Tracing the history of clinical practice of liquid biopsy: a bibliometric analysis
IntroductionLiquid biopsy holds great promise in clinical diagnosis, treatment, and prognostic monitoring. This study reveals the development of liquid biopsy in clinical practice through a comprehensive bibliometric analysis.MethodsA total of 40 years of research literature in this field was includ...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1574736/full |
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| author | Shuo Zhang Hongwei Zhao Kangchun Wang Lijie Li Qi Pan Qi Pan Meitong Lu Xing Zhang |
| author_facet | Shuo Zhang Hongwei Zhao Kangchun Wang Lijie Li Qi Pan Qi Pan Meitong Lu Xing Zhang |
| author_sort | Shuo Zhang |
| collection | DOAJ |
| description | IntroductionLiquid biopsy holds great promise in clinical diagnosis, treatment, and prognostic monitoring. This study reveals the development of liquid biopsy in clinical practice through a comprehensive bibliometric analysis.MethodsA total of 40 years of research literature in this field was included from the Web of Science Core Collection (WoSCC), analyzing the evolving research trends of liquid biopsy in clinical practice. We constructed co-occurrence networks for countries, institutions, authors, and keywords, integrating citation analysis and journal impact metrics to provide a comprehensive view of the research landscape in the field of liquid biopsy.ResultsThe results show a significant growth trend in the clinical practice of liquid biopsy, with China and the United States being the leading contributors. Institutions such as Harvard University and the University of California system play a central role in the global collaboration network. Cancers has become the primary publication outlet for the field, while highly cited journals like Clinical Cancer Research play a crucial role in advancing its development. Keyword analysis reveals that research has progressively expanded into clinical applications, personalized treatment, and prognostic evaluation.DiscussionOverall, as technology and applications continue to mature, liquid biopsy is expected to play an even greater role in the early diagnosis, treatment evaluation, and personalized treatment of cancer and other diseases. |
| format | Article |
| id | doaj-art-2c611646c0cb4d7797d3353de475a37b |
| institution | OA Journals |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-2c611646c0cb4d7797d3353de475a37b2025-08-20T01:50:22ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-05-011610.3389/fimmu.2025.15747361574736Tracing the history of clinical practice of liquid biopsy: a bibliometric analysisShuo Zhang0Hongwei Zhao1Kangchun Wang2Lijie Li3Qi Pan4Qi Pan5Meitong Lu6Xing Zhang7College of New Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, ChinaDepartment of Third Cardre’s Ward, General Hospital of Northern Theater Command, Shenyang, ChinaSchool of Medicine, Southeast University, Nanjing, ChinaDepartment of Ultrasound, Liaocheng People’s Hospital, Liaocheng, ChinaDepartment of Organ Transplantation and Hepatobiliary, The First Affiliated Hospital of China Medical University, Shenyang, ChinaThe Key Laboratory of Organ Transplantation in Liaoning Province, The First Affiliated Hospital of China Medical University, Shenyang, ChinaDepartment of Third Cardre’s Ward, General Hospital of Northern Theater Command, Shenyang, ChinaDepartment of Third Cardre’s Ward, General Hospital of Northern Theater Command, Shenyang, ChinaIntroductionLiquid biopsy holds great promise in clinical diagnosis, treatment, and prognostic monitoring. This study reveals the development of liquid biopsy in clinical practice through a comprehensive bibliometric analysis.MethodsA total of 40 years of research literature in this field was included from the Web of Science Core Collection (WoSCC), analyzing the evolving research trends of liquid biopsy in clinical practice. We constructed co-occurrence networks for countries, institutions, authors, and keywords, integrating citation analysis and journal impact metrics to provide a comprehensive view of the research landscape in the field of liquid biopsy.ResultsThe results show a significant growth trend in the clinical practice of liquid biopsy, with China and the United States being the leading contributors. Institutions such as Harvard University and the University of California system play a central role in the global collaboration network. Cancers has become the primary publication outlet for the field, while highly cited journals like Clinical Cancer Research play a crucial role in advancing its development. Keyword analysis reveals that research has progressively expanded into clinical applications, personalized treatment, and prognostic evaluation.DiscussionOverall, as technology and applications continue to mature, liquid biopsy is expected to play an even greater role in the early diagnosis, treatment evaluation, and personalized treatment of cancer and other diseases.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1574736/fullliquid biopsyclinical practicebiomarkersbibliometric analysiscancer |
| spellingShingle | Shuo Zhang Hongwei Zhao Kangchun Wang Lijie Li Qi Pan Qi Pan Meitong Lu Xing Zhang Tracing the history of clinical practice of liquid biopsy: a bibliometric analysis Frontiers in Immunology liquid biopsy clinical practice biomarkers bibliometric analysis cancer |
| title | Tracing the history of clinical practice of liquid biopsy: a bibliometric analysis |
| title_full | Tracing the history of clinical practice of liquid biopsy: a bibliometric analysis |
| title_fullStr | Tracing the history of clinical practice of liquid biopsy: a bibliometric analysis |
| title_full_unstemmed | Tracing the history of clinical practice of liquid biopsy: a bibliometric analysis |
| title_short | Tracing the history of clinical practice of liquid biopsy: a bibliometric analysis |
| title_sort | tracing the history of clinical practice of liquid biopsy a bibliometric analysis |
| topic | liquid biopsy clinical practice biomarkers bibliometric analysis cancer |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1574736/full |
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