Restless legs syndrome and multiple sclerosis: a Brazilian multicenter study and meta-analysis of the literature
OBJECTIVE: The increased prevalence of restless legs syndrome (RLS) in multiple sclerosis (MS) has recently been the subject of a few papers. The present study investigated the prevalence of RLS symptoms in MS patients and in controls in four Brazilian cities. Additionally, a systematic review and m...
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| Format: | Article |
| Language: | English |
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Thieme Revinter Publicações
2011-04-01
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| Series: | Arquivos de Neuro-Psiquiatria |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2011000200007&lng=en&tlng=en |
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| author | Yára Dadalti Fragoso Alessandro Finkelsztejn Sidney Gomes Damacio Ramon Kaimen Maciel Celso Luis S. Oliveira Josiane Lopes Rafael A. Cristovam |
| author_facet | Yára Dadalti Fragoso Alessandro Finkelsztejn Sidney Gomes Damacio Ramon Kaimen Maciel Celso Luis S. Oliveira Josiane Lopes Rafael A. Cristovam |
| author_sort | Yára Dadalti Fragoso |
| collection | DOAJ |
| description | OBJECTIVE: The increased prevalence of restless legs syndrome (RLS) in multiple sclerosis (MS) has recently been the subject of a few papers. The present study investigated the prevalence of RLS symptoms in MS patients and in controls in four Brazilian cities. Additionally, a systematic review and meta-analysis of the literature was carried out on the subject of RLS-MS. METHOD: MS patients and controls were investigated regarding the presence of the four typical symptoms of RLS. A questionnaire assessing RLS severity was also used for patients and controls presenting the four RLS symptoms criteria. The systematic review and meta-analysis on the subject were carried out according to the strict international criteria. RESULTS: In the present report, the RLS-MS association was confirmed as being more than fortuitous in Brazilian MS patients, in a multicenter case-control study. MS patients also presented RLS symptoms of greater severity than did the control population. A systematic review and meta-analysis of the literature showed that MS patients had a fourfold higher chance of presenting RLS than did the controls. CONCLUSION: Although underlying mechanisms to explain the association RLS-MS are still a matter of discussion, there is a clear association of these two neurological conditions. |
| format | Article |
| id | doaj-art-2c56d7e331894fbe8ac1f01bfc666b9d |
| institution | OA Journals |
| issn | 1678-4227 |
| language | English |
| publishDate | 2011-04-01 |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-2c56d7e331894fbe8ac1f01bfc666b9d2025-08-20T02:38:49ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria1678-42272011-04-01692a18018310.1590/S0004-282X2011000200007S0004-282X2011000200007Restless legs syndrome and multiple sclerosis: a Brazilian multicenter study and meta-analysis of the literatureYára Dadalti Fragoso0Alessandro Finkelsztejn1Sidney Gomes2Damacio Ramon Kaimen Maciel3Celso Luis S. Oliveira4Josiane Lopes5Rafael A. Cristovam6UNIMESUniversidade Federal do Rio Grande do SulHospital Beneficência Portuguesa de São PauloUniversidade Estadual de LondrinaUNIMESUniversidade Estadual de LondrinaUniversidade Federal do Rio Grande do SulOBJECTIVE: The increased prevalence of restless legs syndrome (RLS) in multiple sclerosis (MS) has recently been the subject of a few papers. The present study investigated the prevalence of RLS symptoms in MS patients and in controls in four Brazilian cities. Additionally, a systematic review and meta-analysis of the literature was carried out on the subject of RLS-MS. METHOD: MS patients and controls were investigated regarding the presence of the four typical symptoms of RLS. A questionnaire assessing RLS severity was also used for patients and controls presenting the four RLS symptoms criteria. The systematic review and meta-analysis on the subject were carried out according to the strict international criteria. RESULTS: In the present report, the RLS-MS association was confirmed as being more than fortuitous in Brazilian MS patients, in a multicenter case-control study. MS patients also presented RLS symptoms of greater severity than did the control population. A systematic review and meta-analysis of the literature showed that MS patients had a fourfold higher chance of presenting RLS than did the controls. CONCLUSION: Although underlying mechanisms to explain the association RLS-MS are still a matter of discussion, there is a clear association of these two neurological conditions.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2011000200007&lng=en&tlng=enesclerose múltiplasíndrome das pernas inquietasmetanálise |
| spellingShingle | Yára Dadalti Fragoso Alessandro Finkelsztejn Sidney Gomes Damacio Ramon Kaimen Maciel Celso Luis S. Oliveira Josiane Lopes Rafael A. Cristovam Restless legs syndrome and multiple sclerosis: a Brazilian multicenter study and meta-analysis of the literature Arquivos de Neuro-Psiquiatria esclerose múltipla síndrome das pernas inquietas metanálise |
| title | Restless legs syndrome and multiple sclerosis: a Brazilian multicenter study and meta-analysis of the literature |
| title_full | Restless legs syndrome and multiple sclerosis: a Brazilian multicenter study and meta-analysis of the literature |
| title_fullStr | Restless legs syndrome and multiple sclerosis: a Brazilian multicenter study and meta-analysis of the literature |
| title_full_unstemmed | Restless legs syndrome and multiple sclerosis: a Brazilian multicenter study and meta-analysis of the literature |
| title_short | Restless legs syndrome and multiple sclerosis: a Brazilian multicenter study and meta-analysis of the literature |
| title_sort | restless legs syndrome and multiple sclerosis a brazilian multicenter study and meta analysis of the literature |
| topic | esclerose múltipla síndrome das pernas inquietas metanálise |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2011000200007&lng=en&tlng=en |
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