An Assessment of Polar Solvent Extraction on Free Scavenging Activity of Sonneratia caseolaris
Degenerative diseases such as stroke and cancer arise due to oxidative stress by a large number of reactive oxygen species (ROS) in the body. Free radical scavenging (antioxidant) compounds are needed to neutralize the ROS. The natural antioxidant potential of mangrove species Sonneratia caseolaris...
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| Format: | Article |
| Language: | English |
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University of Brawijaya
2024-06-01
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| Series: | Journal of Experimental Life Science |
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| Online Access: | https://jels.ub.ac.id/index.php/jels/article/view/563 |
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| author | Feni Iranawati Yoan Oktavia Rarasrumdyah Kasitowati Hartati Kartikaningsih Ledhyane Ika Harlyan Sunanto Arifin |
| author_facet | Feni Iranawati Yoan Oktavia Rarasrumdyah Kasitowati Hartati Kartikaningsih Ledhyane Ika Harlyan Sunanto Arifin |
| author_sort | Feni Iranawati |
| collection | DOAJ |
| description | Degenerative diseases such as stroke and cancer arise due to oxidative stress by a large number of reactive oxygen species (ROS) in the body. Free radical scavenging (antioxidant) compounds are needed to neutralize the ROS. The natural antioxidant potential of mangrove species Sonneratia caseolaris has been widely explored. However, its extraction is usually carried out with polar solvents such as methanol. Besides being more toxic than ethanol, methanol can cause blindness and death when inhaled in large quantities. Additionally, Indonesia, as the country with the largest Muslim population, requires the use of halal products for food and cosmetics. This study aims to analyze the scavenging activities of S. caseolaris with methanol and distilled water as the polar solvents for extraction. Antioxidant activity was tested with the free radical assay method of DPPH (2,2-diphenyl-1-picrylhydrazyl radicals). The test results were calculated as the IC50 value, a concentration capable of reducing free radicals by 50%. The antioxidant activity test showed that the IC50 values of methanol and distilled water were 18.9 ppm and 36 ppm, respectively. Therefore, both are considered very strong antioxidants. It indicates that distilled water is an acceptable substitute for methanol in the extraction process. |
| format | Article |
| id | doaj-art-2c649cd2c4a8407fa0becb5b4d8d862e |
| institution | DOAJ |
| issn | 2087-2852 2338-1655 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | University of Brawijaya |
| record_format | Article |
| series | Journal of Experimental Life Science |
| spelling | doaj-art-2c649cd2c4a8407fa0becb5b4d8d862e2025-08-20T03:19:16ZengUniversity of BrawijayaJournal of Experimental Life Science2087-28522338-16552024-06-011428792https://doi.org/10.21776/ub.jels.2024.014.02.06An Assessment of Polar Solvent Extraction on Free Scavenging Activity of Sonneratia caseolarisFeni Iranawati0Yoan Oktavia1Rarasrumdyah Kasitowati2Hartati Kartikaningsih3Ledhyane Ika Harlyan4Sunanto Arifin5Universitas Brawijaya, Malang, IndonesiaUniversitas Brawijaya, Malang, IndonesiaUniversitas Brawijaya, Malang, IndonesiaUniversitas Brawijaya, Malang, IndonesiaUniversitas Brawijaya, Malang, IndonesiaYayasan Putra Indonesia, Malang, IndonesiaDegenerative diseases such as stroke and cancer arise due to oxidative stress by a large number of reactive oxygen species (ROS) in the body. Free radical scavenging (antioxidant) compounds are needed to neutralize the ROS. The natural antioxidant potential of mangrove species Sonneratia caseolaris has been widely explored. However, its extraction is usually carried out with polar solvents such as methanol. Besides being more toxic than ethanol, methanol can cause blindness and death when inhaled in large quantities. Additionally, Indonesia, as the country with the largest Muslim population, requires the use of halal products for food and cosmetics. This study aims to analyze the scavenging activities of S. caseolaris with methanol and distilled water as the polar solvents for extraction. Antioxidant activity was tested with the free radical assay method of DPPH (2,2-diphenyl-1-picrylhydrazyl radicals). The test results were calculated as the IC50 value, a concentration capable of reducing free radicals by 50%. The antioxidant activity test showed that the IC50 values of methanol and distilled water were 18.9 ppm and 36 ppm, respectively. Therefore, both are considered very strong antioxidants. It indicates that distilled water is an acceptable substitute for methanol in the extraction process.https://jels.ub.ac.id/index.php/jels/article/view/563antioxidantextractionmangrovesolventsonneratia. |
| spellingShingle | Feni Iranawati Yoan Oktavia Rarasrumdyah Kasitowati Hartati Kartikaningsih Ledhyane Ika Harlyan Sunanto Arifin An Assessment of Polar Solvent Extraction on Free Scavenging Activity of Sonneratia caseolaris Journal of Experimental Life Science antioxidant extraction mangrove solvent sonneratia. |
| title | An Assessment of Polar Solvent Extraction on Free Scavenging Activity of Sonneratia caseolaris |
| title_full | An Assessment of Polar Solvent Extraction on Free Scavenging Activity of Sonneratia caseolaris |
| title_fullStr | An Assessment of Polar Solvent Extraction on Free Scavenging Activity of Sonneratia caseolaris |
| title_full_unstemmed | An Assessment of Polar Solvent Extraction on Free Scavenging Activity of Sonneratia caseolaris |
| title_short | An Assessment of Polar Solvent Extraction on Free Scavenging Activity of Sonneratia caseolaris |
| title_sort | assessment of polar solvent extraction on free scavenging activity of sonneratia caseolaris |
| topic | antioxidant extraction mangrove solvent sonneratia. |
| url | https://jels.ub.ac.id/index.php/jels/article/view/563 |
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