Significantly Decreased Islet β Cell Function is Closely Associated with Hyperglycemia in Chronic Hepatitis B Patients
Aim. This study is aimed at the characteristics of glucose metabolism and islet β cell function evaluated by the homeostasis model assessment of β cell function (HOMA-β) value and its risk factors in chronic hepatitis B (CHB) patients. Method. This cross-sectional study recruited 110 CHB patients (C...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2021/1264707 |
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| author | Dafeng Liu Lingyun Zhou Xinyi Zhang Yilan Zeng Lang Bai Dongbo Wu Hong Tang |
| author_facet | Dafeng Liu Lingyun Zhou Xinyi Zhang Yilan Zeng Lang Bai Dongbo Wu Hong Tang |
| author_sort | Dafeng Liu |
| collection | DOAJ |
| description | Aim. This study is aimed at the characteristics of glucose metabolism and islet β cell function evaluated by the homeostasis model assessment of β cell function (HOMA-β) value and its risk factors in chronic hepatitis B (CHB) patients. Method. This cross-sectional study recruited 110 CHB patients (CHB group) and 110 patients without hepatitis B virus (non-HBV group); the groups were matched according to sex, age, and body mass index under the same glucose metabolism status. The risk factors, characteristics, and differences in glucose metabolism and HOMA-β values between the two groups were analyzed. Results. The abnormal glucose metabolism rate was higher in CHB patients with liver cirrhosis (LC) or hepatitis B envelope antigen (HBeAg) (−) status. In addition, under the same glucose metabolism status, the fasting plasma glucose (FPG) levels and 2-hour postprandial plasma glucose (2h-PG) levels in the CHB group were higher, while the HOMA-β values were significantly lower and the homeostasis model assessment of insulin resistance (HOMA-IR) value was not higher than that in the non-HBV group (all P<0.0001). Further analyses revealed that the main risk factors for abnormal glucose metabolism were HBeAg (−) status and hepatitis B envelope antibody levels. But HBV serological and virological indicators had no effects on the HOMA-β values. Conclusion. Islet β cell function in patients with CHB was compromised, which is closely associated with fasting and postprandial hyperglycemia in chronic hepatitis B patients. Further research should be done to verify the compromised islet β cell function and then to investigate the mechanisms behind the effect of hepatitis B virus infection on islet β cell function in CHB patients. |
| format | Article |
| id | doaj-art-2c6fc93ba1964d1a8bf6e44dcbf60bf5 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-2c6fc93ba1964d1a8bf6e44dcbf60bf52025-08-20T03:55:17ZengWileyInternational Journal of Endocrinology1687-83371687-83452021-01-01202110.1155/2021/12647071264707Significantly Decreased Islet β Cell Function is Closely Associated with Hyperglycemia in Chronic Hepatitis B PatientsDafeng Liu0Lingyun Zhou1Xinyi Zhang2Yilan Zeng3Lang Bai4Dongbo Wu5Hong Tang6Center of Infectious Diseases, Sichuan University West China Hospital, Chengdu, ChinaCenter of Infectious Diseases, Sichuan University West China Hospital, Chengdu, ChinaDepartment of Endocrinology and Metabolism, Sichuan University West China Hospital, Chengdu, ChinaDepartment of Internal Medicine, The Public and Health Clinic Centre of Chengdu, Chengdu, ChinaCenter of Infectious Diseases, Sichuan University West China Hospital, Chengdu, ChinaCenter of Infectious Diseases, Sichuan University West China Hospital, Chengdu, ChinaCenter of Infectious Diseases, Sichuan University West China Hospital, Chengdu, ChinaAim. This study is aimed at the characteristics of glucose metabolism and islet β cell function evaluated by the homeostasis model assessment of β cell function (HOMA-β) value and its risk factors in chronic hepatitis B (CHB) patients. Method. This cross-sectional study recruited 110 CHB patients (CHB group) and 110 patients without hepatitis B virus (non-HBV group); the groups were matched according to sex, age, and body mass index under the same glucose metabolism status. The risk factors, characteristics, and differences in glucose metabolism and HOMA-β values between the two groups were analyzed. Results. The abnormal glucose metabolism rate was higher in CHB patients with liver cirrhosis (LC) or hepatitis B envelope antigen (HBeAg) (−) status. In addition, under the same glucose metabolism status, the fasting plasma glucose (FPG) levels and 2-hour postprandial plasma glucose (2h-PG) levels in the CHB group were higher, while the HOMA-β values were significantly lower and the homeostasis model assessment of insulin resistance (HOMA-IR) value was not higher than that in the non-HBV group (all P<0.0001). Further analyses revealed that the main risk factors for abnormal glucose metabolism were HBeAg (−) status and hepatitis B envelope antibody levels. But HBV serological and virological indicators had no effects on the HOMA-β values. Conclusion. Islet β cell function in patients with CHB was compromised, which is closely associated with fasting and postprandial hyperglycemia in chronic hepatitis B patients. Further research should be done to verify the compromised islet β cell function and then to investigate the mechanisms behind the effect of hepatitis B virus infection on islet β cell function in CHB patients.http://dx.doi.org/10.1155/2021/1264707 |
| spellingShingle | Dafeng Liu Lingyun Zhou Xinyi Zhang Yilan Zeng Lang Bai Dongbo Wu Hong Tang Significantly Decreased Islet β Cell Function is Closely Associated with Hyperglycemia in Chronic Hepatitis B Patients International Journal of Endocrinology |
| title | Significantly Decreased Islet β Cell Function is Closely Associated with Hyperglycemia in Chronic Hepatitis B Patients |
| title_full | Significantly Decreased Islet β Cell Function is Closely Associated with Hyperglycemia in Chronic Hepatitis B Patients |
| title_fullStr | Significantly Decreased Islet β Cell Function is Closely Associated with Hyperglycemia in Chronic Hepatitis B Patients |
| title_full_unstemmed | Significantly Decreased Islet β Cell Function is Closely Associated with Hyperglycemia in Chronic Hepatitis B Patients |
| title_short | Significantly Decreased Islet β Cell Function is Closely Associated with Hyperglycemia in Chronic Hepatitis B Patients |
| title_sort | significantly decreased islet β cell function is closely associated with hyperglycemia in chronic hepatitis b patients |
| url | http://dx.doi.org/10.1155/2021/1264707 |
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