pathophysiology and prevention |
| title_full | Acute mountain sickness: pathophysiology and prevention |
| title_fullStr | Acute mountain sickness: pathophysiology and prevention |
| title_full_unstemmed | Acute mountain sickness: pathophysiology and prevention |
| title_short | Acute mountain sickness: pathophysiology and prevention |
| title_sort | acute mountain sickness pathophysiology and prevention |
| topic | mountain sports acute mountain sickness |
| url | https://apcz.umk.pl/QS/article/view/57019 |
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